Antiplasmodial activity of <i>Setaria megaphylla</i>

Okokon, Jude E.; Ubulom, Pme; Udokpoh, Aniekan E.

doi:10.1002/ptr.2059

Cited by 13 publications

(10 citation statements)

References 5 publications

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“…They are: Cylicodiscus gabunensis (Okokon et al, 2006b), Uvaria chamae and Hippocratea africana (Okokon et al, 2006a), Enantia chlorantha and Cymbopogon giganteus (Agbaje and Onabanjo, 1991;Kimbi and Fagbenro-Beyioku, 1996), Cymbopogon citratus and Ocimum gratissimum (Tchoumbougnang et al, 2005), Cassia singueana (Adzu et al, 2003), Stachytarpheta cayennensis (Okokon et al, 2008), Striga hermonthica and Tapinanthus sessilifolius (Okpako and Ajaiyeoba, 2004), Tetrapleura tetraptera (Okokon et al, 2007b), Setaria megaphylla (Okokon et al, 2007c), Phyllanthus amarus (Dapper et al, 2007), Homalium letestui (Okokon et al, 2006c) and the plant formula 'Agbo-Iba' shown to protect mice against Plasmodium yoelii nigeriensis infection; the herbs used in this formula were decocted for 3 h and then administered to mice orally to evaluate the prophylactic and curative activities. Although the 'Agbo-Iba' formula was prophylactic and had no apparent significant side effects in mice, the formula had no curative activity against established infection (Nwabuisi, 2002).…”

Section: Scientific Authentication Of Antimalarial Activities Of Nigementioning

confidence: 99%

Potential antimalarials from Nigerian plants: A review

Adebayo

Krettli

2011

Journal of Ethnopharmacology

209

162

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Malaria, caused by parasites of the genus Plasmodium, is one of the leading infectious diseases in many tropical regions, including Nigeria, a West African country where transmission occurs all year round. Many of the inhabitants use plants as remedies against fever and other symptoms of acute malaria, as reported herein. Some of these plants have their antimalarial efficacies scientifically demonstrated and the active compounds isolated with their probable mechanisms of action studied. Medicinal plants are used to treat diseases also where the biodiversity of plants occur in parallel with endemic transmission of malaria. This review focuses on medicinal plants which are used to treat malaria in Nigeria, and on antimalarial testing of extracts and purified compounds from plants. Some show intense activity against malaria parasites in vitro and in experimentally infected mice. The search for new drugs based on plants is important due to the emergence and widespread of chloroquine-resistant and multiple drug-resistant malaria parasites, which require the development of new antimalarials. An acquaintance with antimalarial plants may be a springboard for new phytotherapies that could be affordable to treat malaria, especially among the less privileged native people living in endemic areas of the tropics, mostly at risk of this devastating disease.

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Section: Scientific Authentication Of Antimalarial Activities Of Nigementioning

confidence: 99%

Potential antimalarials from Nigerian plants: A review

Adebayo

Krettli

2011

Journal of Ethnopharmacology

209

162

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“…Cynodon dactylon, commonly known as bermudagrass or arugampullu in Tamil Nadu, India, possesses various medicinal properties such as antimicrobial, antiviral activity (Dhar et al 1968). The antimalarial activity of an ethanol leaf extract of Setaria megaphylla (Poaceae) was studied in vivo in mice infected with Plasmodium berghei berghei during early and established infections (Okokon et al 2007). The roots and tubers of Gloriosa superba, an ornamental climbing herb native of tropical Asia and Africa, have been used in traditional Indian medicine for the treatment of gout, in diseases of skin, and several other purposes (Finnie and Staden 1994).…”

Section: Introductionmentioning

confidence: 99%

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

Bagavan¹,

Rahuman²,

Kaushik

et al. 2010

Parasitol Res

121

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Malaria is a major global public health problem, and the alarming spread of drug resistance and limited number of effective drugs now available underline how important it is to discover new antimalarial compounds. In the present study, ten plants were extracted with ethyl acetate and methanol and tested for their antimalarial activity against chloroquine (CQ)-sensitive (3D7) and CQ-resistant (Dd2 and INDO) strains of Plasmodium falciparum in culture using the fluorescence-based SYBR Green assay. Plant extracts showed moderate to good antiparasitic effects. Promising antiplasmodial activity was found in the extracts from two plants, Phyllanthus emblica leaf 50% inhibitory concentration (IC₅₀) 3D7: 7.25 μg/mL (ethyl acetate extract), 3.125 μg/mL (methanol extract), and Syzygium aromaticum flower bud, IC₅₀ 3D7:13 μg/mL, (ethyl acetate extract) and 6.25 μg/mL (methanol extract). Moderate activity (30-75 μg/mL) was found in the ethyl acetate and methanol extracts of Abrus precatorius (seed) and Gloriosa superba (leaf); leaf ethyl acetate extracts of Annona squamosa and flower of Musa paradisiaca. The above mentioned plant extracts were also found to be active against CQ-resistant strains (Dd2 and INDO). Cytotoxicity study with P. emblica leaf and S. aromaticum flower bud, extracts showed good therapeutic indices. These results demonstrate that leaf ethyl acetate and methanol extracts of P. emblica and flower bud extract of S. aromaticum may serve as antimalarial agents even in their crude form. The isolation of compounds from P. emblica and S. aromaticum seems to be of special interest for further antimalarial studies.

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“…The percentage parasitaemia was determined by counting the number of parasitized red blood cells against the total number of red blood cells. The inoculum was prepared by diluting 2 mL of the parasitized blood with 10 mL of sterile normal saline, to obtain the final inoculum of 0.2 mL (1.0 ×10 7 ), which is the standard inoculum for the infection of a single mouse (23).…”

Section: Animalsmentioning

confidence: 99%

Antiplasmodial activity of methanol leaf extract of Citrus aurantifolia (Christm) Swingle

Ettebong

Ubulom

Etuk

2019

J Herbmed Pharmacol

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Introduction: Citrus aurantifolia (Christm) is a plant used for the treatment of various ailments including malaria. This study aimed to evaluate the in vivo antiplasmodial efficacy of methanol leaf extract of C. aurantifolia in Swiss albino mice. Methods: The median lethal dose (LD50) was determined by intraperitoneal administration of different doses of the extract (100–4000 mg/kg) to 6 groups of 3 mice each and the animals were observed for 24 hours for physical signs of toxicity. To evaluate the antiplasmodial activity of the extract, three models were used: suppressive, curative and repository. Doses of the extract used were 320, 640 and 960 mg/kg/d in mice, with Chloroquine (5 mg/kg/d) as standard drug. Pyrimethamine (1.2 mg/kg/d) was used as the standard drug for the repository test and distilled water (10 mL/kg/d) as control in all models. Results: In all models, the low dose (320 mg/kg) of the extract produced the highest chemosuppressive effects in all models (P < 0.001). Mice treated with extract lived longer than those in the control group (P < 0.001). Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, tannins and cardiac glycosides and the LD50 of 3280 mg/kg ± 0.01 shows that the extract has low toxicity. Conclusion: The result of this study shows that C. aurantifolia has antiplasmodial properties which support its use in ethnomedicine in the treatment of malaria.

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Antiplasmodial activity of Setaria megaphylla

Cited by 13 publications

References 5 publications

Potential antimalarials from Nigerian plants: A review

Potential antimalarials from Nigerian plants: A review

In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum

Antiplasmodial activity of methanol leaf extract of Citrus aurantifolia (Christm) Swingle

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