Antiplatelet aggregation activity of compounds isolated from Guttiferae species in human whole blood

Jantan, Ibrahim; Yasin, Yusyila Harlina Mohd; Jalil, Juriyati; Murad, Shahnaz; Idris, Muhammad Sum

doi:10.1080/13880200903008641

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Significance Of the Antithrombotic Effect Of Plant Foods And...1

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2020

2023

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“…In context, acetylsalicylic acid inhibited 42 and 31% of platelet aggregation induced by ADP (10 μM) and collagen (2 μg mL −1 ), respectively, at a concentration of 25 μg mL −1 equivalent to 138 μM. 85 Thus, both phenanthrenes and zingerone exhibited a greater antiplatelet effect. Similarly, Zhou et al 41 and Riaz & Khan 33 reported that the extracts of pomegranate and Asiatic bittersweet had a greater in vitro effect than that exhibited by acetylsalicylic acid.…”

Section: Significance Of the Antithrombotic Effect Of Plant Foods And...mentioning

confidence: 87%

Bioactive compounds and functional foods as coadjuvant therapy for thrombosis

Martínez

Campos

2023

Food Funct.

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Section: Significance Of the Antithrombotic Effect Of Plant Foods And...mentioning

confidence: 87%

Bioactive compounds and functional foods as coadjuvant therapy for thrombosis

Martínez

Campos

2023

Food Funct.

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“…This finding explained the stronger binding affinity of GTDC to P2Y12 rather than to the P2Y1 receptor. The structure-activity relationship of chalcone-derived compounds demonstrated that the 4-OH phenolic group and the adjacent geranyl group are essential for the antiplatelet activity in ADP-induced platelet aggregation (Jantan et al 2009;Jantan et al 2010). Coincidentally, both functional groups are present in GTDC and may contribute to antiplatelet activities.…”

Section: Discussionmentioning

confidence: 99%

A geranylated chalcone with antiplatelet activity from the leaves of breadfruit (Artocarpus altilis)

Fakhrudin¹,

Pertiwi²,

Takubessi³

et al. 2020

PHAR

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Platelet plays a crucial role in cardiovascular diseases (CVDs) development. Abnormalities in platelet aggregation provokes thromboembolism, eventually leading to death. In Indonesia, breadfruit (Artocarpus altilis) leaf is traditionally used to treat CVDs. This study aimed to evaluate the antiplatelet activity of A. altilis leaf extract (AAE) and to identify its active compound. A. altilis leaves were extracted with ethanol, and the antiplatelet activity was assessed using ADP-induced platelet aggregation. The major compound was isolated with column chromatography followed by preparative TLC, and the structure was determined on the basis of UV, MS, IR, and NMR spectra. The binding mode of the active compound to platelet receptors was characterized in in silico study. AAE exhibited an antiplatelet activity (IC50 of 252.23 µg/mL). A geranylated chalcone, 2-geranyl-2ʹ,3,3,4ʹ-tetrahydroxydihydrochalcone (GTDC) was identified as the antiplatelet compound (IC50 of 9.09 µM). GTDC actions with P2Y12 platelet receptor involving three amino acid residues.

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Antiplatelet aggregation activity of compounds isolated from Guttiferae species in human whole blood

Cited by 2 publications

References 0 publications

Bioactive compounds and functional foods as coadjuvant therapy for thrombosis

Bioactive compounds and functional foods as coadjuvant therapy for thrombosis

A geranylated chalcone with antiplatelet activity from the leaves of breadfruit (Artocarpus altilis)

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