Antiplasmodial and larvicidal flavonoids from Derris trifoliata

Yenesew, Abiy; Twinomuhwezi, H; Kabaru, J. M.; Akala, HM; Kiremire, Bernard T.; Heydenreich, Matthias; Peter, MG; Eyase, F; Waters, NC; Walsh, DS

doi:10.4314/bcse.v23i3.47665

Cited by 25 publications

(21 citation statements)

References 8 publications

(11 reference statements)

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“…The hydroxylated olefinic group attached to benzene showed chemical shifts at δ 21.5 (C-1´´´), δ 122.5 (C-2´´´), δ 25.8 (C-4´´´) and δ 17.8 (C-5´´´). Most chemical shifts were in close agreement with those of lupinifolin (Yenesew et al, 2009).…”

Section: Compoundsupporting

confidence: 69%

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Stem bark extracts of Erythrina excelsa (BAK) and their biological activities

Ombuna¹,

Machocho²,

Keru³

et al. 2016

J. Med. Plants Res.

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The species is known from Southern Nyanza, Migori in Kenya. The extraction of the stem bark was done sequentially using organic solvents starting with the least polar; n-hexane then dichloromethane, ethyl acetate and finally the most polar methanol. Antibacterial and antifungal activities of the crude extract and that of isolated compounds from the stem bark of E. excelsa were investigated. The crude extracts had substantial activity against the tested micro-organisms. Methanol extract was highly active with inhibition zones of 15 mm against S. aureus and 14 mm against both B. subtillis and E. coli. Ethyl acetate and dichloromethane had mild activity. In antifungal test, methanol extract had highest activity of 15 mm against A. niger and 13 mm against C. albicans. Dichloromethane extract was also active with inhibition zones of 14 mm against A. niger and 12 mm against C. albicans while ethyl acetate had mild activity. A total of five compounds were isolated; glutinosalactone A (1), glutinosalactone B (2), lupinifolin (3), sitosterol (4) and 3β-stigimasterol (5). The compounds were active against the bacterial and fungal test strains used. Glutinosalactone A (1) had an activity of 15 mm against A. niger, 11 mm against both B. subtillis and S. aureas. Glutinosalactone B (2) had a high activity of 11 mm in both B. subtillis and C. albicans. and lupinifolin (3) had mild activity of 9 mm against both A. niger and C. albicans. Stigimasterol and sitosterol had mild activity of 8 mm against A. niger.

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Section: Compoundsupporting

confidence: 69%

“…The eleventh signal was identified as a proton singlet δ 1.65 (6H, s, H-4´´´/ H-5´´´). The twelfth signal was assigned as δ 1.45 (3H, s, H-Me 2 ) (Yenesew et al, 2009). The 13 C NMR spectrum showed 21 carbon signals.…”

Section: Compoundmentioning

confidence: 99%

Stem bark extracts of Erythrina excelsa (BAK) and their biological activities

Ombuna¹,

Machocho²,

Keru³

et al. 2016

J. Med. Plants Res.

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“…Vasconcelos et al studied the larvicidal activity of the extracts obtained from the leaves, stems, pods and roots of Tephrosia toxicaria, out of which the α-toxicarol showed the best larvicidal activity (LC50 = 24.55 μg/mL) (Vasconcelos et al, 2009). The compounds rotenone, deguelin, tephrosin and 6,7-dimethoxy-4-chromone, isolated from various parts of Derris trifoliate, showed a LC50 of 0.5, 1.6, 1.5 and 13.4 μg/L, respectively (Yenesew et al, 2009).…”

Section: Concentrations (μG/ml)mentioning

confidence: 99%

Extract of Bowdichia virgilioides and maackiain as larvicidal agent against Aedes aegypti mosquito

Bezerra-Silva

Santos

et al. 2015

Experimental Parasitology

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“…According to Sylvie Morel [11] the role of the flavonoids in the interactions plant-insects is very largely accepted. In practice the rotinoids, and in particular the rotenone were largely studied for their insecticidal activity.The degueline and the tephrosin (rotinoïdes) seem good parricides against Aedes aegypti, [12]. Lastly, some pterocarpans have insecticidal properties against Anopheles gambiae (neodulin, 4-méthoxynéoduline) [13].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Test and Larvicidal Activity of Three Organic Extracts Exits of the Stems of Indigofera pilosa on Larvae of Mosquitoes

Ndiaye¹,

Diop²,

Diouf³

2017

OALib

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In the search for alternative method beside the use of dangerous insecticides for health and the environment, the vegetable kingdom offers many possibilities. Work is carried out in this direction and showed an effectiveness of the extracts of plants. Our results indicate that the chloroformic contents present a better larvicidal activity than the other extracts. In addition, the analysis by Thin Layer Chromatography (TLC) of the three extracts of stems showed their wealth of flavonic compounds before compounds, alkaloids and tannins thus suggesting a correlation between the larvicidal activity and the contents in secondary metabolites of stems.

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Antiplasmodial and larvicidal flavonoids from Derris trifoliata

Cited by 25 publications

References 8 publications

Stem bark extracts of Erythrina excelsa (BAK) and their biological activities

Stem bark extracts of Erythrina excelsa (BAK) and their biological activities

Extract of Bowdichia virgilioides and maackiain as larvicidal agent against Aedes aegypti mosquito

Phytochemical Test and Larvicidal Activity of Three Organic Extracts Exits of the Stems of Indigofera pilosa on Larvae of Mosquitoes

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