Natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana

Secondary Metabolites From Pachystroma Longifolium (Nees) I. M. Johnst (Euphorbiaceae) and Evaluation of Its Extracts as Cathepsins Inhibitors

“…However, isolated compounds did not show activity as cat-K, -L and -V inhibitors. 17 . Rhynedulins A-C and rhynedulinal showed weak inhibitory activity towards rhodesain, the major cathepsin-L like protease in Trypanosoma brucei 18 .…”

Flavonoids as efficient scaffolds: Recent trends for malaria, leishmaniasis, Chagas disease, and dengue

“…From the database searches, 830 (“malaria and flavonoids”: 540; “Chagas disease and flavonoids”: 60; “leishmaniasis and flavonoids”: 124; “dengue and flavonoids”: 106) potentially relevant records were identified, from which 737 were excluded after screening the titles or abstracts. The full reports of 93 articles were acquired: 83 studies related to natural flavonoids (Adinehbeigi, Razi Jalali, Shahriari, & Bahrami, ; Allard et al, ; Anusuya & Gromiha, ; Anusuya & Gromiha, ; Assis et al, ; Azebaze et al, ; Beer et al, ; Cabanillas et al, ; Castro, Barrios, Chinchilla, & Guerrero, ; Cheema et al, ; Cornelio et al, ; Coulerie et al, ; Cunha‐Rodrigues et al, ; Da Rocha et al, ; Da Silva, Maquiaveli, & Magalhães, ; De Monbrison et al, ; De Sousa et al, ; De Sousa et al, ; Dos Reis, Manjolin, Maquiaveli, Santos‐Filho, & da Silva, ; Ezenyi et al, ; Fonseca‐Silva, Inacio, Canto‐Cavalheiro, & Almeida‐Amaral, ; Fonseca‐Silva, Inacio, Canto‐Cavalheiro, Menna‐Barreto, & Almeida‐Amaral, ; Frabasile et al, ; Freitas et al, ; Ganesh et al, ; Gontijo et al, ; Grael, Albuquerque, & Lopes, ; Grecco et al, ; Güida et al, ; Heh et al, ; Houël et al, ; Ichino et al, ; Ijaz, Ahmad, Ahmad, ul Haq, & Wang, ; Inacio, Gervazoni, Canto‐Cavalheiro, & Almeida‐Amaral, ; Ismail & Jusoh, ; Jasmeen et al, ; Jin et al, ; Kapingu et al, ; Kiat et al, ; Kimmel et al, ; Konziase, ; Kraft et al, ; Kraft et al, ; Lage et al, ; Lage et al, ; Lehane & Saliba, ; Leite et al, ; Lu et al, ; Manjolin, dos Reis, Maquiaveli, Santos‐Filho, & da Silva, ; Marín et al, ; Marín et al, ; Mittra et al, ; Moghaddam et al, ; Montenegro, Gonzalez, Ortega‐Barria, & Luis Cubi...…”

“…Further oral administration of EGCG at 100 mg/kg for 30 days reduced significantly the lesion size (0.25 and 0.65 mm for treated and untreated mice, respectively) in mice infected with L. braziliensis promastigotes (Inacio et al, ). In another study, agathisflavone ( 82 ), tetrahydrorobustaflavone ( 83 ), and quercetin ( 34 ) showed inhibitory effects against rCPB2.8 proteinase from L. mexicana , with IC 50 values 0.43, 2.20, and 18.03 μM, respectively (De Sousa et al, ). Beer et al () evaluated the antileishmanial activity of three compounds named as cirsimaritin ( 84 ), 5‐desmethylsinensetin ( 85 ), and eupatorin ( 86 ) isolated from the aerial parts of Stevia satureifolia var.…”

Natural Products as Cathepsin Inhibitors

“…The different species of parasite can lead to cutaneous leishmaniasis, mucocutaneous leishmaniasis, or visceral leishmaniasis [73]. In a recently published work, de Sousa et al [75] tested in vitro activity of some flavonoids and triterpenes isolated from plants against recombinant cathepsin L-like rCPB2.8 from L. mexicana, which is an isoform without the C-terminal extension that has been used as a target in the search for new leishmanicidal compounds [76]. In a recently published work, de Sousa et al [75] tested in vitro activity of some flavonoids and triterpenes isolated from plants against recombinant cathepsin L-like rCPB2.8 from L. mexicana, which is an isoform without the C-terminal extension that has been used as a target in the search for new leishmanicidal compounds [76].…”