Antioxidative and anticancer properties of Licochalcone A from licorice

Chen, Xiangrong; Liu, Zuojia; Meng, Rizeng; Shi, Ce; Guo, Na

doi:10.1016/j.jep.2017.01.028

Cited by 65 publications

(39 citation statements)

References 33 publications

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“…In traditional Chinese medicine, the roots and rhizomes of a variety species of the perennial herb licorice are used for the treatment of a number of conditions, including fatigue, asthma and excessive phlegm production, and for relieving drug toxicity ( 7 ). One study demonstrated that Chinese licorice inhibits the growth of HepG2 cells by arresting cell proliferation and the subsequent induction of apoptosis ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells

et al. 2018

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Gastric cancer most commonly occurs in East Asia, and China accounts for more than half the of world's gastric cancer burden. Despite the efficacy of chemotherapy for patients, this treatment leads to significant patient inconvenience, toxicity and cost. The present study aimed to assess a non-toxic agent, glabridin, as a future chemotherapeutic approach for treating gastric cancer. Using cell proliferation, apoptosis, invasion, and colony formation assays, it was determined that glabridin alone, or in combination with 5-fluorouracil (5-FU), inhibited MKN-45 cell proliferation and invasion, and increased apoptosis. These effects were accompanied by downregulation of p16, E-cadherin and apoptosis regulator Bcl-2 protein, and upregulation of N-cadherin, apoptosis regulator BAX and caspases 3, 8 and 9. The results demonstrated that glabridin may inhibit the malignant proliferation of the human gastric cancer MKN-45 cell line and enhance the efficiency of 5-FU. The data indicate that the p16, and potentially the p16/cyclin-dependent kinase 4/cyclin D1 pathway, may be a novel target for gastric cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells

et al. 2018

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“…Previous phytochemical studies show that S. adstringens stem bark has proanthocyanidins [7,32], chalcones and triterpene compounds [4]. Those compounds are described for their antioxidant and anticancer activities [33,34,35,36]. …”

Section: Discussionmentioning

confidence: 99%

Evaluation of In Vitro Antioxidant and Anticancer Properties of the Aqueous Extract from the Stem Bark of Stryphnodendron adstringens

Baldivia

Leite

Castro

et al. 2018

IJMS

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Stryphnodendron adstringens (Mart.) Coville (Fabaceae) is a tree species native to the Brazilian Cerrado commonly known as barbatimão. In traditional medicine, decoctions or infusions of the stem bark of this plant are used in the treatment of several diseases. The objective of this study was to analyze the chemical composition of Stryphnodendron adstringens aqueous extracts (SAAE) prepared from the stem bark to assess their antioxidant activity and anticancer effects as well as characterize cell death mechanisms against murine B16F10Nex-2 melanoma cells. From the SAAE, gallic acid, gallocatechin, epigallocatechin, dimeric and trimeric proanthocyanidins mainly composed of prodelphinidin units and the isomeric chromones C-hexosyl- and O-pentosyl-5,7-dihydroxychromone were identified. The SAAE showed antioxidant activity through direct free-radical scavenging as well as through oxidative hemolysis and lipid peroxidation inhibition in human erythrocytes. Furthermore, SAAE promoted apoptosis-induced cell death in melanoma cells by increasing intracellular reactive oxygen species (ROS) levels, inducing mitochondrial membrane potential dysfunction and activating caspase-3. Together, these data show the antioxidant and anticancer effects of Stryphnodendron adstringens. These results open new perspectives for studies against other tumor cell lines and in vivo models as well as for the identification and isolation of the chemical constituents responsible for these effects.

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“…Evidence-Based Complementary and Alternative Medicine cells from oxidative stress by activating Nrf2-signaling, resulting in increased expression of HO-1 and glutamatecysteine ligase regulatory subunit (GCLM) and reduction of intracellular ROS concentration [97]. Moreover, licochalcones A and C increased the expression of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) proteins that were closely related to antioxidant mechanisms [98,99]. Glypallichalcone, the inhibitor of LDL oxidation, reduced cholesterol levels through modulation of β-1 adrenergic receptor [101].…”

Section: Antioxidative Activitymentioning

confidence: 99%

Natural Chalcones in Chinese Materia Medica: Licorice

Wang

Liang

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Licorice is an important Chinese materia medica frequently used in clinical practice, which contains more than 20 triterpenoids and 300 flavonoids. Chalcone, one of the major classes of flavonoid, has a variety of biological activities and is widely distributed in nature. To date, about 42 chalcones have been isolated and identified from licorice. These chalcones play a pivotal role when licorice exerts its pharmacological effects. According to the research reports, these compounds have a wide range of biological activities, containing anticancer, anti-inflammatory, antimicrobial, antioxidative, antiviral, antidiabetic, antidepressive, hepatoprotective activities, and so on. This review aims to summarize structures and biological activities of chalcones from licorice. We hope that this work can provide a theoretical basis for the further studies of chalcones from licorice.

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Antioxidative and anticancer properties of Licochalcone A from licorice

Cited by 65 publications

References 33 publications

Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells

Effects of glabridin combined with 5-fluorouracil on the proliferation and apoptosis of gastric cancer cells

Evaluation of In Vitro Antioxidant and Anticancer Properties of the Aqueous Extract from the Stem Bark of Stryphnodendron adstringens

Natural Chalcones in Chinese Materia Medica: Licorice

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