Antiplasmodial Diterpenoids and a Benzotropolone from <i>Petradoria pumila</i>

Du, Yongle; Valenciano, Ana Lisa; Goetz, Michael; Cassera, María B.; Kingston, David G. I.

doi:10.1021/acs.jnatprod.8b00135

Cited by 4 publications

(4 citation statements)

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“…The trans configuration of the dihydrobenzofuran moiety of 1 was established based on the NOE correlations from H-7′ to H-9′ and from H-2′ and H-6′ to H-8′ (Figure ). A lignan with a molecular structure identical to that of 1 has previously been reported; however, its absolute configuration was not determined. The optical rotation of 1 was 0, and there were no Cotton effects in its ECD spectrum, suggesting that 1 is a racemic mixture.…”

Section: Resultsmentioning

confidence: 94%

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Acylated Lignans Isolated from Brachanthemum gobicum and Their Trypanocidal Activity

et al. 2019

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Eight isovaleryllignans (1−4 and 8−11), three isovalerylphenylpropanoids (5−7), three known lignans (12− 14), and four known compounds were isolated from an extract of the aerial part of Brachanthemum gobicum. The structures of the isolated compounds were elucidated based on NMR and MS data analyses. The enantiomers of compounds 1−3, 5, 8, and 9 were isolated using chiral-phase HPLC, and the absolute configurations of 1a/1b−3a/3b, 5a/5b, 8a/8b, and 9a/9b were elucidated from their optical rotations and ECD spectra; the other lignans were assumed to be racemic or scalemic by chiralphase HPLC analyses and optical rotation data. Some of the acylated lignans (racemic mixtures) (1−4, 8, 9, and 12−14) exhibited moderate inhibitory activities against Trypanosoma congolense, the causative agent of nagana disease in animals.

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Section: Resultsmentioning

confidence: 94%

“…A voucher specimen (103.29.2.12A) was deposited at the herbarium of the Laboratory of Bioorganic Chemistry and Pharmacognosy, National University of Mongolia. 16 0.1 pentamidine 16 0.2 a IC 50 (μM), treatment was replicated three times for each concentration. b IC 50 value >25 μM.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Acylated Lignans Isolated from Brachanthemum gobicum and Their Trypanocidal Activity

et al. 2019

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“…Greene [Asteraceae] and investigated against P. falciparum to identify their antimalarial activity. Among the diterpenes, 226 showed moderate antiplasmodial activity, with an IC 50 value of 7.3 μM ( Du et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial Diterpenes: Recent Development From Natural Sources

et al. 2022

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Antimicrobial resistance has been posing an alarming threat to the treatment of infectious diseases over the years. Ineffectiveness of the currently available synthetic and semisynthetic antibiotics has led the researchers to discover new molecules with potent antimicrobial activities. To overcome the emerging antimicrobial resistance, new antimicrobial compounds from natural sources might be appropriate. Secondary metabolites from natural sources could be prospective candidates in the development of new antimicrobial agents with high efficacy and less side effects. Among the natural secondary metabolites, diterpenoids are of crucial importance because of their broad spectrum of antimicrobial activity, which has put it in the center of research interest in recent years. The present work is aimed at reviewing recent literature regarding different classes of natural diterpenes and diterpenoids with significant antibacterial, antifungal, antiviral, and antiprotozoal activities along with their reported structure–activity relationships. This review has been carried out with a focus on relevant literature published in the last 5 years following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 229 diterpenoids from various sources like plants, marine species, and fungi are summarized in this systematic review, including their chemical structures, classification, and significant antimicrobial activities together with their reported mechanism of action and structure–activity relationships. The outcomes herein would provide researchers with new insights to find new credible leads and to work on their synthetic and semisynthetic derivatives to develop new antimicrobial agents.

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“…This paper reports the results of a study of the constituents of Galtonia regalis for antiplasmodial activity. This work was carried out as part of an investigation of antiplasmodial plant extracts from the Natural Products Discovery Institute (NPDI) collection. − The Galtonia genus is native to South Africa and is the source of several cytotoxic cholestane glycosides. − There have been no reports of antiplasmodial or antimalarial compounds from members of this genus, and this extract was thus selected for investigation of potential antiplasmodial constituents based on its IC 50 value of <1.25 μg/mL in an antiplasmodial bioassay.…”

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Galtonosides A–E: Antiproliferative and Antiplasmodial Cholestane Glycosides from Galtonia regalis

Martin

Valenciano

et al. 2020

J. Nat. Prod.

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An extract of Galtonia regalis from the Natural Products Discovery Institute showed moderate antiplasmodial activity, with an IC50 value less than 1.25 μg/mL. The two known cholestane glycosides 1 and 2 and the five new cholestane glycosides galtonosides A–E (3–7) were isolated after bioassay-directed fractionation. The structures of the new compounds were determined by interpretation of their NMR and mass spectra. Among these compounds, galtonoside B (4) displayed the most potent antiplasmodial activity, with an IC50 value of 0.214 μM against the drug-resistant Dd2 strain of Plasmodium falciparum.

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Antiplasmodial Diterpenoids and a Benzotropolone from Petradoria pumila

Cited by 4 publications

References 27 publications

Acylated Lignans Isolated from Brachanthemum gobicum and Their Trypanocidal Activity

Acylated Lignans Isolated from Brachanthemum gobicum and Their Trypanocidal Activity

Antimicrobial Diterpenes: Recent Development From Natural Sources

Galtonosides A–E: Antiproliferative and Antiplasmodial Cholestane Glycosides from Galtonia regalis

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