Antiplasmodial Quinones from the Rhizomes of <i>Kniphofia Foliosa</i>

Induli, Martha; Gebru, Meron; Abdissa, Negera; Akala, Hosea; Wekesa, Ingrid; Boyer, Robert; Heydenreich, Matthias; Murunga, Sylvia I.; Dagne, Ermias; Yenesew, Abiy

doi:10.1177/1934578x1300800920

Cited by 11 publications

(10 citation statements)

References 19 publications

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“…In this review natural products mostly from medicinal plants were considered active when inhibition of parasite growth was equal to or above 30% (the lower limit for moderately active products); those below 30% were considered to be inactive ( Carvalho et al, 1991 ; Andrade-Neto et al, 2003 ; Coutinho et al, 2013 ; Induli et al, 2013 ; Musila et al, 2013 ; Nguta and Mbaria, 2013 ; Bantie et al, 2014 ; Upadhyay et al, 2014 ; Aguiar et al, 2015 ; Rocha e Silva et al, 2015 ; Satish et al, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology

et al. 2021

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Malaria is an endemic disease that affected 229 million people and caused 409 thousand deaths, in 2019. Disease control is based on early diagnosis and specific treatment with antimalarial drugs since no effective vaccines are commercially available to prevent the disease. Drug chemotherapy has a strong historical link to the use of traditional plant infusions and other natural products in various cultures. The research based on such knowledge has yielded two drugs in medicine: the alkaloid quinine from Cinchona species, native in the Amazon highland rain forest in South America, and artemisinin from Artemisia annua, a species from the millenary Chinese medicine. The artemisinin-based combination therapies (ACTs), proven to be highly effective against malaria parasites, and considered as “the last bullet to fight drug-resistant malaria parasites,” have limited use now due to the emergence of multidrug resistance. In addition, the limited number of therapeutic options makes urgent the development of new antimalarial drugs. This review focuses on the antimalarial activities of 90 plant species obtained from a search using Pubmed database with keywords “antimalarials,” “plants” and “natural products.” We selected only papers published in the last 10 years (2011–2020), with a further analysis of those which were tested experimentally in malaria infected mice. Most plant species studied were from the African continent, followed by Asia and South America; their antimalarial activities were evaluated against asexual blood parasites, and only one species was evaluated for transmission blocking activity. Only a few compounds isolated from these plants were active and had their mechanisms of action delineated, thereby limiting the contribution of these medicinal plants as sources of novel antimalarial pharmacophores, which are highly necessary for the development of effective drugs. Nevertheless, the search for bioactive compounds remains as a promising strategy for the development of new antimalarials and the validation of traditional treatments against malaria. One species native in South America, Ampelozyzyphus amazonicus, and is largely used against human malaria in Brazil has a prophylactic effect, interfering with the viability of sporozoites in in vitro and in vivo experiments.

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Section: Methodsmentioning

confidence: 99%

Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology

et al. 2021

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“…The study by Induli et al of the rhizomes of Kniphofia foliosa (Asphodelaceae), growing in Ethiopia, led to the identification of several anthraquinones [85]: the novel 10-acetonylknipholone cyclooxanthrone (81), along with the known knipholone anthrone (82), chryslandicin (83), 10-hydroxy-10-(chrysophanol-7′-yl)-chrysophanol anthrone (84), 10-methoxy-10-(chrysophanol-7′-yl) chrysophanol anthrone (85), asphodelin (86), knipholone (87), isoknipholone (88) knipholone cyclooxanthrone (89), joziknipholone A (90), joziknipholone B (91) and dianellin (92) (Fig. 17).…”

