Antiproliferative activity of tea catechins associated with casein micelles, using HT29 colon cancer cells

Haratifar, Sanaz; Meckling, Kelly A.; Corredig, Milena

doi:10.3168/jds.2013-7263

Cited by 78 publications

(42 citation statements)

References 50 publications

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“…These are also expressed in several cancer cell types, and EGCG is known to modulate the function of OATPs killing in OATP1B3-expressing cells (Zhang et al 2013). Site-specific delivery of EGCG has been studied using casein nanoencapsulated micelles in colon cancer cells (Haratifar et al 2014).…”

Section: Mechanism Of Action Of Egcgmentioning

confidence: 99%

Green tea polyphenols and their potential role in health and disease

2015

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There is a growing body of evidence that plant polyphenols such as resveratrol, anthocyanins, catechins, and terpenes like taxol are effectively used in the treatment of chronic conditions including cancer, Alzheimer, Parkinsonism, diabetes, aging, etc. The link between oxidative stress and inflammation is well accepted. Thus, the mechanism of action of these natural products is partly believed to be through their significant antioxidant properties. The main constituent of green tea, with clinical significance, is epigallocatechin gallate (EGCG). It has been associated with antitumor, anti-Alzheimer, and anti-aging properties, improve redox status at the tissue level possibly preventing system level structural damage. This review focuses on EGCG and its potential therapeutic role in health and disease.

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Section: Mechanism Of Action Of Egcgmentioning

confidence: 99%

Green tea polyphenols and their potential role in health and disease

2015

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“…Finally, some key literature data involve the use of micelles based on synthetic PEG-PLA (Sun et al, 2014a) or naturally occurring casein (Haratifar et al, 2014a,b) for the efficient EGCG delivery in pancreas (Sun et al, 2014a) and colon cancers in vitro (Haratifar et al, 2014a) and in vivo (Haratifar et al, 2014b).…”

Section: Polymeric Vesicular Systemsmentioning

confidence: 99%

Polyphenols delivery by polymeric materials: challenges in cancer treatment

et al. 2017

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Nanotechnology can offer different solutions for enhancing the therapeutic efficiency of polyphenols, a class of natural products widely explored for a potential applicability for the treatment of different diseases including cancer. While possessing interesting anticancer properties, polyphenols suffer from low stability and unfavorable pharmacokinetics, and thus suitable carriers are required when planning a therapeutic protocol. In the present review, an overview of the different strategies based on polymeric materials is presented, with the aim to highlight the strengths and the weaknesses of each approach and offer a platform of ideas for researchers working in the field.

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“…Moreover, the growing epidemiologic evidence has demonstrated that flavonoid consumption is associated with a decreased risk of colorectal cancer, which has recently been documented by a large casecontrol study [7]. Hitherto, a number of flavonoids, exemplified by isoquercitrin [8], quercetin [9], and catechin [10] have been shown to exert anti-colorectal cancer activity by inhibiting cell proliferation.…”

Section: Introductionmentioning

confidence: 99%