Antipolymer antibody is not associated with fibromyalgia in Korean female patients

Lee, Shin-Seok; Yoon, Hyun‐Jung; Park, Yong-Wook

doi:10.1007/s00296-006-0174-8

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…Like other reports [ 10 , 11 ], we found that the APA assay was negatively associated with age, probably because APA is not associated with autoimmune diseases and with a T-helper-2 response. We found a positive correlation between APA and IL-1 levels in the patient subgroup with APA >30 U, which might be associated with an immunological response to environmental agents in some way related to polymerized acrylamide.…”

Section: Discussionsupporting

confidence: 87%

“…Wilson and colleagues [ 9 ], like the present study, observed higher APA levels with the presence of more severe symptoms, while other authors [ 11 ] showed a downward trend as the symptom severity increased.…”

Section: Discussionsupporting

confidence: 55%

“…We did not find differences of seropositivity between FM patients and control individuals but did observe that patients with moderate and severe symptoms exhibited qualitatively higher levels of APA, even if not statistically significant, with respect to patients with mild symptoms. Lee and colleagues [ 11 ] also did not find differences between Korean FM patients and control individuals, but reported a lower percentage of seropositivity (7.2%). Wilson and colleagues [ 9 ], on the contrary, studying an American population, found a higher percentage of seropositivity in FM patients (47%) while the percentage reported for control individuals was similar to ours.…”

Section: Discussionmentioning

confidence: 97%

“…Because of the suggested similarities between FM and reported symptoms by patients with silicone gel-filled breast implants, one of us examined the association of APA and FM and found that 47% of patients in a general rheumatological setting in the United States were seropositive for the presence of APA [ 9 ]. Consequently, other researchers began to investigate the APA seroactivity in patients with FM, finding controversial data [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Antipolymer antibody in Italian fibromyalgic patients

et al. 2007

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The objectives of the present study were to evaluate the presence of antipolymer antibody (APA) seropositivity in 285 Italian patients affected by primary fibromyalgia (FM) and to verify whether APA levels correlate with disease severity and with cytokine levels.APA levels were determined on serum samples by an indirect ELISA kit that detects IgG APA. Cytokines (IL-1, IL-6, IL-8, IL-10 and TNFα) were measured by ELISA in plasma. The impact of FM on the quality of life was estimated using the Fibromyalgia Impact Questionnaire, while pain severity was evaluated using a visual analogic scale. Patients were also characterized by the presence of tiredness, stiffness, nonrestorative sleep, anxiety, depression, tension headache, irritable bowel syndrome, temporomandibular dysfunction and Raynaud's phenomena.Using a cut-off value of 30 U, APA-positive values were detected in 60 FM patients (21.05%) and in 15 healthy control individuals (15.00%) without significant differences among their levels or the percentage of seropositivity. FM patients with moderate and severe symptoms had slightly higher APA levels with respect to patients with mild symptoms. APA-seropositive patients exhibited significant correlations between APA levels and the Fibromyalgia Impact Questionnaire estimate (P = 0.042), tiredness (P = 0.003) and IL-1 levels (P = 0.0072).In conclusion, APA cannot be considered a marker of disease in Italian FM patients. The presence of APA, however, might permit the identification of a subset of FM patients with more severe symptoms and of patients who may respond differently to different therapeutic strategies.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Antipolymer antibody in Italian fibromyalgic patients

et al. 2007

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Serum hyaluronic acid levels do not explain morning stiffness in patients with fibromyalgia

et al. 2010

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To investigate the serum levels of hyaluronic acid (HA) in Korean female patients with fibromyalgia (FM) and correlate these levels with variables of disease severity including morning stiffness, we measured HA serum levels in 69 FM patients, 72 rheumatoid arthritis (RA) patients, and 71 healthy controls by enzyme-linked binding protein assay. The serum levels of HA in FM patients did not differ from those in the age-matched controls, whereas HA levels were significantly higher in RA patients than in FM patients and controls (both P < 0.001). With a cut-off value of 75 ng/mL, the prevalence of seropositivity was higher in RA patients (59.7%) than in FM patients (26.1%) or controls (14.1%; both P < 0.001). There were no differences in seropositivity between FM patients and controls, or between FM patients with severe symptoms and those with mild symptoms. The HA levels in FM patients were significantly correlated with age, age at diagnosis, age at symptom development, disease duration, symptom duration, and level of education. There were no correlations between HA levels and morning stiffness, tender point counts and scores, or Fibromyalgia Impact Questionnaire, State-Trait Anxiety Inventory, and Beck Depression Inventory scores. In our patients, the serum HA levels were not increased and did not reflect disease severity. These results suggest that serum HA is not a useful laboratory marker for diagnosis and assessment of FM.

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Fibromyalgia: An update and immunological aspects

Paiva

Costa²,

Scheinberg

2008

Current Science Inc

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Fibromyalgia syndrome (FMS) is now understood as a chronic pain syndrome, and recent evidence indicates it is not a pure psychosomatic disorder. We review the current knowledge in FMS pain pathways, focusing on the central system sensitization phenomenon and the abnormalities in the inhibitory pain systems. Chronic headache is one of the most common symptoms in FMS, and better knowledge of their common pathophysiologic features can help us understand both conditions better. These features include the nerve growth factor actions and failure of the endocannabinoid system. In addition, we review new immunological aspects of FMS, both in their humoral (autoantibodies, antipolymer antibodies) and cytokine (interleukin-2) aspects.

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Antipolymer antibody is not associated with fibromyalgia in Korean female patients

Cited by 4 publications

References 27 publications

Antipolymer antibody in Italian fibromyalgic patients

Antipolymer antibody in Italian fibromyalgic patients

Serum hyaluronic acid levels do not explain morning stiffness in patients with fibromyalgia

Fibromyalgia: An update and immunological aspects

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