Antioxidative Phenolic Glycosides from Sage (<i>Salvia </i><i>officinalis</i>)

Wang, Mingfu; Yu, Shanshan; Li, Jiangang; Zhu, Nanqun; Rangarajan, Meera; LaVoie, Edmond J.; Ho, Chi Tang

doi:10.1021/np980436g

Cited by 85 publications

(27 citation statements)

References 13 publications

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“…An aqueous methanol extract of S. officinalis dose-dependently inhibited lipid peroxidation (Hohmann et al, 1999). Several antioxidant compounds have been identified in S. officinalis, including caffeic acid, carnosic acid, carnosol, rosmarinic acid (Cuvelier et al, 1996;Wang et al, 2000), salvianolic acids I, K and L and various other phenolic compounds Foo, 2001, 2001b;Wang et al, 1999). Weak antioxidant effects were also shown to be present in an ethanol extract of S. lavandulaefolia (when compared with the standard antioxidant 10 mM propyl gallate), and both the water-soluble and chloroform-soluble fractions of this extract gave similar activity (Perry et al, 2001).…”

Section: Cholinesterase Inhibition In Vitromentioning

confidence: 99%

Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

Howes

Perry

Houghton

2003

Phytotherapy Research

352

241

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In traditional practices of medicine, numerous plants have been used to treat cognitive disorders, including neurodegenerative diseases such as Alzheimer's disease (AD) and other memory related disorders. An ethnopharmacological approach has provided leads to identifying potential new drugs from plant sources, including those for memory disorders. There are numerous drugs available in Western medicine that have been directly isolated from plants, or are derived from templates of compounds from plant sources. For example, some alkaloids from plant sources have been investigated for their potential in AD therapy, and are now in clinical use (e.g. galantamine from Galanthus nivalis L. is used in the United Kingdom). Various other plant species have shown favourable effects in AD, or pharmacological activities indicating the potential for use in AD therapy. This article reviews some of the plants and their active constituents that have been used in traditional medicine, including Ayurvedic, Chinese, European and Japanese medicine, for their reputed cognitive-enhancing and antidementia effects. Plants and their constituents with pharmacological activities that may be relevant to the treatment of cognitive disorders, including enhancement of cholinergic function in the central nervous system, anti-cholinesterase (anti-ChE), antiinflammatory, antioxidant and oestrogenic effects, are discussed.

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Section: Cholinesterase Inhibition In Vitromentioning

confidence: 99%

Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

Howes

Perry

Houghton

2003

Phytotherapy Research

352

241

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“…Such antioxidatively active constituents as carnosic acid, carnosol, rozmarinic acid, rosmanol, epirosmanol and isorosmanol are the main compounds identified in sage and rosemary [6][7][8][9]. Some important phenolic glycosides have also been reported [10].…”

Section: Introductionmentioning

confidence: 99%

Rapid screening of antioxidant activity of sage (Salvia officinalis L.) extracts obtained by supercritical carbon dioxide at different extraction conditions

Daukšas

Venskutonis²,

Povilaitytė

et al. 2001

Nahrung

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Sage herb (Salvia officinalis L.) was extracted at supercritical fluid extraction (SFE) conditions with carbon dioxide at different parameters and the extracts tested on their antioxidant activity (AA). SFE of sage herb at 35 MPa pressure was found to be an effective method to obtain pure extracts. The yields of the extracts were substantially increased by using 1% of entrainer solvent ethanol. The fractionation of sage extract was a complex procedure in terms of extract distribution between separators operating at various pressure and temperature conditions. It was also proved by testing the AA of the extracts in rapeseed oil. The effect of the extracts on the rapeseed oil weight gain varied in a wide range (from 'very low' to 'high') depending on the fractionation conditions. Preliminary results showed that to obtain more effective antioxidant fractions separation steps should be started at 10 MPa lower pressure than that used for the extraction.

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“…Flavonoids are widely existed in the plants and various biological functions in previous studies (Kumar & Pandey, 2013;Lopes, Schulman, & Hermes-Lima, 1999). These studies suggest that flavonoids have various pharmacological properties such as anti-cancer, antioxidant, antihypertensive, antiatherosclerotic, and anti-inflammatory properties (Lee et al, 2012;Ray et al, 1999;Wang et al, 1999). Of these biological properties, the anti-inflammatory effects F I G U R E 5 Inhibitory effects of Antirrhinum majus extract (AME) on lipopolysaccharide (LPS)-stimulated pro-inflammatory cytokine expression in RAW 264.7 cells.…”

Section: Inhibitory Effects Of Ame On Pro-inflammatory Cytokine Promentioning

confidence: 96%

Anti‐inflammatory effect ofAntirrhinum majusextract in lipopolysaccharide‐stimulated RAW 264.7 macrophages

Jang

Hwang

et al. 2020

Food Science & Nutrition

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Antirrhinum majus (AM) has attracted attention as a rich source of phytochemicals, which are beneficial for human health. However, the anti‐inflammatory effects of AM have not been studied scientifically. Therefore, we investigated the antioxidative properties and anti‐inflammatory effects of AM extract (AME) in lipopolysaccharide (LPS)‐stimulated RAW 264.7 macrophages. AME showed high radical‐scavenging ability. Viability of RAW 264.7 cells was not significantly altered by AME at the concentrations of 0–300 µg/ml. LPS‐induced nitric oxide (NO) production was decreased by treatment with 0–300 µg/ml AME in a concentration‐dependent manner. AME pretreatment significantly inhibited the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2) in a concentration‐dependent manner. AME also considerably inhibited the mRNA and protein expression of inflammatory cytokines, such as tumor necrosis factor‐a (TNF‐α), interleukin‐1 β (IL‐1β), and interleukin‐6 (IL‐6). These findings provide a foundation for further studies and use of AM in nutraceuticals.

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Antioxidative Phenolic Glycosides from Sage (Salvia officinalis)

Cited by 85 publications

References 13 publications

Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

Rapid screening of antioxidant activity of sage (Salvia officinalis L.) extracts obtained by supercritical carbon dioxide at different extraction conditions

Anti‐inflammatory effect ofAntirrhinum majusextract in lipopolysaccharide‐stimulated RAW 264.7 macrophages

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