Antiproliferative activity of novel benzo[b][1,6]naphthyridines in human solid tumor cell lines

Greener organic synthetic methods: Sonochemistry and heterogeneous catalysis promoted multicomponent reactions

“…The 1,6-naphthyridine is a framework of great interest in medical chemistry, as present several biological properties, such as antitumor [179] , [180] and antiviral [181] . Solid acid carbonaceous materials (C-SO 3 H) have emerged as heterogeneous catalysts of interest in greener organic synthesis, due to the fact that they combine acid catalytic properties with the possibility of more efficient recycling.…”

Synthesis of Substituted Pyrano[3,4‐b]Quinolines by Silver‐Catalyzed Regioselective Intramolecular Cyclization of 3‐Alkynylquinoline Aldehydes

“…described versatile access to pyranoquinoline, furoquinoline core moieties and elaborated the cyclization mode switched from 6‐ endo ‐ dig to 5‐ exo ‐ dig with different silver additives (Scheme 1b) [23] . Subsequently Cikotiene group published silver catalyzed regioselective synthetic method for construction of pyranoquinoline derivatives, in thermal method and also microwave irradiation (Scheme 1c) [24] and they also studied the antimicrobial activity in bacterial and fungal strains [24a] . Whereas scope of alcohols were limited.…”

Cubic Perovskite ZnTiO3 Nanopowder as a Recyclable Heterogeneous Catalyst for the Synthesis of 1,6‐Naphthyridines in Water

“…Functionalized 1,6‐naphthyridines are an important class of organic molecules that have attracted much attention from those in the synthetic and medicinal fields 3. Naphthyridine derivatives are extensively used in various pharmacological functions for their antiproliferative, anticancer, HIV‐1 integrase inhibitor, antithrombotic, FGF Receptor‐1 tyrosin kinase inhibitor, allosteric inhibitor of Akt1 and Akt2, antimalerial, and antifungal properties; they also act as selective antagonists of 5‐HT4 receptors 4–7. Over the years, numerous synthetic methods8, 9 have been developed for the construction of these valuable privileged structures.…”