Antiproliferative activity of lichen extracts on murine myeloma cells

Triggiani, Doriana; Ceccarelli, D.; Tiezzi, Antonio; Pisani, Tommaso; Munzi, Silvana; Gaggi, Carlo

doi:10.2478/s11756-009-0005-y

Cited by 29 publications

(17 citation statements)

References 23 publications

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“…Manojlović, et al [11] explored the anticancer properties of Thamnolia vermicularis . Trigiani et al [26] found strong anticancer activity for Xanthoria parietina. …”

Section: Resultsmentioning

confidence: 99%

Biological Activities of Toninia candida and Usnea barbata Together with Their Norstictic Acid and Usnic Acid Constituents

Ranković

Kosanić

Stanojković

et al. 2012

IJMS

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The aim of this study was to investigate the chemical composition of acetone extracts of the lichens Toninia candida and Usnea barbata and in vitro antioxidant, antimicrobial, and anticancer activities of these extracts together with some of their major metabolites. The chemical composition of T. candida and U. barbata extracts was determined using HPLC-UV analysis. The major phenolic compounds in these extracts were norstictic acid (T. candida) and usnic acid (U. barbata). Antioxidant activity was evaluated by free radical scavenging, superoxide anion radical scavenging, reducing power and determination of total phenolic compounds. Results of the study proved that norstictic acid had the largest antioxidant activity. The total content of phenols in the extracts was determined as the pyrocatechol equivalent. The antimicrobial activity was estimated by determination of the minimal inhibitory concentration using the broth microdilution method. The most active was usnic acid with minimum inhibitory concentration values ranging from 0.0008 to 0.5 mg/mL. Anticancer activity was tested against FemX (human melanoma) and LS174 (human colon carcinoma) cell lines using the microculture tetrazolium test. Usnic acid was found to have the strongest anticancer activity towards both cell lines with IC50 values of 12.72 and 15.66 μg/mL.

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“…Manojlović, et al [11] explored the anticancer properties of Thamnolia vermicularis . Trigiani et al [26] found strong anticancer activity for Xanthoria parietina. …”

Section: Resultsmentioning

confidence: 99%

Biological Activities of Toninia candida and Usnea barbata Together with Their Norstictic Acid and Usnic Acid Constituents

Ranković

Kosanić

Stanojković

et al. 2012

IJMS

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“…Only a few studies have found anticancer activity of other lichens. Manojlović et al 42 explored the anticancer properties of Thamnolia vermicularis , while Triggiani et al 43 found strong anticancer activity of Xanthoria parietina .…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, antimicrobial and anticancer activities of three Parmelia species

Kosanić¹,

Ranković²,

Stanojković³

2012

J Sci Food Agric

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“…Manojlović et al (2010b) explored anticancer properties of Thamnolia vermicularis. Triggiani et al (2009) found strong anticancer activity for Xanthoria parietina. Compared with them, the results of this research suggest that the methanol extract of C. islandica exhibited a relatively powerful anticancer activity.…”

Section: Resultsmentioning

confidence: 98%

Evaluation of in vitro antioxidant, antimicrobial, genotoxic and anticancer activities of lichen Cetraria islandica

et al. 2014

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In this study, the antioxidant, antimicrobial, genotoxic and anticancer activities of Cetraria islandica methanol extract were determined by using free radical and superoxide anion scavenging activity, reducing power, determination of total phenolic compounds and flavonoid contents, broth microdilution minimal inhibitory concentration against five bacterial and five fungal species, cytokinesis block micronucleus (MN) assay on peripheral blood lymphocytes (PBLs) and the microculture tetrazolium test on FemX (human melanoma) and LS174 (human colon carcinoma) cell lines. As a result of the study, we found that C. islandica methanol extract exhibited moderate free-radical-scavenging activity with IC 50 values 678.38 lg/ml. Moreover, the tested extract had effective reducing power and superoxide anion radical scavenging. The minimal inhibitory concentration values against the tested microorganisms ranged from 0.312 to 5 mg/ml. The extract increased MN frequency in a dose dependent manner, but it was significant in higher tested concentrations (50, 100 and 200 lg/ml). No significant differences were observed between NDI values in all treatments and untreated PBLs. In addition, the tested extract had strong anticancer activity towards both cell lines with IC 50 values of 22.68 and 33.74 lg/ml. It can be concluded that the tested extract exhibited a certain level of in vitro antioxidant, antimicrobial, genotoxic and anticancer activities.

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Antiproliferative activity of lichen extracts on murine myeloma cells

Cited by 29 publications

References 23 publications

Biological Activities of Toninia candida and Usnea barbata Together with Their Norstictic Acid and Usnic Acid Constituents

Biological Activities of Toninia candida and Usnea barbata Together with Their Norstictic Acid and Usnic Acid Constituents

Antioxidant, antimicrobial and anticancer activities of three Parmelia species

Evaluation of in vitro antioxidant, antimicrobial, genotoxic and anticancer activities of lichen Cetraria islandica

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