Antioxidative and renoprotective effects of residue polysaccharides from Flammulina velutipes

Lin, Lin; Cui, Fangyuan; Zhang, Jianjun; Gao, Xia; Zhou, Meifang; Xu, Nuo; Zhao, Huajie; Ling, Min; Zhang, Chen

doi:10.1016/j.carbpol.2016.03.071

Cited by 87 publications

(63 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The serum levels of BUN and CREA can be interpreted as indices of renal dysfunction [21, 22]. Histopathological changes and the renal organ index are indicators used to evaluate the toxicity of Pb in rats [23].…”

Section: Discussionmentioning

confidence: 99%

GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3β in rat kidney

et al. 2017

View full text Add to dashboard Cite

Lead (Pb) is a global environmental health hazard that leads to nephrotoxicity. However, the effective treatment of Pb-induced nephrotoxicity remains elusive. Grape seed procyanidin extract (GSPE) has beneficial properties for multiple biological functions. Therefore, the present study investigated whether GSPE reduced Pb-induced nephrotoxicity as well as the protective mechanism of GSPE in a well-established 35-day Pb induced nephrotoxicity rat model. The results showed that GSPE normalized Pb-induced oxidative stress, histological damage, inflammatory, apoptosis, and changes of miR153 and glycogen synthase kinase 3β (GSK-3β) levels in rat kidney. Moreover, GSPE enhanced the induction of phase II detoxifying enzymes (heme oxygenase-1 and NAD(P)H quinone oxidoreductase 1) by increasing nuclear factor-erythroid-2-related factor 2 (Nrf2) expression. This study identifies for the first time that Pb-induced oxidative stress in rat kidney is attenuated by GSPE treatment via activating Nrf2 signaling pathway and suppressing miR153 and GSK-3β. Nrf2 signaling provides a new therapeutic target for renal injury induced by Pb, and GSPE could be a potential natural agent to protect against Pb-induced nephrotoxicity.

show abstract

Section: Discussionmentioning

confidence: 99%

GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3β in rat kidney

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Polysaccharides isolated from Auricularia auricula significantly promote glucose metabolism and reduced blood glucose levels and protect against DN by regulating blood urea nitrogen, creatinine, urine protein and inflammation-related factors (Hu et al, 2017). Residue polysaccharides from Flammulina velutipes, which can be used to treat DN, protect against OS by removing reactive oxygen species (ROS) and lowering the content of malondialdehyde (MDA) in the kidney (Lin et al, 2016). Available data also suggest that proteoglycans extracted from the fruit body of G. lucidum protects kidney function through antioxidant activities (Pan et al, 2014).…”

Section: Chronic Complicationsmentioning

confidence: 99%

“…En-RPS contains Ara (8.1%), Xyl (9.7%), Gal (71.7%), and Glu (10.5%). The three polysaccharides, particularly 800 mg/kg En-RPS, exhibits renoprotective effects via antioxidation (Lin et al, 2016). Three P. djamor mycelium zinc polysaccharides (MZPS), including acidic-MZPS, alkalic-MZPS and enzymatic-MZPS, show protective effects on the kidney and liver in STZ-induced diabetic mice by reducing OS (Zhang et al, 2015).…”

Section: Effects Of Mushroom Polysaccharides On Hyperglycemia and Adjmentioning

confidence: 99%

Adjuvant Therapy With Mushroom Polysaccharides for Diabetic Complications

Jiang

Meng

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

Background: Diabetic complications seriously endanger the health of most diabetic patients around the world. Most chemical hypoglycemic agents have adverse effects and are unable to improve the progression of diabetic complications. In recent years, a number of medicinal herbs have become increasingly popular for the treatment of diabetic complications due to their relative safety. Polysaccharides extracted from medicinal herbs with multiple pharmacological activities and low toxicity have been reported to be useful in the treatment of diabetic complications. Methods: Primary studies with keywords including polysaccharide and diabetic complications were retrieved from the Web of Science and NCBI databases and were read and analyzed. Results: Mushroom polysaccharides were proven to have positive effects on diabetic complications. Conclusions: We studied the effects of mushroom polysaccharides on hyperglycemia and as adjuvant therapies for diabetic complications and summarized the applications and limitations of mushroom polysaccharides to better understand their application for the treatment of diabetic complications.

show abstract

“…Previous studies indicated that the polysaccharides, oligosaccharides and extracts prepared from fruiting FV body showed strong antioxidant activities [42][43][44]. For instance, the Flammulina velutipes polysaccharide (FVP) was reported to have potential effects in increasing the activities of SOD, CAT and GSH-Px, and in reducing the contents of MDA in kidney of humans [45]. The FVP was also reported to be able to increase the proliferation of macrophage [46], promote the secretion of interleukin-1β, interleukin-6 and tumor necrosis factor-α secreted by macrophages and stimulate the lymphocyte proliferation [43].…”

Section: Fecal Short Chain Fatty Acids Production and Serumal Indicesmentioning

confidence: 99%

Dietary Supplementation with Flammulina velutipes Stem Waste on Growth Performance, Fecal Short Chain Fatty Acids and Serum Profile in Weaned Piglets

Liu

Zhao

Zhang

et al. 2020

Animals

View full text Add to dashboard Cite

This study was conducted to evaluate the effects of dietary FVS supplementation on growth performance, nutrient digestibility, biochemical profile of serum and fecal short chain fatty acids (SCFAs) production in weaned piglets. In Exp.1, 150 weaned pigs (initial body weight: 6.89 ± 1.17 kg) were allotted to five dietary treatments. The treatment diets included a basal diet and four experimental diets supplemented with 2.5%, 5.0%, 7.5% and 10.0% FVS respectively. The animal trial lasted for 28 days. In Exp.2, 72 piglets (initial body weight: 8.20 ± 1.67 kg) were allotted to three dietary treatments. The treatment diets included a basal diet and two experimental diets supplemented with 1.5% and 3.0% FVS, respectively. The animal trial lasted for 56 days. The results showed that pigs fed dietary FVS with 3% or lower inclusion levels had no significant difference (p > 0.10) on growth performance compared with pigs fed the control diet during day 1–28 and day 1–56. Dietary FVS supplementation decreased the apparent total tract digestibility (ATTD) of nutrients on day 28, day 35 and day 56, but no significant changes (p > 0.05) of nutrient digestibility were observed on day 14. Although piglets fed diets with higher levels of FVS showed impaired growth performance and ATTD of nutrients, dietary FVS supplementation improved the fecal SCFA production, antioxidant capacity, interleukin-2 and growth hormone levels in serum, and reduced the harmful low-density lipoprotein levels in serum on day 56. In conclusion, as a promising alternative fibrous ingredient, FVS could be supplemented in diets of weaned piglets with a proportion under 3%.

show abstract

Antioxidative and renoprotective effects of residue polysaccharides from Flammulina velutipes

Cited by 87 publications

References 36 publications

GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3β in rat kidney

GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3β in rat kidney

Adjuvant Therapy With Mushroom Polysaccharides for Diabetic Complications

Dietary Supplementation with Flammulina velutipes Stem Waste on Growth Performance, Fecal Short Chain Fatty Acids and Serum Profile in Weaned Piglets

Contact Info

Product

Resources

About