Antioxidative effect of melatonin on cryopreserved ovarian tissue in mice

Liu, Xiao Chao; Sun, Tie; Li, Hui Ying; Na, Li; Wei, Meng; Chen, Zhi Hong; Cheng, Lu; Yang, Song

doi:10.1016/j.cryobiol.2020.07.010

Cited by 16 publications

(12 citation statements)

References 24 publications

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“…ROS production has been reported to affect the vitrification process, causing cell dysfunction and a decline in oocyte survival rate by the activation of apoptotic cell death [ 80 ]. MLT has been used in the cryopreservation of OT from adolescent SPF KM mice to counteract the adverse effects of oxidation on follicles [ 81 ]. Treated animals presented a well-preserved follicular morphology, with increased dimensions compared to the untreated ones, and a dose–response effect of MLT was observed when there was a decrease in apoptotic follicles, suggesting that this hormone may also play a role in the development of polycystic ovaries.…”

Section: The Role Of Melatonin (Mlt) In Cytoprotection and Cryopreser...mentioning

confidence: 99%

Natural Cryoprotective and Cytoprotective Agents in Cryopreservation: A Focus on Melatonin

et al. 2022

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Cryoprotective and cytoprotective agents (Cytoprotective Agents) are fundamental components of the cryopreservation process. This review presents the essentials of the cryopreservation process by examining its drawbacks and the role of cytoprotective agents in protecting cell physiology. Natural cryoprotective and cytoprotective agents, such as antifreeze proteins, sugars and natural deep eutectic systems, have been compared with synthetic ones, addressing their mechanisms of action and efficacy of protection. The final part of this article focuses melatonin, a hormonal substance with antioxidant properties, and its emerging role as a cytoprotective agent for somatic cells and gametes, including ovarian tissue, spermatozoa and spermatogonial stem cells.

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Section: The Role Of Melatonin (Mlt) In Cytoprotection and Cryopreser...mentioning

confidence: 99%

Natural Cryoprotective and Cytoprotective Agents in Cryopreservation: A Focus on Melatonin

et al. 2022

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“…However, in elderly individuals, increased ROS production outpaces the antioxidative system's capacity to safeguard. Endogenous antioxidant enzymes (including SOD, CAT, and GSH‐Px) act as the body's natural resistance to the oxidative stress defense system (Liu et al, 2020 ). Following 6‐OHDA treatment, antioxidant enzyme activity in the cell significantly decreases.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of a novel peptide from Lignosus rhinocerotis against 6‐hydroxydopamine‐induced apoptosis in PC12 cells by inhibiting NF‐κB activation

Luo

Phan

et al. 2022

Food Science & Nutrition

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According to previous studies, oxidative stress is a leading cause of dopaminergic neuron death and may contribute to the pathogenesis of Parkinson's disease (PD). In the current study, we used chromatography of gel filtration to identify a novel peptide ( Lignosus rhinocerotis peptide [LRP]) from the sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden. Its neuroprotective effect was evaluated using an in vitro PD model constructed by 6‐hydroxydopamine (6‐OHDA)‐stimulated to apoptosis in PC12 cells. The molecular weight of LRP is determined as 1532 Da and the secondary structure is irregular. The simple amino acid sequence of LRP is Thr‐Leu‐Ala‐Pro‐Thr‐Phe‐Leu‐Ser‐Ser‐Leu‐Gly‐Pro‐Cys‐Leu‐Leu. Notably, LRP has the ability to significantly boost the viability of PC12 cells after exposure to 6‐OHDA, as well as enhance the cellular activity of antioxidative enzymes like superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH‐Px). LRP also lowers the level of malondialdehyde (MDA), decreases the activation performance of Caspase‐3, and reduces 6‐OHDA‐induced apoptosis via inhibition of nuclear factor‐kappa B (NF‐κB) activation. These data indicate that LRP may have the potential to act as a neuroprotective agent.

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“…Additionally, MT plays a central role in the reproductive system by upregulating LH receptor mRNA to suppress gonadotropin-releasing hormone (GnRH) and GnRH receptor expression as well [56]. As for the resource, MT in the ovary can be derived from sys-temic blood circulation or synthesized by granulosa cells, including the cumulus granulosa cells and oocytes [57][58][59][60]. MT1 and melatonin receptor type 2 (MT2) mRNAs can be detected in human granulosa cells and luteal cells [52].…”

Section: There Is a Strong Connection Between Melatonin (Mt) And Poimentioning

confidence: 99%

Therapeutic Effect of Melatonin in Premature Ovarian Insufficiency: Hippo Pathway Is Involved

Sun

Yang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Objective. Premature ovarian insufficiency (POI) is a female reproductive disorder of unknown etiology with no definite pathogenesis. Melatonin (MT) is an endogenous hormone synthesized mainly by pineal cells and has strong endogenous effects in regulating ovarian function. To systematically explore the pharmacological mechanism of MT on POI therapy, a literature review approach was conducted at the signaling pathways level. Methods. Relevant literatures were searched and downloaded from databases, including PubMed and China National Knowledge Infrastructure, using the keywords “premature ovarian insufficiency,” “Hippo signaling pathways,” and “melatonin.” The search criteria were from 2010 to 2022. Text mining was also performed. Results. MT is involved in the regulation of Hippo signaling pathway in a variety of modes and has been correlated with ovarian function. Conclusions. The purpose of this review is to summarize the research progress of Hippo signaling pathways and significance of MT in POI, the potential crosstalk between MT and Hippo signaling pathways, and the prospective therapy.

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Antioxidative effect of melatonin on cryopreserved ovarian tissue in mice

Cited by 16 publications

References 24 publications

Natural Cryoprotective and Cytoprotective Agents in Cryopreservation: A Focus on Melatonin

Natural Cryoprotective and Cytoprotective Agents in Cryopreservation: A Focus on Melatonin

Neuroprotective effects of a novel peptide from Lignosus rhinocerotis against 6‐hydroxydopamine‐induced apoptosis in PC12 cells by inhibiting NF‐κB activation

Therapeutic Effect of Melatonin in Premature Ovarian Insufficiency: Hippo Pathway Is Involved

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