Antiproliferative activities of several plant extracts from Turkey on rat brain tumor and human cervix carcinoma cell lines

Abstract

Turkey has a wide range of flora and fauna due to its climatic diversity. Medicinal plants from Turkey have been used since ancient times for their primary health care. In this study, we examined antiproliferative activities of the extracts from Crataegus monogyna, Vitis vinifera, Glycrrhiza glabra, Alnus glutinosa L. gaertn, and Alcea rosea against rat brain tumor (C6) and human cervical cancer (HeLa) cell lines. The results were compared with the standard anticancer drugs 5-Flurouracil (5-FU) and Cisplatin. C. monogyna, V. vinifera and A. rosea exhibited better antiproliferative activity than 5-FU and cisplatin at 100-75 μg/mL concentrations, against C6 cell lines. On the other hand, C. monogyna and V. vinifera extracts showed considerable antiproliferative activity against HeLa cells compared with 5-FU and cisplatin at 100-75 μg/mL. It can be suggested that, C. monogyna, A. glutinosa L. gaertn, V. vinifera and A. rosea extracts could be developed as an anticancer drug.

In vitro Biological Activities of Different Extracts from Alcea dissecta

“…It was also found that these extracts did not show antimicrobial activity against Pseudomonas aeruginosa CMUL 241, Escherichia coli CMUL 577, Staphylococcus aureus CMUL 491, Candida albicans ATCC 10231 strains (32). In another study, it was found that methanol extract from Alcea rosea aerial parts showed strong and selective cytotoxic activity on HeLA (IC 50 : 14.48 µg/mL) cells and C6 cell lines (37.63 µg/mL) (33). As a result of the in vivo experiment of water extract from flowers of Alcea aucheri, this extract has been disclosed to have strong anxiolytic and sedative properties (34).…”

Anti-proliferative, genotoxic and cytotoxic effects of phytochemicals isolated from Anatolian medicinal plants

“…Besides the anticancer properties of natural extracts, recent studies showed that, natural extracts can be more effective therapeutic agents against tumors than standard chemotherapeutic candidates (118). It was demonstrated that the methanol extract of Crataegus monogyna (Rosaceae) exhibited better antiproliferative activity than standard chemotherapeutics 5-flurouracil and cisplatin on brain tumors and cervical cancer cells (119). Furthermore, the natural extracts can be added to the standard anticancer drugs for increasing their treatment effectiveness and reducing their side effects.…”

iCELLigence real-time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines

“…This suggests that flavone compounds have a potential application in the prevention and treatment of cancer. Studies have investigated the cytotoxicity and antiproliferative activities of extracts obtained from various herbs ( 26 , 27 ). The in vitro cytotoxic effects of numerous herbal extracts have been investigated on MDA-MB-231 and MCF-7 breast cancer cells ( 28 ).…”