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Leaves and berries of Solanum nigrum are commonly used in South India for the treatment of gastric ulcers, gastritis and other gastric problems. The present study investigated the Solanum nigrum leaf and berry extracts for their protective effect on ethanol induced gastritis and aspirin induced gastric ulcers of pylorus ligated rats. Sucralfate and Ranitidine were used as standard Drugs. Oral administration of aqueous extract of leaf (80 mg/Kg and 250 mg/Kg respectively) and berry (50 mg/Kg) significantly reduced the concentration of Evans blue in both gastric contents and glandular tissue indicating decreased vascular permeability and mucosal damage with respect to that of control. The berry aqueous extract offered more protection against gastritis than the leaf extracts. Pretreatment with aqueous extracts of Leaf (250 mg/Kg) and berry (50 mg/Kg) significantly reduced the Ulcer Index. The results tend to confirm the popular use of the plant.

The present investigation was carried out to determine the possible bioactive compounds of ethanolic extract of Elaeocarpus serratus (Elaeocarpaceae) has been subjected to GC-MS analysis. Thirty compounds were detected from the plant E. serratus. The highest peak area percentage of 19.12% was obtained by n-propanol (RT=3.04min.) and lowest peak area percentage of 2.34% was obtained by 1-propylthio-3,3,3-trifluoropropyl acetate (RT=11.57min.). The presence of various bioactive compounds confirms many aliments by traditional practitioners. However, isolation of individual phytochemical constituents may proceed to find a novel drug.

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