Antiplatelet theRapy after Genous EPC-capturing coroNary stenT implantatiOn

Cassese, Salvatore; Galasso, Gennaro; Sciahbasi, Alessandro; Scacciatella, Paolo; Muçaj, Andi; Piccolo, Raffaele; D’Anna, Carolina; Pangrazi, A; Lioy, Ernesto; Marra, Sebastiano; Piscione, Federico

doi:10.1016/j.ijcard.2012.03.052

Cited by 10 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EPCs number and function are inversely correlated with age and common cardiovascular risk factors like diabetes, smoking, hypertension, and hyperlipidemia (Vasa et al, 2001; Hill et al, 2003). Low levels and impaired activity of circulating EPCs have been shown to be an independent predictor of morbidity and mortality in patients with CVD (Dzau et al, 2005), whereas high levels of EPCs have been associated with longer event-free survival from adverse cardiovascular events (Werner et al, 2005; Cassese et al, 2013). Several studies demonstrated that a regular physical activity has a positive effect on the levels of circulating EPCs, by inducing EPCs mobilization from the BM niche (George et al, 2011) and counteracting EPCs impairment in the presence of cardiovascular risk factors (Volaklis et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of physical activity on endothelial progenitor cells (EPCs)

et al. 2014

Self Cite

View full text Add to dashboard Cite

Physical activity has a therapeutic role in cardiovascular disease (CVD), through its beneficial effects on endothelial function and cardiovascular system. Circulating endothelial progenitor cells (EPCs) are bone marrow (BM) derived cells that represent a novel therapeutic target in CVD patients, because of their ability to home to sites of ischemic injury and repair the damaged vessels. Several studies show that physical activity results in a significant increase in circulating EPCs, and, in particular, there are some evidence of the beneficial exercise-induced effects on EPCs activity in CVD settings, including coronary artery disease (CAD), heart failure (HF), and peripheral artery disease (PAD). The aim of this paper is to review the current evidence about the beneficial effects of physical exercise on endothelial function and EPCs levels and activity in both healthy subjects and patients with CVD.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of physical activity on endothelial progenitor cells (EPCs)

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…After ECS, DAPT is advised for at least one month, in contrast with 6 months to 1 year after DES. Therefore, the ECS can be an attractive treatment option for patients with a high risk of bleeding or contra‐indication for DAPT and those who are scheduled for surgery shortly after stent placement .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the ECS can be an attractive treatment option for patients with a high risk of bleeding or contra-indication for DAPT and those who are scheduled for surgery shortly after stent placement [21]. of subjects, with no thrombosis after 9 days post-stenting [25].…”

Section: Future Directionmentioning

confidence: 99%

Five‐year follow‐up of the endothelial progenitor cell capturing stent versus the paxlitaxel‐eluting stent in de novo coronary lesions with a high risk of coronary restenosis

Kalkman

Beijk

Klomp

et al. 2017

Cathet Cardio Intervent

View full text Add to dashboard Cite

show abstract

“…However, a commercially available EPC capture stent (Genous Bio-engineered R stent, OrbusNeich Medical, Fort Lauderdale, Florida, USA) has not demonstrated the ability to reduce neointimal hyperplasia as the designers had expected. The HEALING trials, which assessed the Genous R stent, demonstrated only slight improvements in rapid re-endothelialized intima formation and the need for short-term dual antiplatelet therapy after stent placement; this stent was also found to be noninferior to DES with respect to target lesion revascularization and rate of major adverse cardiac events [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%