Antiproliferative Activity of Diarylheptanoids from the Seeds of Alpinia blepharocalyx

Ali, Mohammad; Banskota, Arjun H.; Tezuka, Yasuhiro; Saiki, Ikuo; Kadota, Shigetoshi

doi:10.1248/bpb.24.525

Cited by 60 publications

(34 citation statements)

References 22 publications

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“…Myricanone, a cyclic diarylheptanoid, showed anti-cancer effects on cancer cell lines HeLa and PC3 (Paul et al, 2013). Epicalyxin F and calyxin I isolated from ethanol extracts of A. blepharocalyx seeds exhibited potent anti-proliferative activity against human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells (Gewali et al, 1999;Ali et al, 2001). Blepharocalyxins D, E isolated from the ethanol extract of A. blepharocalyx seeds exhibited significant anti-proliferative activity against murine colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cells, with ED 50 values of 3.61 and 9.02 μM, respectively (Tezuka et al, 2000).…”

Section: Cytotoxicity and Anti-carcinogenic Activitymentioning

confidence: 99%

Diarylheptanoids as nutraceutical: A review

Ganapathy

Preethi

Moses

et al. 2019

Biocatalysis and Agricultural Biotechnology

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Phenolic compounds are naturally occurring compounds present ubiquitously in plants. They have potential health benefits and substantiate evidence for their nutraceutical applications. Diarylheptanoids are part of the broad class of plant phenolics with structurally divergent compounds. They have been used in traditional medicines and homemade remedies to treat various ailments, as organoleptic additives in foods, and also for aesthetic purposes. With their potential therapeutic and organoleptic characteristics, diarylhepatanoids can be rightly termed as nutraceuticals. This review summarizes the wide range of pharmacological activities of diarylhepatanoids and nutraceutical formulations, with relevance to human health.

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Section: Cytotoxicity and Anti-carcinogenic Activitymentioning

confidence: 99%

Diarylheptanoids as nutraceutical: A review

Ganapathy

Preethi

Moses

et al. 2019

Biocatalysis and Agricultural Biotechnology

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“…However, mechanism of the activity is still not clear. 12 It is proposed to be associated with the antioxidant property of the calyxins. 12 The present report provides a clue to the antiproliferative acivity of calyxin H by inhibition of the enzyme LSD1 associated with metastasis.…”

Section: Prediction Of Drug-likeness Of Derivatives Of the Lead Moleculementioning

confidence: 99%

Lysine specific demethylase 1 as therapeutic target of cancer

Panda

Bhoi

Rawal

et al. 2017

PBE

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Objective: Lysin specific demethylase 1 (LSD1) inhibits the tumor suppressor activity of p53 and facilitates the progress of tumor. In order to check the tumor growth, the activity of LSD1 enzyme is to be blunted. Methods:Phytochemicals from naturally occurring plant-based anticancer compound-activity-target (NPACT) database are screened with LSD1 as target applying genetic algorithm (GA) method to study best ligand poses and free energy of binding using Argus Lab. The prediction of drug-likeness and oral toxicity of the ligands are performed by the online tools Molsoft and ProTox respectively. Results:Calyxin H shows optimum binding affinity to both the substrate and FAD binding sites of LSD1. The LD 50 value (median lethal dose) of calyxin H is more than 1000 mg/kg body weight and the toxicity class is 4. Conclusions:Calyxin H is the inhibitor of choice against target LSD1. The lead molecule may be the future potential herbal drug for cancer treatment.

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“…In Japan, this rhizome is a traditional medicine for the prevention of liver illness. A dihydro derivative of bis-demethoxycurcumin was found, along with various diarylheptanoids, from the seeds, not rhizomes, of the Zingiberaceae plant Alpinia blepharocalyx [33]. The main pigment, curcumin, is also recognized as the main biologically active constituent of C. longa.…”

Section: Introductionmentioning

confidence: 99%

Curcumin: From Chemistry to Chemistry-Based Functions

Jitoe-Masuda¹,

Fujimoto²,

Masuda³

2013

Current Pharmaceutical Design

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Curcumin is a yellow pigment found in the spice turmeric and a main functional constituent of the rhizomes of Curcuma longa. The multi-functionality of curcumin has recently attracted much attention in various fields, including food, medicinal, and clinical industries. Three major curcuminoids, curcumin, demethoxycurcumin, and bis-demethoxycurcumin, are distributed in not only Curcuma, but also the Zingiber species; however, distribution of other curcuminoids is very limited in nature. The radical scavenging ability of curcumin, which is the basis of medicinal functionality, is its most important property. Herein, the structures of several rare curcuminoids that have been identified during the past four decades are summarized. Mechanistic studies of the radical trapping stage of curcumin are also comprehensively reviewed, and the studies on antioxidant effects derived from this radical trapping ability of curcuminoids are discussed. Various chemical reactions of curcumin, such as photo-oxidation, enzymatic oxidation, etc. are also summarized. In particular, antioxidation of curcumin in lipid media is introduced as a reaction unique to curcumin.

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Antiproliferative Activity of Diarylheptanoids from the Seeds of Alpinia blepharocalyx

Cited by 60 publications

References 22 publications

Diarylheptanoids as nutraceutical: A review

Diarylheptanoids as nutraceutical: A review

Lysine specific demethylase 1 as therapeutic target of cancer

Curcumin: From Chemistry to Chemistry-Based Functions

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