Antimicrobial Diterpenes: Recent Development From Natural Sources

Saha, Poushali; Rahman, Farjana; Hussain, Fahad; Rahman, Sharif; Rahman, Md. Abdur

doi:10.3389/fphar.2021.820312

Cited by 24 publications

(12 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, PLEC and MRC were classified as labdanes, while HAL was classified as a halimane diterpene. Both labdane and halimane diterpenes show a range of antitumor, antibacterial, antiviral, antifungal, antimalarial, anti-inflammatory, anti-ulcerogenic, antihyperlipidemic and hepatogenic activities [ 49 , 50 , 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of the Novel Biological Properties of Diterpenes Isolated from Plectranthus ornatus Codd. In Vitro and In Silico

Sitarek

Kowalczyk

Synowiec

et al. 2022

Cells

View full text Add to dashboard Cite

Plectranthus ornatus Codd, the genus Plectranthus of the Lamiaceae family, has been used as traditional medicine in Africa, India and Australia. Pharmacological studies show the use of this plant to treat digestive problems. In turn, leaves were used for their antibiotic properties in some regions of Brazil to treat skin infections. The present study examines the anti-inflammatory, antioxidant and cytotoxic effects of the halimane and labdane diterpenes (11R*,13E)-11-acetoxyhalima-5,13-dien-15-oic acid (HAL) and 1α,6β-diacetoxy-8α,13R*-epoxy-14-labden-11-one (PLEC) and the forskolin-like 1:1 mixture of 1,6-di-O-acetylforskolin and 1,6-di-O-acetyl-9-deoxyforskolin (MRC) isolated from P. ornatus on lung (A549) and leukemia (CCRF-CEM) cancer cell lines, and on normal human retinal pigment epithelial (ARPE-19) cell line in vitro. Additionally, molecular docking and computational approaches were used. ADMET properties were analysed through SwissADME and proTox-II—Prediction. The results indicate that all tested compounds significantly reduced the viability of the cancer cells and demonstrated no cytotoxic effects against the non-neoplastic cell line. The apoptosis indicators showed increased ROS levels for both the tested A549 and CCRF-CEM cancer cell lines after treatment. Furthermore, computational studies found HAL to exhibit moderate antioxidant activity. In addition, selected compounds changed mitochondrial membrane potential (MMP), and increased DNA damage and mitochondrial copy number for the CCRF-CEM cancer cell line; they also demonstrated anti-inflammatory effects on the ARPE-19 normal cell line upon lipopolysaccharide (LPS) treatment, which was associated with the modulation of IL-6, IL-8, TNF-α and GM-CSF genes expression. Docking studies gave indication about the lowest binding energy for 1,6-di-O-acetylforskolin docked into IL-6, TNF-α and GM-CSF, and 1,6-di-O-acetyl-9-deoxyforskolin docked into IL-8. The ADMET studies showed drug-likeness properties for the studied compounds. Thus, halimane and labdane diterpenes isolated from P. ornatus appear to offer biological potential; however, further research is necessary to understand their interactions and beneficial properties.

show abstract

Section: Discussionmentioning

confidence: 99%

An Evaluation of the Novel Biological Properties of Diterpenes Isolated from Plectranthus ornatus Codd. In Vitro and In Silico

Sitarek

Kowalczyk

Synowiec

et al. 2022

Cells

View full text Add to dashboard Cite

show abstract

“…Thereby, it is expected that the remarkable antimicrobial activity of oridonin made it possible as a promising candidate for the development of novel agents which can be used in food preservation or functional foods. compounds, oridonin is considered the main antibacterial active ingredient in Rabdosia rubescens (Han et al, 2000;Saha et al, 2022;Wei et al, 2022).…”

Section: Traditional Chinese Medicine Rabdosia Rubescensmentioning

confidence: 99%

Antimicrobial activity of oridonin

Zhou

2023

Food Sci. Technol

View full text Add to dashboard Cite

Oridonin is an enantiomer-kaurene tetracyclic diterpenoid compound, which is the main active component of Rabdosia rubescens, a herb used in traditional Chinese medicine. It has been reported to exert anti-tumor, anti-inflammatory, proapoptotic, anti-angiogenic, neuroprotective, and other pharmacological effects. Owing to the overuse of antibiotics, currently, the medical and food industries are facing drug resistance challenges, which have severely impacted food and medical safety. Thus, new antibacterial agents must be identified. As an important active component of Rabdosia rubescens, oridonin has been extensively and deeply studied in antimicrobial aspects. This paper reviews the antimicrobial activity of oridonin and its underlying mechanism. In addition, its safety and application as an antibacterial agent were briefly introduced. Finally, the current problems and challenges of the application of oridonin and the prospects were also elucidated.

show abstract

“…So far, there have been several reports about terpenoid compounds that displayed desired antimicrobial activities [ 68 ]. Among them, the most representative one is undoubtedly artemisinin ( Figure 2 ).…”

Section: Terpenoidsmentioning

confidence: 99%

Biosynthesis Investigations of Terpenoid, Alkaloid, and Flavonoid Antimicrobial Agents Derived from Medicinal Plants

et al. 2022

View full text Add to dashboard Cite

The overuse of antibiotics in the past decades has led to the emergence of a large number of drug-resistant microorganisms. In recent years, the infection rate caused by multidrug-resistant microorganisms has been increasing, which has become one of the most challenging problems in modern medicine. Plant-derived secondary metabolites and their derivatives have been identified to display significant antimicrobial abilities with good tolerance and less adverse side effects, potentially having different action mechanisms with antibiotics of microbial origin. Thus, these phyto-antimicrobials have a good prospect in the treatment of multidrug-resistant microorganisms. Terpenoids, alkaloids, and flavonoids made up the predominant part of the currently reported phytochemicals with antimicrobial activities. Synthetic biology research around these compounds is one of the hotspot fields in recent years, which not only has illuminated the biosynthesis pathways of these phyto-antimicrobials but has also offered new methods for their production. In this review, we discuss the biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents—using artemisinin and oleanolic acid (terpenoids), berberine and colchicine (alkaloids), and baicalin (flavonoids) as examples—around their antimicrobial action mechanisms, biosynthesis pathway elucidation, key enzyme identification, and heterologous production, in order to provide useful hints for plant-derived antimicrobial agent discovery and development.

show abstract

Antimicrobial Diterpenes: Recent Development From Natural Sources

Cited by 24 publications

References 125 publications

An Evaluation of the Novel Biological Properties of Diterpenes Isolated from Plectranthus ornatus Codd. In Vitro and In Silico

An Evaluation of the Novel Biological Properties of Diterpenes Isolated from Plectranthus ornatus Codd. In Vitro and In Silico

Antimicrobial activity of oridonin

Biosynthesis Investigations of Terpenoid, Alkaloid, and Flavonoid Antimicrobial Agents Derived from Medicinal Plants

Contact Info

Product

Resources

About