Antioxidative and gastroprotective activities of anti-inflammatory formulations derived from chestnut honey in rats

Nasuti, Cinzia; Gabbianelli, Rosita; Falcioni, Giancarlo; Cantalamessa, Franco

doi:10.1016/j.nutres.2006.02.007

Cited by 84 publications

(70 citation statements)

References 31 publications

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“…Total phenolic contents of the honeys ranged from 19 to 101 mg GAE/100 g. The ethanolic and phenolic contents were highest in heather, oak and chestnut honeys, while heterofloral blossom honeys and pine honeys exhibited the lowest levels. Our previous studies and other research have shown that oak, heather and chestnut honeys always exhibit higher phenolic compositions, as well as higher antioxidant capacities 17,[23][24][25][26][27] . Polyphenols in honeys are responsible for sensory properties, such as odor, color, aroma and taste, and biologically active properties, such as antioxidant, antimicrobial, antitumoral and anti-inflammatory activities 28 .…”

Section: Resultsmentioning

confidence: 99%

Honey shows potent inhibitory activity against the bovine testes hyaluronidase

Kolaylı

Şahin

Can

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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The purpose of this study was to investigate the anti-hyaluronidase activities of honeys from different botanical origins honeys in order to determine their anti-inflammatory properties. The total phenolic contents, total flavonoids and total tannin levels of six types of honey, chestnut, oak, heather, pine, buckwheat and mixed blossom, were determined. Concentrationrelated inhibition values were tested turbidimetrically on bovine testis hyaluronidase (BTHase) as IC 50 (mg/mL). All honeys exhibited various concentration-dependent degrees of inhibition against BTHase. Inhibition values varied significantly depending on honeys' levels of phenolic contents, flavonoid and tannin. The honeys with the highest anti-hyaluronidase activity were oak, chestnut and heather. In conclusion, polyphenol-rich honeys have high anti-hyaluronidase activity, and these honeys have high protective and complementary potential against hyaluronidase-induced anti-inflammatory failures.

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Section: Resultsmentioning

confidence: 99%

Honey shows potent inhibitory activity against the bovine testes hyaluronidase

Kolaylı

Şahin

Can

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…The extract of H. indicum reduced the gastric volume, free acidity, total acidity and hence ulcer index showing the anti-secretary mechanism 12 . HCl-Ethanol induced gastric damage ranging from endothelial microvascular damage to development of macroscopic gastric mucosal lesions, which is attributed mainly to the inhibition of biosynthesis of cytoprotective PG resulting in overproduction of leukotrienes and other products of the 5-lipoxygenase pathway 13 . These agents break the mucosal barrier, provoke an increase in gastric mucosal permeability to H + and Na + ions reducing the transmucosal potential difference and induce formation of erosions and ulcers.…”

Section: Resultsmentioning

confidence: 99%

Untitled

2011

IJPSR

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The objective of present study is to evaluate the anti ulcer activity of ethanol extract of leaves of Heliotropium indicum. The ethanol extract of H. indicum was investigated for its anti ulcer activity against Aspirin plus pylorus ligation induced gastric ulcer in rats, HCl-Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats. The antiulcer activity was assessed by determining and comparing gastric volume, free acidity and ulcer inhibition in aspirin plus pylorus ligation induced gastric ulcer model. The number of lesions in HCI-Ethanol induced peptic ulcer model and mean score value of ulcer inhibition in water immersion stress induced ulcer model. A significant antiulcer activity of plant extract was observed in all the models. Pylorus ligation model showed significant reduction in gastric volume, free acidity and ulcer index as compared to control. Also extract showed significant ulcer inhibition in HCl-Ethanol induced ulcer and ulcer protection index in stress induced ulcer. This present study indicates that Heliotropium indicum leaves extract have potential anti ulcer activity in the three models tested.

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“…These are attributed to the inhibition of prostaglandin production by cyclo-oxygenase resulting in overproduction of leukotrienes via. 5-lipoxygenase pathway [33]. These agents provoke the permeability of Na + and H + ions in the mucosal layer, producing mucosal erosions and damage of the cell membrane.…”

Section: Discussionmentioning

confidence: 99%

New Flavonoid Compound From Allium Hookeri Thwaites as a Gastroprotective Agent

Singh

Chetia

Biplab

2018

Int J Pharm Pharm Sci

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Objective: The main objective of this study was to investigate the antiulcer potential of an isolated flavonoid compound from Allium hookeri (AH). Methods:Oral administration of ethanol-induced ulcer to the mucosal layer of the stomach in the rats. The ulcer score and percentage protection was calculated from the stomach and gastric mucosal scrapping was carried out for the biochemical studies. Antioxidant study was carried out in liver and histopathological study of the ulcer stomach was performed.Results: Phytochemical investigation of methanolic extract of AH (MEAH) leaves afforded a new flavonoid compound characterized as 3, 5, 6-trihydroxy-2-(4-hydroxy-3-(6-hydroxy-4, 5, 6, 7-tetrahydro benzofuran-7-yl) phenyl-7-methoxy-4H-chromen-4-one (Compound 1). The flavonoid compound at the dose of 5 mg/kg showed a significant change in ulcer index by reducing the ulcer index and increased in percentage protection. It also increased the in vivo antioxidant activity by increasing the superoxide dismutase (SOD), glutathione (GLU) and catalase (CAT) levels. The isolated compound reversed the increase of mucin content in the mucosal scrapings. The histopathology study showed the reversed of normal gland texture in the mucous layer of the standard and compound 1 treated stomach when compared to the negative control. Conclusion:Present findings demonstrated the significant antiulcer activity and antioxidant activity of the isolated flavonoid compound as the supporting factor.

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Antioxidative and gastroprotective activities of anti-inflammatory formulations derived from chestnut honey in rats

Cited by 84 publications

References 31 publications

Honey shows potent inhibitory activity against the bovine testes hyaluronidase

Honey shows potent inhibitory activity against the bovine testes hyaluronidase

Untitled

New Flavonoid Compound From Allium Hookeri Thwaites as a Gastroprotective Agent

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