Antiphospholipid Syndrome Associated with Malignant Mesothelioma Presenting with Superior Vena Cava Thrombosis: A Case Report

Özkan, Metin; Eser, Bülent; Er, Özlem; Altuntaş, Fevzi; Coşkun, Ramazan; Topsakal, Ramazan; Mavili, Ertuğrul; Kala, Mehtap; Altınbaş, Mustafa

doi:10.1177/107602960401000413

Cited by 13 publications

(10 citation statements)

References 18 publications

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“…In fact, only one case of SLE as a syndrome related to PM has been described since 1980 [5]. Instead, the association of PM or peritoneal mesothelioma with inflammatory myopathies, seronegative rheumatoid arthritis, and some atypical vasculitis has been described and reported as paraneoplastic syndromes, although scleroderma-like and SLE-like syndromes (especially subacute cutaneous SLE) have also been reported [7–12]. …”

Section: Discussionmentioning

confidence: 99%

A second case of pericardial mesothelioma mimicking systemic lupus erythematosus in the literature in over 30 years: a case report

et al. 2017

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BackgroundMesothelioma is a rare neoplasm which commonly develops in the pleura of people exposed to asbestos. Pericardial mesothelioma accounts for only 0.7 % of all malignant mesotheliomas and it usually presents with pericardial effusion, mimicking serositis. To date, there are approximately 200 cases of pericardial mesothelioma described in the medical literature, and little knowledge exists about the systemic manifestations of this pathology. The first and only described case of pericardial mesothelioma with autoimmune features dates back to 1984 and, in our case report, we describe the second. Case presentationWe report a case of a 45-year-old white woman whose pericardial mesothelioma was initially misdiagnosed as pericardial involvement of an autoimmune disease (systemic lupus erythematosus). After several relapses of pericardial effusion, a computed tomography scan and a biopsy with histological analysis were performed revealing neoplastic growth. ConclusionsWe describe a rare case of pericardial mesothelioma in a patient with a clinical presentation compatible with lupus serositis. Clinicians should consider malignant mesothelioma in the differential diagnosis of pericardial effusion, especially when it is recurrent and not clearly explained by other causes. Cytological samples should always be obtained and, if imaging tools are suggestive for solid processes, histological confirmation is mandatory.

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Section: Discussionmentioning

confidence: 99%

A second case of pericardial mesothelioma mimicking systemic lupus erythematosus in the literature in over 30 years: a case report

et al. 2017

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“…This has also been noted in other series. [4,6,8,12,15] Cancer, either overt or occult, [2,30] is quite common in patients with UEDVT (more than 40% of cases). [1][2][3][4][5][6][7][8]9,12] Independent of catheter placement, malignancy is an independent risk factor for VTE.…”

Section: Discussionmentioning

confidence: 99%

“…[28,31] Upper extremity deep vein thrombosis is sometimes a harbinger of occult cancer. [30] Ten patients with occult cancer were admitted with signs suggestive of SVC syndrome and/or UEDVT, and the malignancy was detected later. This also occurred in the series by Girolami et al [30] Patients with indwelling CVCs constitute a particularly high-risk population, especially those suffering from cancer and undergoing chemotherapy or those subjected to invasive hemodynamic monitoring, chronic parenteral nutrition, hemodialysis, or transvenous pacing.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of upper extremity deep venous thrombosis

Oymak¹

2012

Turk Gogus Kalp Dama

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Amaç: Bu çalışmada, üçüncü basamak bir sağlık kurumunda semptomatik üst ekstremite derin ven trombozlarının (ÜEDVT) prevalansı, özellikleri ve semptomatik pulmoner emboli (PE) ile birlikteliğinin belirlenmesi amaçlandı. So nuç: Üst ekstremite derin ven trombozu nadir görülen bir patoloji değildir. Etyolojisi sıklıkla multifaktöriyel olup, trombofili, SVK, PVY, kronik hastalıklar ve kansere sekonderdir. ÜEDVT'den kaynaklanan PE sık görülen bir komplikasyon olduğundan, risk faktörlü hastalar erken tanılanmalı ve tedavi edilmelidir.Anah tar söz cük ler: Aksiller ven; brakiyal ven; derin ven trombozu; pulmoner tromboemboli; subklaviyan ven; üst extremite derin ven thrombozu.Background:This study aims to determine the prevalence and characteristics of symptomatic upper extremity deep venous thrombosis (UEDVT) and its association with symptomatic pulmonary embolism (PE) in a tertiary care hospital.

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“…Thromboembolism may occur as part of a paraneoplastic syndrome or because of a decrease in anticoagulation factors. According to Ozkan et al, 3 mesothelioma cells and cell lines have been shown to secrete a pleiotropic cytokine, interleukin 6, which potentiates the production of platelets. However, the underlying mechanism of thrombosis in mesothelioma is still unknown.…”

Section: Discussionmentioning

confidence: 99%

Pleural mesothelioma: An unusual case diagnosed on pleural fluid cytology and immunocytochemistry

Arora

Aggarwal

Mathur

et al. 2009

Diagnostic Cytopathology

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Mesothelioma is a rare neoplasm with relationship to occupational and environmental exposure to asbestos. Its accurate and early diagnosis is often difficult. We present an unusual clinical presentation and diagnostic dilemma in a 30-year-male, who presented with neck pain and diffuse edema of left upper limb. The color Doppler ultrasound revealed venous thrombosis. The right supraclavicular lymph node biopsy revealed a poorly differentiated carcinoma. The patient had mild bilateral pleural effusion, the characteristic cytomorphological features of mesothelioma on fluid cytology were helpful in establishing the diagnosis.

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Antiphospholipid Syndrome Associated with Malignant Mesothelioma Presenting with Superior Vena Cava Thrombosis: A Case Report

Cited by 13 publications

References 18 publications

A second case of pericardial mesothelioma mimicking systemic lupus erythematosus in the literature in over 30 years: a case report

A second case of pericardial mesothelioma mimicking systemic lupus erythematosus in the literature in over 30 years: a case report

The prevalence of upper extremity deep venous thrombosis

Pleural mesothelioma: An unusual case diagnosed on pleural fluid cytology and immunocytochemistry

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