Antiproliferation effects of ethanol extract of garlic peels on human cancer cell lines

Abstract

Ethanol extract of garlic peels (GPE) was investigated for its antiproliferative effects on human cancer cell lines. Human lung cancer cell line A549 treated with 500 μg/mL GPE resulted in the growth inhibition of A549 by 90%. In stomach cancer cell AGS proliferation inhibition activity, GPE showed 45% and 71% inhibition of AGS growth at 1,000 μg/mL and 2,000 μg/mL, respectively. GPE inhibited the growth of the breast cancer cells MCF-7 effectively at low concentration and showed 78% and 90% inhibitions of MCF-7 growth at 200 μg/mL and 500 μg/mL , respectively. GPE showed very significant antiproliferation effect on liver cancer cell line Hep3B and inhibited Hep3B cell growth by 57% at 100 μg/mL, and the inhibition's rate increased up to 87% at 500 μg/mL. Antiproliferation effect of GPE on colorectal cancer cell HT-29 showed 15% reduction of HT-29 cell growth at 200 μg/mL and the growth rate was reduced in a dose dependent manner up to 1,000 μg/mL. These results indicated that GPE had high antiproliferation effects on breast and liver cancer cell lines at low concentrations (200 μg/mL), and by higher concentrations over 500 μg/mL, GPE inhibited the growth of A549 and HT-29. The results of our study suggested the potential use of garlic peels for use as an excellent antiproliferative substance for human cancer cells. Key words：antiproliferation, garlic peel, ethanol extract, human cancer cell line

Quality characteristics of garlic peel according to processing methods

“…약 1.5배 높다고 보고되어 있으며 (Nuutila 등, 2003), 총 플라보노이드 함량은 약 3배 정도 높다(Shin과 Kim, 2004a) 고 알려져 있다. 또한, 마늘 껍질 추출물은 항산화 효과뿐 만 아니라 간암, 유방암 등 4종의 암세포 증식 억제 활성 (Son, 2017), 체내 지질 감소 및 항혈전 효과(Shin과 Kim, 2004b)와 같은 기능이 있다고 보고되었다. 이처럼 마늘껍 질은 인편 못지않은 기능성 성분을 함유하고 있어 기능성 소재로 활용가치가 높은 부산물이다.…”