Fibromyalgia: An update and immunological aspects

Paiva, Eduardo S.; Costa, Evelin Diana Goldenberg; Scheinberg, Morton

doi:10.1007/s11916-008-0054-x

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…Even though fibromyalgia is not an inflammatory disease, there is great interest in the study of cytokines in its pathophysiology, since these mediators are related to nociceptive sensitization (3). Adipocytes produce several substances that act as inflammatory mediators (4), including adipokines (or adipocytokines), which are cytokine-like substances mainly produced by the adipose tissue, such as leptin, adiponectin, and resistin (5).…”

Section: Introductionmentioning

confidence: 99%

Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity

Paiva

Andretta

Batista

et al. 2017

Arch. Endocrinol. Metab.

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Objectives: The objectives of this study were to evaluate the serum levels of adipokines in women with fibromyalgia with and without overweight/obesity, and to correlate the adipokines levels with clinical parameters associated with fibromyalgia and adipose tissue mass (body fat). Subjects and methods: The study included 100 women divided into four groups: (a) fibromyalgia and overweight/obesity; (b) fibromyalgia and normal weight; (c) controls and overweight/obesity; and (d) controls and normal weight. Patients and controls were evaluated for clinical, anthropometric, and fibromyalgia-related parameters. Assessments included serum levels of leptin, adiponectin, monocyte chemoattractant protein-1 (MCP-1), and C-reactive protein (CRP). Levels of adipokines were further adjusted for fat mass. Results: Fibromyalgia patients with overweight/obesity or normal weight had no differences in clinical parameters. Unadjusted leptin levels were lower in fibromyalgia patients than controls, a finding that was more remarkable in fibromyalgia patients with overweight/obesity. Leptin levels had no correlation with clinical parameters of fibromyalgia or inflammation markers (MCP-1 and CRP), and adiponectin levels showed no difference between groups. Conclusions: No correlation was observed between adjusted leptin levels and clinical parameters of fibromyalgia. Patients with fibromyalgia and overweight/obesity presented lower levels of leptin than controls with overweight/ obesity. Arch Endocrinol Metab. 2017;61(3):249-56.

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Section: Introductionmentioning

confidence: 99%

Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity

Paiva

Andretta

Batista

et al. 2017

Arch. Endocrinol. Metab.

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“…Fibromyalgia syndrome (FMS) is an incompletely understood chronic pain condition accompanied by symptoms like sleep disturbance, depression or fatigue (Clauw 2015 ; Clauw et al 2011 ; Häuser et al 2015 ). Pathophysiological mechanisms in the central and peripheral nervous system as well as psychological factors have been shown to play a role (Afari et al 2014 ; Clauw 2015 ; Leinders et al 2016 ; Paiva et al 2008 ; Park and Lee 2017 ; Sluka and Clauw 2016 ; Staud and Smitherman 2002 ; Üçeyler et al 2013 ; Zimmermann 1991 ). There is large heterogeneity of patient profiles in FMS patients, in particular regarding coping strategies (Alok et al 2014 ; Kengen-Traska et al 2012 ; Loevinger et al 2012 ; Stoffel et al 2013 ; Tommaso et al 2014 ; Triñanes et al 2014 ; Yim et al 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Relevance of Religiosity for Coping Strategies and Disability in Patients with Fibromyalgia Syndrome

et al. 2021

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Coping strategies are essential for the outcome of chronic pain. This study evaluated religiosity in a cohort of patients with fibromyalgia syndrome (FMS), its effect on pain and other symptoms, on coping and FMS-related disability. A total of 102 FMS patients were recruited who filled in questionnaires, a subgroup of 42 patients participated in a face-to-face interview, and data were evaluated by correlation and regression analyses. Few patients were traditionally religious, but the majority believed in a higher existence and described their spirituality as “transcendence conviction”. The coping strategy “praying–hoping” and the ASP dimension “religious orientation” (r = 0.5, P < 0.05) showed a significant relationship independent of the grade of religiosity (P < 0.05). A high grade of belief in a higher existence was negatively associated with the choice of ignoring as coping strategy (r = − 0.4, P < 0.05). Mood and affect-related variables had the highest impact on disability (b = 0.5, P < 0.05). In this cohort, the grade of religiosity played a role in the choice of coping strategies, but had no effects on health and mood outcome.

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