Antiparasitic properties of medicinal plants and other naturally occurring products

Tagboto, Senyo; Townson, Simon

doi:10.1016/s0065-308x(01)50032-9

Cited by 244 publications

(194 citation statements)

References 223 publications

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“…The medicinal actions of plants unique to particular plant species are consistent with the concept that the combination of secondary products in a particular plant is taxonomically distinct [1,2] . Plants remain a vital source of drugs, and nowadays much emphasis has been given to the development of novel drug used for the treatment and prevention of diseases [3][4][5] . Standardization is an essential measure of quality, purity and authenticity.…”

Section: Introductionmentioning

confidence: 99%

Chemical profiling of Elaeocarpus serratus L. by GC-MS

Geetha¹,

Rajeswari²,

Jayashree³

2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Introductionmentioning

confidence: 99%

Chemical profiling of Elaeocarpus serratus L. by GC-MS

Geetha¹,

Rajeswari²,

Jayashree³

2013

Asian Pacific Journal of Tropical Biomedicine

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“…Since the early 19th century, extracts from the papaya plant (Carica papaya) and many species of fig (Ficus species) have been used against ascarids, tapeworms, whipworms and hookworms by indigenous people, particularly in tropical countries (Berger and Asenjo, 1940). Recently, there has been a resurgence of interest in using plant extracts as anti-parasitic treatments (Hammond et al 1997 ;Tagboto and Townson, 2001 ;Waller et al 2001 ;Githiori et al 2004 ;Anthony et al 2005). Although there are numerous published reports detailing the efficacy of various plant extracts against parasitic nematodes (e.g.…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic action of plant cysteine proteinases against the rodent stomach nematode,Protospirura muricola,in vitroandin vivo

et al. 2006

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A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. Cysteine proteinases from the fruit and latex of plants, including papaya, pineapple and fig, were previously shown to have a rapid detrimental effect, in vitro, against the rodent gastrointestinal nematodes, Heligmosomoides polygyrus (which is found in the anterior small intestine) and Trichuris muris (which resides in the caecum). Proteinases in the crude latex of papaya also showed anthelmintic efficacy against both nematodes in vivo. In this paper, we describe the in vitro and in vivo effects of these plant extracts against the rodent nematode, Protospirura muricola, which is found in the stomach. As in earlier work, all the plant cysteine proteinases examined, with the exception of actinidain from the juice of kiwi fruit, caused rapid loss of motility and digestion of the cuticle, leading to death of the nematode in vitro. In vivo, in contrast to the efficacy against H. polygyrus and T. muris, papaya latex only showed efficacy against P. muricola adult female worms when the stomach acidity had been neutralized prior to administration of papaya latex. Therefore, collectively, our studies have demonstrated that, with the appropriate formulation, plant cysteine proteinases have efficacy against nematodes residing throughout the rodent gastrointestinal tract.

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“…It is estimated that two thirds of the world population still rely on traditional medical remedies, mainly plants, because of limited availability or affordability of pharmaceutical medicines. 13 Several well established human antiprotozoal drugs have their origins in nature, such as quinine, an alkaloid from Cinchona sp. (Rubiaceae) and artemisinin, a sesquiterpene lactone from Artemisia annua (Asteraceae) used to treat malaria, or emetine, an alkaloid from Cephaelis ipecacuanha (Rubiaceae) used to treat amoebiasis.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, these antiprotozoal plant-derived compounds have been used as leads to develop other semi-synthetic or synthetic drugs with better efficacy, safety or pharmacokinetic profiles. 13 The diversity of natural products with antiprotozoal activities has been illustrated in several reviews which cover molecules that are mainly active on the etiological agents of malaria, leishmaniasis or Chagas' disease. 14-19 This review includes the natural products that are active on the trypanosomes responsible for sleeping sickness and nagana.…”

Section: Introductionmentioning

confidence: 99%

Natural Products Active Against African Trypanosomes: A Step Towards New Drugs

et al. 2004

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This review covers compounds with activity on African trypanosomes (mainly Trypanosoma brucei subsp., T. congolense and T. vivax) isolated from natural sources and is organized according to the structure of the metabolites (alkaloids, phenolic derivatives, quinones, terpenes and other metabolites). The literature from the mid-1980s up to June 2003 is reviewed and 89 references are cited. Sara Hoet was born in

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Antiparasitic properties of medicinal plants and other naturally occurring products

Cited by 244 publications

References 223 publications

Chemical profiling of Elaeocarpus serratus L. by GC-MS

Chemical profiling of Elaeocarpus serratus L. by GC-MS

Anthelmintic action of plant cysteine proteinases against the rodent stomach nematode,Protospirura muricola,in vitroandin vivo

Natural Products Active Against African Trypanosomes: A Step Towards New Drugs

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