This review discusses the antimicrobial potential of Curcuma longa, a plant traditionally recognized for its medicinal properties. The emerging concern over antimicrobial resistance, coupled with the adverse effects of synthetic drugs, necessitates an exploration of plant-based natural antimicrobials. Curcuma longa, commonly known as turmeric, provides a compelling case with its broad spectrum of antimicrobial activity. The review first delves into the phytochemical composition of Curcuma longa, focusing on its primary bioactive compounds, the curcuminoids, with curcumin being the most prominent. These compounds, along with essential oils and polysaccharides, contribute significantly to the antimicrobial properties of the plant.