Antioxidative Properties and Effect of Quercetin and Its Glycosylated Form (Rutin) on Acetylcholinesterase and Butyrylcholinesterase Activities

Ademosun, Ayokunle O.; Oboh, Ganiyu; Bello, Fatai; Ayeni, Peluola O.

doi:10.1177/2156587215610032

Cited by 125 publications

(82 citation statements)

References 26 publications

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“…Earlier study from our laboratory [43] re ported that caffeic acid and chlorogenic acid inhibited AChE and BChE activities in vitro, with caffeci acid producing the significantly higher inhibitory effects; nevertheless, their combination was reported to pro duce antagonistic effects on the enzymes' inhibition. Furthermore, Ademosun et al, [44] reported that quercetin had significantly higher cholinesterase inhibitory effects than its glycosylated form (rutin). Therefore, in this study, interactions between the constituent phenolic phytochemicals in the extracts could also contribute significantly to the observed enzyme inhibitory effects.…”

Section: Resultsmentioning

confidence: 98%

In vitro neuroprotective properties of some commonly consumed green leafy vegetables in Southern Nigeria

et al. 2016

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Green leafy vegetable is one of the major cuisines in Southern Nigeria and they are not only consumed for their palatability, but also for their nutritional and medicinal properties as reported in folklore. Notable among them are afang (Gnetum africanum), editan (Lasianthera africana) and utazi (Gongronema latifolium). In this study, we investigated the effect of aqueous extracts from afang, editan and utazi leaves on cholinesterases [acetylcho linesterase (AChE) and butyrylcholinesterase (BChE)] and monoamine oxidase (MAO) activities. Fe 2+ chelating abilities were also determined as an assessment of their neuroprotective potentials in vitro. We also assayed for their total phenol contents while the constituent phenolics were characterized using high performance liquid chromatography coupled with diode array detector (HPLC-DAD). The results revealed that the extracts inhibited AChE, BChE and MAO activities and also chelated Fe 2+ in concentration dependent manner. The HPLC-DAD char acterization showed that gallic, caffeic and ellagic acids and rutin were the dominant phenolic compounds in the extracts; nevertheless, utazi had the highest distribution of identified phenolics while afang had the least. The ability of the aqueous extracts of the vegetables to inhibit key enzymes (AChE, BChE and MAO) relevant to neu rodegeneration, as well chelate metal ion could help suggest their possible neuroprotective properties. These vegetables could be use as dietary intervention in the management of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.

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Section: Resultsmentioning

confidence: 98%

In vitro neuroprotective properties of some commonly consumed green leafy vegetables in Southern Nigeria

et al. 2016

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“…From the IC 50 values listed in Table , SA displayed higher inhibitory effect against both cholinesterases than QU. The flavonoid content of SA and the presence of quercetin in conjunction with chlorogenic and caffeic acids, which have been demonstrated to be potent inhibitor of cholinesterases (Ademosun et al, ; Oboh, Agunloye, Akinyemi, Ademiluyi, & Adefegha, ; Sriraksa et al, ), could have (but not completely) responsible for this effects. Although, this effect could be considered lower than that of the synthetic inhibitors, such as galantamine (IC 50 for AChE = 0.14 μg/mL) or huperzine A (IC 50 = 10 −4 μM) (Mukherjee, Kumar, Mal, & Houghton, ; Wszelaki, Kuciun, & Kiss, ), but the adverse effects exhibited by these synthetic drugs/inhibitors may not be experience using plants or plant‐based inhibitors such as the plants in use (Ademosun et al, ; Chaiyana & Okonogi, ; de Paula et al, )…”

Section: Resultsmentioning

confidence: 99%

“…The research on herbal plants are on the increase, focusing on the preparation of alternative pharmaceutical ingredients for the management of several human ailments (Ceylan et al, ; Hirasa & Takemasa, ). The interest in finding natural cholinesterases (ChEs) inhibitors for the management of cognitive/mental disorders is on the increase as studies have shown that polyphenolic compounds such as quercetin, rutin among others could of health benefits (Ademosun, Oboh, Bello, & Ayeni, ; Gironés‐Vilaplana et al, ; Khan et al, ; Nwanna et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, these synthetic inhibitors adversely exhibited ill‐effect such as nausea, hepatotoxicity among others, and low therapeutic effect toward memory improvement in mild dementia and cannot stop the process of neurodegeneration (Akinyemi et al, ; Chaiyana & Okonogi, ; de Paula et al, ; Schneider, ). Therefore, co‐inhibitors of AChE and BChE activities for holistic and effective treatment/management of AD is desirable, and compound from natural sources including phenolic compound, with ability to prevent oxidative stress, another culprit in the pathophysiology of AD have been proved effective (Ademosun et al, ; Oboh et al, ). In view of the aforementioned, this study sought to investigate and compare the AChE and BChE inhibitory, and antioxidative capacity of Senecio abyssinicus (SA) and Quassia undulata (QU).…”

