Antioxidative and hepatoprotective effects of enzymatic and acidic-hydrolysis of Pleurotus geesteranus mycelium polysaccharides on alcoholic liver diseases

Song, Xinling; Zhong-hai, Liu; Zhang, Jianjun; Zhang, Chen; Dong, Yuhan; Ren, Zhenzhen; Gao, Zheng; Ling, Min; Zhao, Huajie

doi:10.1016/j.carbpol.2018.08.058

Cited by 33 publications

(24 citation statements)

References 47 publications

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“…These findings show that TOP-2 administration could down-regulate the elevated AST and ALT activities back to normal, indicating that TOP-2 had the potential to stabilize the plasma membrane, thereby protecting the structural integrity of hepatocytes from alcohol exposure [30]. These consequences are consistent with the previous reports [31,32].…”

Section: Resultssupporting

confidence: 91%

Optimization of Ultrasonic-Microwave Assisted Extraction and Hepatoprotective Activities of Polysaccharides from Trametes orientalis

et al. 2019

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Ultrasonic-microwave assisted extraction (UMAE) of Trametes orientalis polysaccharides was optimized by response surface methodology. Hepatoprotective effects of a purified T. orientalis polysaccharide (TOP-2) were evaluated by alcohol-induced liver injury model mice. The optimal UMAE parameters were indicated as below: ratio of water to raw material 28 mL/g, microwave power 114 W, extraction time 11 min. The polysaccharides yield was 7.52 ± 0.12%, which was well consistent with the predicted value of 7.54%. Pre-treatment with TOP-2 effectively increased the liver index and spleen index in alcohol-treated mice. The elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels of mice after alcohol exposure were inhibited by TOP-2 administration. The liver tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) levels have decreased significantly as a result of alcohol exposure, while pre-treatment with TOP-2 could mitigate these consequences. Furthermore, pre-treatment with TOP-2 could efficiently boost the superoxidase dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities, and observably constrain the malondialdehyde (MDA) level. The findings suggest that TOP-2 might be useful for alleviating the alcohol-induced hepatotoxicity via its antioxidant and anti-inflammatory potential.

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Section: Resultssupporting

confidence: 91%

Optimization of Ultrasonic-Microwave Assisted Extraction and Hepatoprotective Activities of Polysaccharides from Trametes orientalis

et al. 2019

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“…Meantime, Chen et al have showed that low-Mw polysaccharides possess superior biological activity, compared with high-Mw polysaccharides [34]. Meng et al and Song et al had reported that polysaccharides with α - and β -configurations possessed strong antioxidant, immunostimulatory, and hepatoprotective activities [29, 41]. These conclusions supported that ADES1 containing Glc with α - and β -configurations had antioxidant and other biological activities.…”

Section: Resultsmentioning

confidence: 88%

Antioxidant and Hypolipidemic Activities of Acid-Depolymerised Exopolysaccharides by Termitomyces albuminosus

Zhao

Wang

Liu

et al. 2019

Oxidative Medicine and Cellular Longevity

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The acid-depolymerised exopolysaccharides (ADES) of Termitomyces albuminosus were obtained, and the major fraction of ADES1 was isolated and purified by DEAE-52 cellulose anion-exchange column chromatography. Physicochemical characterizations showed that ADES1 was an α- and a β-configuration with the molecular weight of 2.43 kDa, containing (1→3, 4)-linked-Glcp, (1→4)-linked-D-Glcp, (1→3)-linked-D-Xylp, (1→4)-linked-D-Manp, T-Glcp, (1→6)-linked-D-Galp, and (1→4)-linked-L-Arap. The in vivo assays showed that ADES1 could reduce lipid levels in the serum and liver, decrease serum enzyme activities, and improve antioxidant enzyme activities and p-AMPKα expressions in hyperlipidemic mice, which were also confirmed by histopathological observations. These data indicated that ADES1 might be considered as a novel substance to treat and prevent hyperlipidemia and as a hepatoprotective agent.

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“…In another study, enzymatic and acidic hydrolysates of polysaccharides isolated from Pleurotus geesteranus mycelium were also effective in protecting mouse liver against injury by ethanol, but the efficiency was not obvious unless the dose was increased to 200 mg/kg-b.w. and treatment course was extended to 25 days (Song et al, 2018). In our study, just seven days of Ah-MVPS treatment to mice by oral gavage at a dose of 62.5 mg/kg-b.w.…”

Section: Discussionmentioning

confidence: 95%

“…Therefore, we chose a very representative oxidative stress injury model induced by H 2 O 2 and/or ethanol to further evaluate the protective activities of Ah-MVPS in cellular experiments in association with comparing with the results of bifendatatum as the positive drug. It has an obvious antioxidant effect, inhibiting hepatic lipid peroxidation by stabilizing the hepatocyte membrane, alleviating the structural damage of hepatic tissue, and reducing the ALT and AST leakages arising due to various pathogenic damages, such as CCl 4 and ethanol intoxication of hepatocytes (Liu et al, 2016;Jing et al, 2017;Song et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Protective Actions of Acidic Hydrolysates of Polysaccharide Extracted From Mactra veneriformis Against Chemical-Induced Acute Liver Damage

Wang

Tan

et al. 2020

Front. Pharmacol.

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The present study aimed to explore the hepatoprotective effects of acidic hydrolysates of polysaccharide extracted from the marine clam M. veneriformis (Ah-MVPS) against ethanol-and CCl 4-induced liver damage. Moreover, we also seek to probe the mechanism associated with the liver protection effect of Ah-MVPS. A series of animal and cell experiments were executed to detect suitable serological and histological indicators in hepatic tissues. Ah-MVPS can significantly reduce liver damage by means of an increase in hepatocyte superoxidase dismutase and inhibition of leakages of alanine aminotransferase and aspartate transaminase, as well as through alleviation of malondialdehyde excalation. Ah-MVPS inhibited steatosis and water-like hepatic deterioration in histological examination. They can suppress membrane destruction in boundaries and the collapse of reticular scaffolds of injured mouse hepatocytes and can substantially reduce the inflammatory extent of liver tissue aroused by excessive intake of ethanol or CCl 4. In cell assays, Ah-MVPS markedly elevated the viability of L-02 cells exposed to an intoxication of ethanol or H 2 O 2. The beneficial effect of Ah-MVPS might arise, at least in part, because of the amelioration of peroxidation or oxidative stress. Taken together, our findings reveal that Ah-MVPS have potential for development as protective agents to attenuate acute liver injuries.

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Antioxidative and hepatoprotective effects of enzymatic and acidic-hydrolysis of Pleurotus geesteranus mycelium polysaccharides on alcoholic liver diseases

Cited by 33 publications

References 47 publications

Optimization of Ultrasonic-Microwave Assisted Extraction and Hepatoprotective Activities of Polysaccharides from Trametes orientalis

Optimization of Ultrasonic-Microwave Assisted Extraction and Hepatoprotective Activities of Polysaccharides from Trametes orientalis

Antioxidant and Hypolipidemic Activities of Acid-Depolymerised Exopolysaccharides by Termitomyces albuminosus

Protective Actions of Acidic Hydrolysates of Polysaccharide Extracted From Mactra veneriformis Against Chemical-Induced Acute Liver Damage

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