Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway

Son, Dong-Ju; Cho, Michael; Jin, Yong-Ri; Kim, Soo-Yeon; Park, Young-Hyun; Lee, Soo‐Hwan; Akiba, Suminori; Sato, Takashi; Yun, Young Won

doi:10.1016/j.plefa.2003.12.004

Cited by 84 publications

(65 citation statements)

References 25 publications

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“…Catechins that have an anti-inflammatory effect are known to have anti-platelet function by inhibiting the liberation of TXA2 precursor 20:4 out of platelet membrane phospholipids and TXA2 synthase activity in collagen-activated platelets 13,27,28) . EGCG has been reported to inhibit collagen-activated Ca 2＋ -dependent PLC-γ2 and TXA2 production 13) .…”

Section: Discussionmentioning

confidence: 99%

Epigallocatechin-3-Gallate Has an Anti-Platelet Effect in a Cyclic AMP-Dependent Manner

Cho

Kim

et al. 2012

JAT

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Aim:In this study, we investigated the effect of (−)-epigallocatechin-3-gallate (EGCG) on cyclic nucleotide production and vasodilator-stimulated phosphoprotein (VASP) phosphorylation in collagen (10 μg/mL)-stimulated platelet aggregation. ]i mobilization and TXA2 production on collagen-induced platelet aggregation. Conclusions: These results strongly indicate that EGCG is a beneficial compound elevating cAMP level in collagen-platelet interaction, which may result in the prevention of platelet aggregationmediated thrombotic diseases.

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Section: Discussionmentioning

confidence: 99%

Epigallocatechin-3-Gallate Has an Anti-Platelet Effect in a Cyclic AMP-Dependent Manner

Cho

Kim

et al. 2012

JAT

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“…Many of the studies on platelet aggregation have been carried out using various animal platelets. In addition to showing that green tea catechins were involved in inhibition of platelet aggregation, studies suggested that catechins may affect several cellular targets that are related to platelet activation, including: through the arachadonic acid pathway, inhibition of a cytoplasmic increase in calcium, decreased thrombaxane A 2 (TXA 2 ) production, and inhibition of cyclooxygenase-1 (COX)-1 [90][91][92][93]. A study using human platelets concluded that EGCG was able to inhibit platelet activation by adenosine diphosphate (ADP) stimulation, and suppressed the p38 MAPK phosphorylation of heat shock protein 27 (HSP27), which would inhibit the release of pro-thrombotic contents from platelets [94].…”

Section: Platelet Aggregationmentioning

confidence: 99%

An Update on the Health Benefits of Green Tea

Reygaert

2017

Beverages

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Abstract:Green tea, which is produced from the leaves of the Camellia sinensis plant, is one of the most popular beverages worldwide. Over the past 30 years or more, scientists have studied this plant in respect to potential health benefits. Research has shown that the main components of green tea that are associated with health benefits are the catechins. The four main catechins found in green tea are: (−)-epicatechin (EC), (−)-epicatechin-3-gallate (ECG), (−)-epigallocatechin (EGC), and (−)-epigallocatechin-3-gallate (EGCG). Of these four, EGCG is present in the largest quantity, and so has been used in much of the research. Among the health benefits of green tea are: anticarcinogenic, anti-inflammatory, antimicrobial, and antioxidant properties, and benefits in cardiovascular disease and oral health. Research has been carried out using various animal models and cells lines, and is now more and more being carried out in humans. This type of research will help us to better understand the direct benefits of green tea. This review will focus primarily on research conducted using human subjects to investigate the health benefits of green tea.

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“…40 GT polyphenols inhibit the synthesis of potent vasoconstrictors such as thromboxane A2 (TxA2) and prostaglandin D2 (PGD2) generation. 41 The hypothesis that GTE exhibits anti-inflammatory properties has been supported by the findings that intake of GTE significantly reduced serum TNF-a levels. Through this connection, Yang et al 42 suggested GT polyphenols reduce inflammatory responses by attenuating NF-kB activation.…”

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confidence: 99%

Amelioration of gentamicin nephrotoxicity by green tea extract in uninephrectomized rats as a model of progressive renal failure

Salem

Kamel

et al. 2010

Renal Failure

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Rationale: Gentamicin (GM) is an effective antibiotic against severe infection but has limitations related to nephrotoxicity. This study investigates whether green tea extract (GTE), an antioxidant, could ameliorate the nephrotoxic effect of GM in uninephrectomized rats. Objectives: The right kidneys of 40 rats were surgically removed and 1 week later the animals were divided into four groups (n = 10). Group 1 served as control, Group 2 as GTE group, Group 3 as GM group, and Group 4 as GM+GTE group. Kidney function, inflammatory cytokine TNF-a, oxidant and antioxidant parameters of renal tissue, as well as histopathological studies were assessed. Main findings: Injecting uninephrectomized rats with GM induced renal dysfunction as shown by significant elevations in serum creatinine and urea. Serum TNF-a and oxidative stress parameters (superoxide anion and lipid peroxides) were also significantly increased. On the contrary, antioxidative parameters [superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH)] were significantly decreased. Histopathological examination of renal tissue illustrated features of degeneration, marked cellular infiltration, tubular dilatation, and varying degrees of necrosis. GTE given to GM rats reduced these nephrotoxicity parameters. Serum creatinine, urea, and TNF-a were almost normalized in the GM+GTE group. The oxidative stress parameters were significantly decreased and the antioxidative parameters were significantly increased. Conclusion: GTE ameliorates GM-induced nephrotoxicity and oxidative damage by improving antioxidant defense and tissue integrity. Further human studies are necessary to demonstrate the antioxidant effects of GTE on renal diseases. Nevertheless, green tea (GT) may offer an inexpensive, nontoxic, and effective intervention strategy in subjects with a risk for GM-induced nephrotoxicity.

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Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway

Cited by 84 publications

References 25 publications

Epigallocatechin-3-Gallate Has an Anti-Platelet Effect in a Cyclic AMP-Dependent Manner

Epigallocatechin-3-Gallate Has an Anti-Platelet Effect in a Cyclic AMP-Dependent Manner

An Update on the Health Benefits of Green Tea

Amelioration of gentamicin nephrotoxicity by green tea extract in uninephrectomized rats as a model of progressive renal failure

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