Antiproliferative Activity of the Main Constituents from Phyllanthus emblica

Zhang, Yingjun; Nagao, Tsuneatsu; Tanaka, Takashi; Yang, Chong‐Ren; Okabe, Hikaru; Kouno, Isao

doi:10.1248/bpb.27.251

Cited by 122 publications

(76 citation statements)

References 19 publications

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“…1a) was isolated from the branches and leaves of Phyllanthus emblica Linn, and purified as described previously [42]. The purity levels achieved were over 98%.…”

Section: Compoundmentioning

confidence: 99%

Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus

et al. 2011

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Influenza A virus (IAV) infection is a major public health threat leading to significant morbidity and mortality. The emergence of drug-resistant virus strains highlights urgent needs to develop novel antiviral drugs with alternative modes of action. Pentagalloyl glucose (PGG), a natural occuring polyphenolic compound, possesses broad spectrum of biological activities. In this study, we found PGG has anti-influenza virus activity and investigated its possible mechanism(s) of action in vitro.

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“…1a) was isolated from the branches and leaves of Phyllanthus emblica Linn, and purified as described previously [42]. The purity levels achieved were over 98%.…”

Section: Compoundmentioning

confidence: 99%

Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus

et al. 2011

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“…EO or its medicinal preparations may prove to be beneficial as a component of combination therapy in cancer patients under cyclophosphamide treatment. [33] Phenolic compounds and the major components from the fruit juice of EO and from the branches, leaves and roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth.…”

Section: Geographical Distributionmentioning

confidence: 95%

A Review on Phytochemical, Pharmacological and Potential Therapeutic Uses of Phyllanthus Emblica

Mandal¹

2017

WJPR

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Amla has a hallowed position in Ayurveda-an Indian indigenous system of medicine. According to belief in Indian mythology, Amla is the first tree to be created in the universe; which belongs to the family of Euphorbiaceae and is also known as Phyllanthus emblica or Indian gooseberry. Amla is native to India and also grows in tropical and subtropical regions of Pakistan, Uzbekistan, Sri Lanka, South East Asia, China and Malaysia.[1] The fruits of Amla are widely used in the Ayurvedic preparation and are believed to increase defence against diseases. It has a beneficial role in degenerative diseases like cancer, diabetes, liver treatment, ulcer, anaemia, heart trouble1 and also is an important constituent in hepatoprotective formulas available.[2]

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“…The rest of the compounds were androsterone which plays a vital role in the endocrine system of the body [19,20]. [21][22][23]. This is the first report of Phyllanthus emblica cytotoxicity against HL60 cancer cells.…”

Section: Gc-ei/ms Profilingmentioning

confidence: 99%

Ethnopharmacological Evaluation of Medicinal Plants for Cytotoxicity Against Various Cancer Cell Lines

Thakur

Ahirwar

2017

Int J Pharm Pharm Sci

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Objective: To evaluate the cytotoxic potential of leaves and seeds of Hibiscus sabdariffa L., fruit juice of Phyllanthus emblica, rhizomes of Dryopteris cochleata and flowers of Caesalpinia decapetala (Roth) Alston along with the chemical profiling of the most toxic extract through Gas-mass spectroscopy-MS technique. Methods:The hydroalcoholic extract of the selected crude drugs was prepared by maceration method and the extracts were undergone through phytochemical analysis. The cytotoxic activity of the hydroalcoholic extract was performed against four cancer cell lines i.e. liver (HepG2), breast (MCF7), prostate (PC-3) and leukemia (HL60) using sulphorhodamine B assay. The hydroalcoholic extract of Caesalpinia decapetala flowers was profiled through using gas mass spectroscopy. Results:The results confirmed that Phyllanthus emblica inhibited HL60 cancer cells at the dose of 35.6 µg/ml and show dose-dependent growth inhibition. The flowers of Caesalpinia decapetala inhibited nearly fifty percent of HL60 cancer cells at very low dose i. e 10 µg/ml. The analysis of Caesalpinia decapetala flowers shows the presence of diterpenoid furanolactones, bufadienolides, polycyclic enones, and androsterone. Conclusion:The fruit juice of Phyllanthus emblica and flowers of Caesalpinia decapetala showed good inhibitory activity against HL60 cancer cell line. The use of Phyllanthus emblica in herbal medicine is justified. The data obtained impelled to further assess the in vivo efficacy of Caesalpinia decapetala flowers for anticancer activity.

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Antiproliferative Activity of the Main Constituents from Phyllanthus emblica

Cited by 122 publications

References 19 publications

Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus

Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus

A Review on Phytochemical, Pharmacological and Potential Therapeutic Uses of Phyllanthus Emblica

Ethnopharmacological Evaluation of Medicinal Plants for Cytotoxicity Against Various Cancer Cell Lines

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