Section: Introductionmentioning

confidence: 99%

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Anticholinesterase activity and phenolic profile of two medicinal plants (Quassia undulataandSenecio abyssinicus) used in managing cognitive dysfunction in Nigeria

et al. 2018

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Quassia undulata (QU) and Senecio abyssinicus (SA) leaves are known in folklore in the management of cognitive disorder in Nigeria. However, there is dearth of information about their mechanism of actions. In this study, the effect of QU and SA aqueous extracts on acetylcholinesterase (AChE) and butrylcholinesteras (BChE) activities were determined as well as their antioxidant capacity and phenolic constituents. The result showed that both extracts inhibited AChE and BChE activities and also exhibited antioxidant effect, however, extract from SA had the highest effect compared to that of QU. HPLC analysis revealed the presence of gallic, ellagic, caffeic, quercetin, rutin, and catechin. The inhibition of AChE and BChE activities, and antioxidant capacity of QU and SA could be among the mechanism of actions regarding their use in folklore for the management of cognitive dysfunction. These could therefore be linked to their richness in phenolic compounds, as SA extract exhibited higher effects. Practical applicationsMany plants have been used traditionally in the treatment of various disorders owing to their bioactivity. The outcome of this research provides biochemical information to the folkloric use of Quassia undulate and Senecio abyssinicus in the management of neurodegenerative disorder, and also to the pharmacologist with an option to synthesize drugs with little or no side effects. K E Y W O R D S anticholinesterase, antioxidant, medicinal plants, neurodegeneration, Quassia undulata, Senecio abyssinicus

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“…Quercetin (0.1‐0.4 mmol/L) has also been reported to significantly inhibit AChE (IC 50 = 0.18 mmol/L) and BChE (IC 50 = 0.203 mmol/L) along with a strong inhibition of Fe (2+) ‐induced lipid peroxidation and radical scavenging abilities in rats’ brain homogenates . The inhibition of cholinesterases (ChEs) and antioxidative properties are possible mechanisms of action of quercetin for the management of oxidative stress‐induced neurodegeneration.…”

Section: Quercetinmentioning

confidence: 99%

Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer’s disease

2018

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Alzheimer's disease (AD) is a progressive irreversible neurodegenerative disorder characterized by excessive deposition of β-amyloid (Aβ) oligomers, and neurofibrillary tangles (NFTs), comprising of hyperphosphorylated tau proteins. The cholinergic system has been suggested as the earliest and most affected molecular mechanism that describes AD pathophysiology. Moreover, cholinesterase inhibitors (ChEIs) are the potential class of drugs that can amplify cholinergic activity to improve cognition and global performance and reduce psychiatric and behavioral disturbances. Approximately, 60%-80% of all cases of dementia in the world are patients with AD. In view of the continuous rise of this disease especially in the aged population, there is a dire need to come up with a novel compound and/or mixture that could work against this devastating disease. In this regard, the best is to rely on natural compounds rather than synthetic ones, because natural compounds are easily available, cost-effective, and comparatively less toxic. To serve this purpose, lately, scientific community has started exploring the possibility of using different polyphenols either solitary or in combination that can serve as therapeutics against AD. In the current article, we have summarized the role of various polyphenols, namely quercetin, resveratrol, curcumin, gallocatechins, cinnamic acid, caffeine, and caffeic acid as an inhibitor of cholinesterase for the treatment of AD. We have also tried to uncover the mechanistic insight on the action of these polyphenols against AD pathogenicity.

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Antioxidative Properties and Effect of Quercetin and Its Glycosylated Form (Rutin) on Acetylcholinesterase and Butyrylcholinesterase Activities

Cited by 125 publications

References 26 publications

In vitro neuroprotective properties of some commonly consumed green leafy vegetables in Southern Nigeria

In vitro neuroprotective properties of some commonly consumed green leafy vegetables in Southern Nigeria

Anticholinesterase activity and phenolic profile of two medicinal plants (Quassia undulataandSenecio abyssinicus) used in managing cognitive dysfunction in Nigeria

Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer’s disease

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