Antiproliferative activity of chelating N,O- and N,N-ruthenium(ii) arene functionalised poly(propyleneimine) dendrimer scaffolds

Abstract

Chelating neutral (N,O) and cationic (N,N) first- and second-generation ruthenium(II) arene metallodendrimers based on poly(propyleneimine) dendrimer scaffolds were obtained from dinuclear arene ruthenium precursors by reactions with salicylaldimine and iminopyridyl dendritic ligands, respectively. The N,N cationic complexes were isolated as hexafluorophosphate salts and were characterised by NMR and IR spectroscopy, and MALDI-TOF mass spectrometry. Related mononuclear complexes were obtained in a similar manner and their molecular structures have been determined by X-ray diffraction analysis. The cytotoxicities of the mono- and multinuclear complexes were established using A2780 and A2780cisR human ovarian carcinoma cancer cell lines.

Novel Mononuclear Ruthenium(II) Compounds in Cancer Therapy

“…transferrin and albumin) is believed to contribute to the general low toxicity and excellent cytotoxicity of ruthenium complexes (Ang and Dyson, 2006). Many of biological properties have been attributed to ruthenium complexes, for example: antitumor activity (Dyson, 2007;Bruijnincx and Sadler, 2009;Süss-Fink, 2010;Sreekanth et al, 2010;Govender et al, 2011), antioxidant activity (Paula et al, 2005), antinociceptive (Cristiano et al, 2008), antitubercular activity (Hadda et al, 2009) and immunomodulatory activity (Newcomb et al, 2003). In a recent article, we have proven that the above test compounds were shown significant antioxidant potentiality (Shyam et al, 2012).…”

Multi-Target Inhibition of Cancer Cell Growth by SiRNA Cocktails and 5-Fluorouracil Using Effective Piperidine-Terminated Phosphorus Dendrimers

“…Such a dendrimer of generation 3 probably has a more flexible structure with better accessibility of internal groups to cellular content. It should be noted that non-generation dependent cytotoxicity occurred with some other dendrimeric structures [38,39].…”

Half-Sandwich Ru(II) Halogenido, Valproato and 4-Phenylbutyrato Complexes Containing 2,2′-Dipyridylamine: Synthesis, Characterization, Solution Chemistry and In Vitro Cytotoxicity

“…Complex 1, recently reported as cytotoxic against the MCF-7 cells (IC 50 = 40.8 µM) [11], did not show any cytotoxicity in this work, up to the highest tested concentration (IC 50 > 100 µM) on the A2780 cells. Similarly, the different sensitivity of various types of cancer cells was reported for the Ru(II) half-sandwich complex [Ru(η 6 -p-cym)(L 6 )Cl]PF 6 containing 2-pyridylpropylimine (L 6 ), which was inactive against the A2780 cells (IC 50 > 200 µM) [33], but showed moderate activity at the MG63 human osteosarcoma cells (IC 50 = 88.5 µM) [34]. The replacement of the chlorido ligand of the inactive complex 1 by the bromido (for 2) or iodido (for 3) ones did not provide potent Ru(II) complexes.…”