Antiplasmodial and leishmanicidal activity of biflavonoids from Indian Selaginella bryopteris

Malaria in the renaissance: Remedies from European herbals from the 16th and 17th century

“…Amongst many other substance classes like iridoid glycosides, the genus Viburnum contains biflavones -a class of compounds with high in vitro antiplasmodial activities. Kunert et al (2009) reported very potent in vitro activities and structure activity relationships of eleven biflavanoids against Plasmodium falciparum K1 strain. The in vitro IC 50 s ranged from 0.26 M for heveaflavone to over 9.2 M for amentoflavone.…”

Natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana

“…(Celastraceae), presented activity against Trypanosoma cruzi (IC50 <0.25 μg/mL), Trypanosoma brucei (<0.25 μg/ mL), L. infantum (0.51 μg/mL), and Plasmodium falciparum (0.36 μg/mL) (Maregesi et al, 2010). The biflavonoids 2,3-dihydrohinokiflavone and isoginkgetin showed strong leishmanicidal activity, with IC50 values of 1.6 and 1.9 μM, respectively (Kunert et al, 2008;Weniger et al, 2006). The biflavonoid fukugetin had activity on amastigote of L. amazonensis with IC50 of 3.2 μM, and it is a cysteine and serine proteinase inhibitor Pereira et al, 2011).…”

Total synthesis of ochnaflavone

“…Biflavonoids with anti-inflammatory [1–3], antileishmanial [4–5], antiplasmodial [6–8], antiviral [9] and β-secretase inhibitory [10] activity, amongst others, have been reported. The activity of the biflavonoids is in general much higher than that of the individual monomers [11].…”