Natural Chalcones in Chinese Materia Medica: Licorice

Wang, Danni; Liang, Jing; Zhang, Jing; Wang, Yuefei; Chai, Xin

doi:10.1155/2020/3821248

Cited by 33 publications

(29 citation statements)

References 134 publications

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“…Moreover, the licorice root contains also chalcones [ 43 ]. Several licorice chalcones have recently shown to have antiproliferative properties by inducing several mechanisms of cell death including apoptosis [ 44 ]. Recently, isoliquiritigenin (ISL) has been shown to induce apoptosis in non-small cell lung cancer cells (NSCLC).…”

Section: Induction Of Cell Deathmentioning

confidence: 99%

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

Michalková¹,

Mirossay²,

Gazdova³

et al. 2021

Cancers

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Although great progress has been made in the treatment of cancer, the search for new promising molecules with antitumor activity is still one of the greatest challenges in the fight against cancer due to the increasing number of new cases each year. Chalcones (1,3-diphenyl-2-propen-1-one), the precursors of flavonoid synthesis in higher plants, possess a wide spectrum of biological activities including antimicrobial, anti-inflammatory, antioxidant, and anticancer. A plethora of molecular mechanisms of action have been documented, including induction of apoptosis, autophagy, or other types of cell death, cell cycle changes, and modulation of several signaling pathways associated with cell survival or death. In addition, blockade of several steps of angiogenesis and proteasome inhibition has also been documented. This review summarizes the basic molecular mechanisms related to the antiproliferative effects of chalcones, focusing on research articles from the years January 2015–February 2021.

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Section: Induction Of Cell Deathmentioning

confidence: 99%

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

Michalková¹,

Mirossay²,

Gazdova³

et al. 2021

Cancers

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“…Natural antioxidant extracts have been found to have similar activity as chemically synthesized antioxidants against the oxidation of edible oils. One of these popular plants is licorice root ( Glycyrrhiza uralensis ), which is an important Chinese materia medica frequently used in clinical practice [ 20 ]. Licorice contains different types of phytochemicals, such as tripenoids, flavanones, chalcones, and coumarins and their glycosides.…”

Section: Introductionmentioning

confidence: 99%

“…To date, about 42 chalcones have been isolated, identified, and categorized as nontoxic natural ingredients [ 21 , 22 ]. The chalcone isoliquiritigenin (2,4,4′-trihydroxychalcone) is one of the main bioactive components in licorice and has antioxidant properties, as well as estrogenic and antitumor action [ 20 , 23 ]. However, no study has been conducted to determine the efficacy of 2,4,4′-trihydroxychalcone in preventing lipid oxidation under storage conditions.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of the Natural Antioxidant 2,4,4′-Trihydroxychalcone on the Oxidation of Sunflower Oil during Storage

Alsufiani

Ashour

2021

Molecules

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This study aimed to investigate the effectiveness of 2,4,4′-trihydroxychalcone as a natural antioxidant on the oxidation of sunflower oil during an 88-day storage period and to compare its strength with the synthetic antioxidant butylated hydroxytoluene (BHT). Seven groups of the sunflower oil samples were prepared: pure oil (control), oil treated with different concentrations (100, 500, and 1000 ppm) of 2,4,4′-trihydroxychalcone, and oil treated with different concentrations (100, 500, and 1000 ppm) of BHT. Specific parameters, namely, the peroxide value (PV), acid value (AV), p-anisidine value (p-AnV), thiobarbituric acid reactive substance (TBARS) value and total oxidation (TOTOX) value were used to assess the extent of the deterioration of the oil by estimating the primary and secondary oxidation products. The results showed that 2,4,4′-trihydroxychalcone effectively decreased the production of the primary and secondary oxidation products of sunflower oil during storage, as indicated by reductions in the PVs, AVs, p-AnVs, TBARS values and TOTOX values of the sunflower oil. When compared to BHT, 2,4,4′-trihydroxychalcone showed either a similar or stronger effect in inhibiting the primary and secondary oxidation products. These findings suggest that, 2,4,4′-trihydroxychalcone is a suitable natural alternative to synthetic antioxidants to improve the oxidative stability of sunflower oil.

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“…Ambawade et al, 2001 also reported that hydroalcoholic extract of GG exhibited potent anxiolytic activity (21). The bioactive compound of GG is ISL, a flavonoid chalcone, easily passes through the blood brain barrier which suggesting that liquiritigenin attenuates anxiety-like behavior and discovered to have neuroprotective effects (22).…”

Section: Resultsmentioning

confidence: 99%

Neuroprotective role of Glycyrrhiza glabra on chronic noise induced changes in Hippocampal morphology and its functions in wistar albino rats

Arjunan¹,

Sah²,

Rajan³

2021

IJAM

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Background: Noise has become inexorable stress due to the increase in urbanization, automobile usage, and lifestyle modification.Aim: The study aims to investigate the effect of chronic noise stress on hippocampal morphology and the neuroprotective effect of Glycyrrhiza glabra (GG) on stress-induced male Wistar albino rats. Methods: Adult albino rats were randomly divided into four groups. Each group contained six animals. Rats exposed to chronic noise stress (100 dB/4 h – 30Days), Noise + GG (150 mg/kg Bw/Oral), and GG alone were compared with control animal and assessed for behaviour using the hole-board test, marble burying test, the morphology of hippocampus by histology, DNA fragmentation and assessed the Phytochemical constitutes in GG. Results: The rats exposed to chronic noise stress showed significance (p<0.05) of behavioral alterations such as increased fear and anxiety, obsessive-compulsive behaviour, enlarged lateral ventricle, and reduced hippocampal volume. Conclusion: The results reported that chronic noise stress affects the neurobehavioral due to reduced hippocampal volume.

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Natural Chalcones in Chinese Materia Medica: Licorice

Cited by 33 publications

References 134 publications

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

Effectiveness of the Natural Antioxidant 2,4,4′-Trihydroxychalcone on the Oxidation of Sunflower Oil during Storage

Neuroprotective role of Glycyrrhiza glabra on chronic noise induced changes in Hippocampal morphology and its functions in wistar albino rats

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