Antiplasmodial Alkaloids from the Australian Bryozoan <i>Amathia lamourouxi</i>

Kleks, Guy; Holland, Darren C; Kennedy, Emily K.; Avery, Vicky M.; Carroll, Anthony Richard

doi:10.1021/acs.jnatprod.0c00929

Cited by 14 publications

(9 citation statements)

References 36 publications

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“…We have recently published the structures of several new brominated alkaloids isolated from the bryozoan Amathia lamourouxi . 48 To further test the application of this dereplication methodology, we acquired DOSY data for both the free bases and TFA salts of ( 70 and 71 ) and K ( 72 and 73 ) and the free base of volutamine F ( 74 ). Their D pre vs. D exp were all within 5.5% error.…”

Section: Resultsmentioning

confidence: 99%

Natural products dereplication by diffusion ordered NMR spectroscopy (DOSY)

et al. 2021

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Section: Resultsmentioning

confidence: 99%

Natural products dereplication by diffusion ordered NMR spectroscopy (DOSY)

et al. 2021

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“…Compound 186 was isolated from Amathialamourouxi, a bryozoan found in rock pools. It is a simpler molecule; its name is 2,5-dibromo-1-methyl-1 H -indole-3-carbaldehyde [ 54 ]. Compounds 187 to 195 are monoterpenoid indole alkaloids that were extracted from the leaves of Tabernaemontana pachysiphon .…”

Section: Isolation Of Novel Indole Alkaloidsmentioning

confidence: 99%

Indole-Containing Natural Products 2019–2022: Isolations, Reappraisals, Syntheses, and Biological Activities

et al. 2022

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Indole alkaloids represent a large subset of natural products, with more than 4100 known compounds. The majority of these alkaloids are biologically active, with some exhibiting excellent antitumor, antibacterial, antiviral, antifungal, and antiplasmodial activities. Consequently, the natural products of this class have attracted considerable attention as potential leads for novel therapeutics and are routinely isolated, characterized, and profiled to gauge their biological potential. However, data on indole alkaloids, their various structures, and bioactivities are complex due to their diverse sources, such as plants, fungi, bacteria, sponges, tunicates, and bryozoans; thus, isolation methods produce an incredible trove of information. The situation is exacerbated when synthetic derivatives, as well as their structures, bioactivities, and synthetic schemes, are considered. Thus, to make such data comprehensive and inform researchers about the current field’s state, this review summarizes recent reports on novel indole alkaloids. It deals with the isolation and characterization of 250 novel indole alkaloids, a reappraisal of previously reported compounds, and total syntheses of indole alkaloids. In addition, several syntheses and semi-syntheses of indole-containing derivatives and their bioactivities are reported between January 2019 and July 2022.

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“…During a high-throughput screening of an Australian marine invertebrate extract library against Plasmodium falciparum, Kleks et al [62] isolated 2,5-dibromo-1-methyl-1Hindole-3-carbaldehyde (165) (Figure 18) from samples of a bryozoan Amathia lamourouxi, collected from the rock pools of Woolgoolga and as storm debris from Korora Beach, Coffs Harbour, New South Wales, Australia.…”

Section: Simple Indole Alkaloidsmentioning

confidence: 99%

Marine-Derived Indole Alkaloids and Their Biological and Pharmacological Activities

Wibowo¹,

Ahmadi²,

Rahmawati³

et al. 2021

Marine Drugs

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Novel secondary metabolites from marine macroorganisms and marine-derived microorganisms have been intensively investigated in the last few decades. Several classes of compounds, especially indole alkaloids, have been a target for evaluating biological and pharmacological activities. As one of the most promising classes of compounds, indole alkaloids possess not only intriguing structural features but also a wide range of biological/pharmacological activities including antimicrobial, anti-inflammatory, anticancer, antidiabetic, and antiparasitic activities. This review reports the indole alkaloids isolated during the period of 2016–2021 and their relevant biological/pharmacological activities. The marine-derived indole alkaloids reported from 2016 to 2021 were collected from various scientific databases. A total of 186 indole alkaloids from various marine organisms including fungi, bacteria, sponges, bryozoans, mangroves, and algae, are described. Despite the described bioactivities, further evaluation including their mechanisms of action and biological targets is needed to determine which of these indole alkaloids are worth studying to obtain lead compounds for the development of new drugs.

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Antiplasmodial Alkaloids from the Australian Bryozoan Amathia lamourouxi

Cited by 14 publications

References 36 publications

Natural products dereplication by diffusion ordered NMR spectroscopy (DOSY)

Natural products dereplication by diffusion ordered NMR spectroscopy (DOSY)

Indole-Containing Natural Products 2019–2022: Isolations, Reappraisals, Syntheses, and Biological Activities

Marine-Derived Indole Alkaloids and Their Biological and Pharmacological Activities

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