Antioxidative and antiinflammatory activities of quercetin-loaded silica nanoparticles

Lee, Ga Hyun; Lee, Sung June; Jeong, Sang Won; Kim, Hyun-Chul; Park, Ga Young; Lee, Se Geun; Choi, Jin Hyun

doi:10.1016/j.colsurfb.2016.03.060

Cited by 62 publications

(34 citation statements)

References 52 publications

(47 reference statements)

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“…As the antioxidant activity of morin did not decrease when is adsorbed onto the nanoparticles, this may indicate that the resorcinol moiety in B-ring, which is the most reactive site in the molecule against free radicals, is able to interact with hydroxyl radicals. For quercetin, which is structurally similar to morin by replacing the resorcinol in B-ring to a 3’,4’-cathecol moiety, when adsorbed onto silica NP, it has been documented a similar behavior against superoxide radical [93], indicating that the B-ring is free to react with the free radicals and that the linkage of this flavonoids to the NP takes place through the polar groups in A and C-rings [59, 94]. The antioxidant capacity against hydroxyl radical is summarized in Fig 9.…”

Section: Resultsmentioning

confidence: 99%

Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial

et al. 2016

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Morin (2´,3, 4´,5,7-pentahydroxyflavone) is a flavonoid with several beneficial health effects. However, its poor water solubility and it sensitivity to several environmental factors avoid its use in applications like pharmaceutical and cosmetic. In this work, we synthetized morin-modified mesoporous silica nanoparticles (AMSNPs-MOR) as useful material to be used as potential nanoantioxidant. To achieve this, we characterized its adsorption kinetics, isotherm and the antioxidant capacity as hydroxyl radical (HO•) scavenger and singlet oxygen (1O2) quencher. The experimental data could be well fitted with Langmuir, Freundlich and Temkin isotherm models, besides the pseudo-second order kinetics model. The total quenching rate constant obtained for singlet oxygen deactivation by AMSNPs-MOR was one order of magnitude lower than the morin rate constant reported previously in neat solvents and lipid membranes. The AMSNPs-MOR have good antioxidant properties by itself and exhibit a synergic effect with morin on the antioxidant property against hydroxyl radical. This effect, in the range of concentrations studied, was increased when the amount of morin adsorbed increased.

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Section: Resultsmentioning

confidence: 99%

Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial

et al. 2016

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“…Since last few years, the concept of nanotechnology, to improve bioavailability and targeted delivery of pharmacologically active drugs particularly lipophilic drugs to disease site, is under consideration however still numerous challenges and hurdles exist [28,29]. Different strategies, for bioavailability enhancement, have been employed so far in this regard such as topical route application [30], oral route of application [12], in vitro toxicity study [31] as well as the study of QUR nanoemulsion for surface methodology determination [32]; however, the accumulation of flavonoids in the brain due to blood-brain barrier (BBB) restriction is still a controversial question [33]. Various literature reports the less access of flavonoids in the brain due to BBB [33], but on contrary free QUR has been found to accumulate more in brain tissues and exert better antioxidative effects [33].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Intranasal delivery of quercetin-loaded mucoadhesive nanoemulsion for treatment of cerebral ischaemia

Ahmad¹,

Naqvi

Alam

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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“…Elevated SOD and CAT activites, GSH levels and amelioration of lipid peroxidation and protein carbonylation were also observed in alloxan-induced diabetic mice treated with quercetin-loaded nanorods (Alam et al, 2016). In addition, quercetin-loaded silica nanoparticles were found to be able to ameliorate inflammatory conditions in different cell lines (Lee et al, 2016).…”

Section: Nano-quercetinmentioning

confidence: 94%

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Vaiserman

Koliada

Zayachkivska

et al. 2020

Front. Bioeng. Biotechnol.

143

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The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.

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Antioxidative and antiinflammatory activities of quercetin-loaded silica nanoparticles

Cited by 62 publications

References 52 publications

Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial

Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial

RETRACTED ARTICLE: Intranasal delivery of quercetin-loaded mucoadhesive nanoemulsion for treatment of cerebral ischaemia

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

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