Antiplasmodial and Antioxidant Activities of Saye: A Traditional Herbal Remedy for Malaria

Da, Ollo; Coulibaly, Maminata Traoré; Yerbanga, Serge; Koama, Benjamin Kouliga; Ouédraogo, Noufou; Tamboura, S.; Dakuyo, Z.; Sekhoacha, Mamello; Nikiema, Jean‐Baptiste; Ouédraogo, GA; Matsabisa, Motlalepula G.; Ouédraogo, J. B.

doi:10.3923/ajbmb.2014.155.166

Cited by 6 publications

(1 citation statement)

References 18 publications

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“…Thus, studies have been carried out with a view to seeking both plants with antioxidant and antimalarial potential. This is the case with the work of Saliq et al [11] or Sulistyaningsih et al [12] like so many others [13][14][15][16]. Another advantage of this approach is that it allows the discovery of new antimalarial molecules with new mechanisms of action likely to overcome the resistance problems facing current antimalarials [17,18].…”

Section: Introductionmentioning

confidence: 98%

Phytochemical screening and antioxidant activity of methanolic extracts of 53 antimalarial plants from Bagira in Eastern DR Congo

Chiribagula¹,

Bakari²,

Ndjolo³

et al. 2020

GSC Biol. and Pharm. Sci.

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A previous study inventoried 53 plants used in traditional medicine in Bagira in Eastern Democratic Republic of Congo (DRC) in the management of malaria. During malaria disease, oxidative stress is responsible for the worsening of the patient's condition. This study aims to identify phytochemical groups and to evaluate antioxidant activity of 53 plants used in traditional medicine in Bagira to treat malaria. The phytochemical screening was carried out by conventional reactions in solution and antioxidant activity used in vitro method with 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). Chemical screening has identified secondary metabolites with both antimalarial and antioxidant potential such as coumarins, steroids, saponins, tannins and terpenoids in more than 70% of plants. Antioxidant screening revealed for the first-time antioxidant activity of 18 plants, among which Dalbergia katangensis, Dialium angolense and Solanecio cydoniifolius with IC50 ≤ 1.6 µg / mL having the highest activities. This study shows that among plants used as antimalarial in Bagira several possess antioxidant power and contain many of groups presumed to be both antioxidant and antimalarial. This suggests that further studies continue to isolate compounds responsible for the proven activity.

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