Antioxidative Effects of Red Ginseng Saponins on Paraquat-induced Oxidative Stress

김동조,; 성금수,; 김동원,; 고성룡,; 장재철,

doi:10.5142/jgr.2004.28.1.005

Cited by 19 publications

(2 citation statements)

References 11 publications

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“…Considering this, it can be noted that RG and FRG are created by the steaming and maturation of ginseng for ‘FRG manufacturer’. RG ethanol extracts made from the steaming and maturation of water ginseng have greater anti-oxidant activity [39], and red ginseng’s ginsenosides Rb 1 and Rg 1 have lipid oxidant suppression and antioxidant activities [19]. Furthermore, red ginseng’s ginsenoside Rh 2 can significantly increase antioxidant enzymatic activity, thus showing antioxidant effects [26,40].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Effects of Fermented Red Ginseng Extracts in Streptozotocin-Induced Diabetic Rats

Kim¹,

Lee²,

Chae³

et al. 2011

Journal of Ginseng Research

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The antioxidant activities of fermented red ginseng (FRG) were investigated in vitro and in vivo. The contents of total polyphenol and total flavonoid in FRG extracts were 17.01±2.00 μg/mg and 18.42±3.97 μg/mg, respectively. These extracts were capable of directly scavenging α, α-diphenyl-picrylhydrazyl free radicals. The antioxidative effects of the FRG extracts in streptozotocin (STZ)-induced diabetic rats were also investigated. The activities of plasma alanine transaminase, aspartate transaminase, and γ-glutamyltransferase were significantly decreased by extract administration as compared to an STZ control group. Hepatic glutathione content depleted by STZ treatment was significantly increased by treatment of the FRG extracts, but the elevation of lipid peroxide content induced by STZ was significantly decreased by the extracts. Activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase decreased after STZ-treatment were recovered by the treatment of the FRG extracts. These results indicate that FRG extracts have antioxidative effets in STZ-induced diabetic rats.

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Section: Resultsmentioning

confidence: 99%

Antioxidant Effects of Fermented Red Ginseng Extracts in Streptozotocin-Induced Diabetic Rats

Kim¹,

Lee²,

Chae³

et al. 2011

Journal of Ginseng Research

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“…Numerous studies have suggested that ginsenosides protect cells by preventing oxidative damage, thereby preventing the occurrence and progression of diseases ( Kang et al, 2013 ; Ong et al, 2015 ). Possible mechanisms mentioned in previous studies include their ability to inhibit oxidative damage by inhibiting malondialdehyde (MDA) formation, reducing lipid peroxidation, and regulating the activity of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and other antioxidant factors ( Kim et al, 2004 ). In addition, it has also been suggested that modulation of oxidative stress-related oxidative signaling pathways, such as the Keap1/Nrf2/ARE, PI3K/Akt, and Wnt/β-catenin, and nuclear factor-k-gene binding (NF-κB) signaling pathways, is also an important way in which ginsenosides exert antioxidant damage ( Li et al, 2016 ; Chen et al, 2019 ; Hagar et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Anticancer therapeutic effect of ginsenosides through mediating reactive oxygen species

Li¹,

Cao²,

Sun³

et al. 2023

Front. Pharmacol.

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Dysregulation of reactive oxygen species (ROS) production and ROS-regulated pathways in cancer cells leads to abnormal accumulation of reactive oxygen species, displaying a double-edged role in cancer progression, either supporting transformation/proliferation and stimulating tumorigenesis or inducing cell death. Cancer cells can accommodate reactive oxygen species by regulating them at levels that allow the activation of pro-cancer signaling pathways without inducing cell death via modulation of the antioxidant defense system. Therefore, targeting reactive oxygen species is a promising approach for cancer treatment. Ginsenosides, their derivatives, and related drug carriers are well-positioned to modulate multiple signaling pathways by regulating oxidative stress-mediated cellular and molecular targets to induce apoptosis; regulate cell cycle arrest and autophagy, invasion, and metastasis; and enhance the sensitivity of drug-resistant cells to chemotherapeutic agents of different cancers depending on the type, level, and source of reactive oxygen species, and the type and stage of the cancer. Our review focuses on the pro- and anticancer effects of reactive oxygen species, and summarizes the mechanisms and recent advances in different ginsenosides that bring about anticancer effects by targeting reactive oxygen species, providing new ideas for designing further anticancer studies or conducting more preclinical and clinical studies.

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Enhancement of the cytotoxicities and antioxidative activities of white ginseng extract by hydrolysis under mild acidic conditions

Chang

Park

Jee

et al. 2013

Food Sci Biotechnol

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Antioxidative Effects of Red Ginseng Saponins on Paraquat-induced Oxidative Stress

Cited by 19 publications

References 11 publications

Antioxidant Effects of Fermented Red Ginseng Extracts in Streptozotocin-Induced Diabetic Rats

Antioxidant Effects of Fermented Red Ginseng Extracts in Streptozotocin-Induced Diabetic Rats

Anticancer therapeutic effect of ginsenosides through mediating reactive oxygen species

Enhancement of the cytotoxicities and antioxidative activities of white ginseng extract by hydrolysis under mild acidic conditions

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