Section: Anthraquinonesmentioning

confidence: 99%

The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019

Bekono

Ntie‐Kang

Onguéné

et al. 2020

Malar J

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Background African Traditional Medicine (ATM) is used for the healthcare of about 80% of the rural populations of the continent of Africa. The practices of ATM make use of plant-products, which are known to contain plant-based secondary metabolites or natural products (NPs), likely to play key roles in drug discovery, particularly as lead compounds. For various reasons, including resistance of strains of Plasmodium to known anti-malarial drugs, local African populations often resort to plant-based treatments and/or a combination of this and standard anti-malarial regimens. Emphasis has been laid in this review to present the anti-malarial virtue of the most recently published phytochemicals or natural products, which have been tested by in vitro and in vivo assays. Methods The data was based on the current version of the African Compound Libraries, which are constantly being updated based on inputs from journal articles and student theses (M.Sc/Ph.D) from African University libraries. Emphasis was laid on data published after 2012. In order to carry out the original data collection, currently being included in the African Compounds Database, individual journal websites were queried using the country names in Africa as search terms. Over 40,000 articles “hits” were originally retrieved, then reduced to about 9000 articles. The retained articles/theses was further queried with the search terms “malaria”, “malarial”, “plasmodium”, “plasmodial” and a combination of them, resulting in over 500 articles. Those including compounds with anti-malarial activities for which the measured activities fell within the established cut off values numbered 55, which were all cited in the review as relevant references. Results and discussion Pure compounds derived from African medicinal plants with demonstrated anti-malarial/antiplasmodial properties with activities ranging from “very active” to “weakly active” have been discussed. The majority of the 187 natural products were terpenoids (30%), followed by flavonoids (22%), alkaloids (19%) and quinones (15%), with each of the other compound classes being less than 5% of the entire compound collection. It was also observed that most of the plant species from which the compounds were identified were of the families Rubiaceae, Meliaceae and Asphodelaceae. The review is intended to continue laying the groundwork for an African-based anti-malarial drug discovery project.

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“…Also, 10-acetonylknipholone cyclooxanthrone showed significant activity against the W2 strain of P. falciparum with an IC 50 value of 3.1 mg/mL. Knipholone anthrone has also exhibited marginal antimalarial activity in an in vivo assay [22].…”

Section: Pharmacological Properties Of K Foliosa Antimalarial Activitymentioning

confidence: 98%

“…Others are anthraquinone dimers asphodelin and chryslandicin, knipholone, knipholone anthrone and a minor phenolic 3,4-dihydroxybenzoic acid. [22] Leaves Acetone Knipholone, chrysophanol, aloe-emodin, islandicin, and aloe-emodin acetate (which contains antileukaemic properties).…”

Section: Pharmacological Properties Of K Foliosa Antimalarial Activitymentioning

confidence: 99%

Kniphofia foliosa Hochst, (Asphodelaceae)

Aladejana

Musara

2021

J. Pharm. Nutr. Sci.

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This review gives the first comprehensive appraisal of Kniphofia foliosa Hochst, from the plant family Asphodelaceae: its botany, ethnomedicinal (with particular emphasis on the African communities), phytochemistry, and pharmacological potential. Particular emphasis is given to the biological and chemical properties. Peer review and literature search were done by conducting a logical and inclusive review. Indigenous cultures have used the plant among different ethnic groups in tropical Africa for medicinal and other purposes. The chemical compounds that have been isolated from K. foliosa include monomeric anthraquinones such as chrysophanol, islandicin, laccaic acid, aloe-emodin, and aloe-emodin acetate, which contain antileukaemic properties; dimeric anthraquinones such as asphodelin, knipholone, and chryslandicin; phenyl anthraquinones and anthrones, including knipholone anthrone, isoknipholone anthrone, knipholone, phenylanthrone knipholone anthrone and anthraquinone isoknipholone; oxanthrones such as isofoliosone and foliosone; and rare dimeric phenylanthraqunones joziknipholones A and B. The pharmacological studies on K. foliosa exhibited antimalarial, antioxidant, antibacterial, anti-HIV-1, and anti-leukotriene activities. From the above, it can be deduced that K. foliosa contains chemical constituents of pharmacological importance, contributing significantly to the development of new medicines.

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Antiplasmodial Quinones from the Rhizomes of Kniphofia Foliosa

Cited by 11 publications

References 19 publications

Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology

Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology

The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019

Kniphofia foliosa Hochst, (Asphodelaceae)

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