Antioxidant, antimicrobial and anticancer activities of three <i>Parmelia</i> species

Kosanić, Marijana; Ranković, Branislav; Stanojković, Tatjana

doi:10.1002/jsfa.5559

Cited by 65 publications

(43 citation statements)

References 82 publications

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“…Reason for greater sensitivity of bacteria than fungi is differences in the composition and permeability of the cell wall. The cell wall of Gram-positive bacteria is made of peptidoglucanes and teichoic acids, the cell wall of Gram-negative bacteria is made of peptidoglucanes, lipopolysacharides and lipoproteins, while the cell wall of fungi is poorly permeable and it consists of polysaccharides such as hitchin and glucan (Kosanić et al 2012). In terms on antimicrobial activity we found we found interesting result that P. mirabilis (Gram-negative bacteria) was sensitive than S. aureus (Gram-positive bacteria).…”

Section: Discussionmentioning

confidence: 86%

“…The antioxidant activities of the individual phenolic compounds may depend on structural factors, such as the number of phenolic hydroxyl or methoxyl groups and free carboxylic groups and other structural features (Jayabalan et al 2008). Researches proved antioxidant activity of some lichen species such as Bryoria fuscescens, Cetraria islandica, Lecanora muralis, Dermatocarpon intestiniformis, Parmelia saxatilis, Parmeliopsis ambigua, Peltigera rufescens, Platismatia glauca, Ramalina pollinaria, R. polymorph, Umbilicaria nylanderiana,Umbilicaria crustulosa, Usnea ghattenis, and U. longissima (Behera et al 2009;Kosanić et al 2012). Lopes et al (2008) indicated on free radical scavenging activity of lecanoric acid and its derivatives.…”

Section: Discussionmentioning

confidence: 99%

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Phytochemical study and antioxidant, antimicrobial and anticancer activities of Melanelia subaurifera and Melanelia fuliginosa lichens

et al. 2016

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The aim of this study was to investigate antioxidant, antimicrobial and anticancerous activity of Melanelia subaurifera and Melanelia fuliginosa. The phytochemical analysis was determined by HPLC-UV method. Antioxidant activity was evaluated by DPPH and reducing power assay while antimicrobial activity was determined by minimal inhibitory concentration. The cytotoxic activity was tested using MTT method. The method for quantification of 2'-O-methyl anziaic acid and lecanoric acid in these lichens using RF-HPLC was also developed and validated. The depsides (lecanoric acid, gyrophoric acid, atranorin, anziaic acid and 2'-O-methyl anziaic acid), and dibenzofurane (usnic acid) were identified in these lichens. The antioxidant activity (IC50) of lichens extracts ranged from 121.52 to 424.51 μg/ml. 2'-O-Methyl anziaic acid showed the highest antimicrobial activity with MIC ranging from 0.0625 to 1 mg/ml. M. subaurifera extract showed the highest cytotoxic activity against the tested cell lines (IC50 = 9.88 to 31.64 μg/ml).

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Phytochemical study and antioxidant, antimicrobial and anticancer activities of Melanelia subaurifera and Melanelia fuliginosa lichens

et al. 2016

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“…For a long time, some lichen species have been used in traditional medicine in the treatment of numerous infectious diseases 2 International Journal of Antibiotics [9]. Lichen substances exert a wide range of biological activities such as antibiotic, antimycotic, antiviral, antiinflammatory, analgesic, antipyretic, antiproliferative, and cytotoxic effects [10][11][12]. Due to a relatively recent resurgence in lichen bioactivity, the therapeutic potential of many classes of lichen metabolites in medicine has largely remained unexplored.…”

Section: Introductionmentioning

confidence: 99%

Protolichesterinic Acid: A Prominent Broad Spectrum Antimicrobial Compound from the Lichen Usnea albopunctata

Sasidharan

Sreekala

Lakshmanan

et al. 2014

International Journal of Antibiotics

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The aim of this study is to investigate the antimicrobial compounds present in the lichen Usnea albopunctata. Ethyl acetate extract was purified by silica gel column chromatography to obtain a major compound and the chemical structure was characterized by 1 H-NMR, 13 C-NMR, DEPT, 1 H-1 H COSY, HMQC, HMBC, UV, and HR-MS spectroscopic methods as protolichesterinic acid. The antimicrobial activity was estimated by determination of the minimal inhibitory concentration by the broth microdilution method and agar disc diffusion method against thirteen human pathogenic bacterial and four fungal strains. Protolichesterinic acid recorded significant broad spectrum antimicrobial property. The best antibacterial activity was recorded against K. pneumonia (0.25 g/mL) and V. cholerae (0.5 g/mL). Significant antifungal activity was recorded against T. rubrum (0.12 g/mL), which is significantly better than the standard antifungal agent. Protolichesterinic acid is reported for the first time from Usnea albopunctata. Antifungal activity of protolichesterinic acid against medically important fungi is also reported for the first time. Thus the results of the present study suggest that protolichesterinic acid has significant antimicrobial activities and has the strong potential to be developed as an antimicrobial drug after further clinical evaluation.

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“…It has bitter or saline taste [14]. Parmelia is useful in treating a number of ailments [15,16] and has also been reported to possess antimicrobial [17,18], antiviral [19], antioxidant [20], antipyretic [21], anticancer [22] and antispasmodic [23] activities. In this study, Parmelia perlata was examined for its antioxidant, anticholesterol and anticancer activities to derive bioactive compounds from natural origin as great promise for biochemical applications and better human health.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Studies on Antioxidant, Hypolipidemic and Cytotoxic Potential of Parmelia Perlata

Rahman¹,

Vijaya²,

Ghosh³

et al. 2014

AJLS

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New drug preparations of natural origin are in need due to the numerous side effects and resistance development through the continuous and uncontrolled use of synthetic drugs. Lichens are reported to have manifold biological activities and in this study, antioxidant, hypolipidemic and cytotoxic potential of Parmelia perlata were assessed. Methanolic extract of P. perlata was prepared and used in DPPH assay, total phenolic content and total antioxidant potential assays. In vitro anti-cholesterol and cytotoxic assay using HCT 116 cell lines were performed. The results revealed that P. perlata contain high phenolic contents and antioxidant potential. Simvastatin was used as standard drug and the extracts demonstrated 48% anti-cholesterol activity. MTT assay using colon cancer cell lines (HCT 116) produced dose dependent cytotoxic effect with an IC50 value of 202.1 µg ml -1 .

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Antioxidant, antimicrobial and anticancer activities of three Parmelia species

Abstract: The present study showed that the tested lichen extracts exhibited strong antioxidant, antimicrobial and anticancer effects. This suggests that lichens may be used as possible natural antioxidant, antimicrobial and anticancer agents.

Cited by 65 publications

References 82 publications

Phytochemical study and antioxidant, antimicrobial and anticancer activities of Melanelia subaurifera and Melanelia fuliginosa lichens

Phytochemical study and antioxidant, antimicrobial and anticancer activities of Melanelia subaurifera and Melanelia fuliginosa lichens

Protolichesterinic Acid: A Prominent Broad Spectrum Antimicrobial Compound from the Lichen Usnea albopunctata

In Vitro Studies on Antioxidant, Hypolipidemic and Cytotoxic Potential of Parmelia Perlata

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