Antioxidative Activity of Water Extracts of<i>Lagerstroemia speciosa</i>Leaves

Unno, Toshihiro; Sakane, Iwao; Masumizu, Toshiki; Kohno, Masahiro; Kakuda, Takami

doi:10.1271/bbb.61.1772

Cited by 35 publications

(18 citation statements)

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“…The results of this study thus strongly suggested that extract has an anti-oxidant property. This is consistent with the results published by Unno et al, 1997. The antidiabetic and the antioxidant properties of the extract might be acting in a synergistic fashion.…”

Section: Resultssupporting

confidence: 93%

Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action

Saha

Bhuiyan

Mazumder

et al. 2009

Bangladesh J Pharmacol

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The hypoglycemic effect of Lagerstroemia speciosa L. leaves hot water extract on chemically induced diabetes in rat was investigated. Experimental result showed that, streptozotocin significantly (p<0.001) elevated the normal blood sugar level whereas treatment with hot water extract depressed the streptozotocin-induced high blood sugar level about 43.2% as compare to diabetic controls. Treatment with hot water extract increased the activity of shunt enzyme glucose-6-phosphate dehydrogenase (33.8%) and glutathione level (31.3%) and depression of the activity of hepatic gluconeogenic enzymes glucose-6-phasphatase (31.6%) and fructose-1,6-bisphosphatase (27.4%). These studies thus strongly suggest that the hot water extract of L. speciosa leave attributed its prominent hypoglycemic activity on experimental diabetic rats through suppression of gluconeogenesis and stimulation of glucose oxidation using the pentose phosphate pathway.

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Section: Resultssupporting

confidence: 93%

Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action

Saha

Bhuiyan

Mazumder

et al. 2009

Bangladesh J Pharmacol

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“…However, the people of South-east Asia used the leaves of L. speciosa for the treatment of diabetes mellitus and obesity [2]. The aqueous extract of leaves of L. speciosa leaves possess potent antioxidant and free radical scavenging activities by scavenging 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) and superoxide radical as well as inhibiting lipid peroxidation [3]. Moreover, the bioactive phytochemicals isolated from different parts of L. speciosa , have revealed hypoglycemic, antibacterial, anti-inflammatory, antioxidant and hepato protective properties [4–9].…”

Section: Introductionmentioning

confidence: 99%

Radical Scavenging Activities of Lagerstroemia speciosa (L.) Pers. Petal Extracts and its hepato-protection in CCl4-intoxicated mice

Tiwary

Dutta

Dey

et al. 2017

BMC Complement Altern Med

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Background Lagerstroemia speciosa (L.) Pers. has medicinal importance. Bioactive phytochemicals isolated from different parts of L. speciosa, have revealed hypoglycemic, antibacterial, anti-inflammatory, antioxidant and hepato protective properties. Despite one report from Philippines detailing the use of L. speciosa as curative for fever and as well as diuretic, there is no experimental evidence about the hepatoprotective activity of the flower extracts.MethodsSeveral spectroscopic methods, including GC–MS, were used to characterize phytochemicals present in the petal extract of L. speciosa. Ethanol extract of petals was evaluated for anti-oxidant and free radical scavenging properties by using methods related to hydrogen atom transfer, single electron transfer, reducing power, and metal chelation. This study has also revealed the in vitro antioxidant and in vivo hepatoprotective properties of petal extract against carbon tetra chloride (CCl4)-induced liver toxicity in Swiss albino mice. Hepatoprotection in CCl4 -intoxicated mice was studied with the aid of histology and different enzymatic and non-enzymatic markers of liver damage. Cytotoxicity tests were done using murein spleenocytes and cancareous cell lines, MCF7 and HepG2.ResultGCMS of the extract has revealed the presence of several potential antioxidant compounds, of them γ-Sitosterol and 1,2,3-Benzenetriol (Pyrogallol) were the predominant ones. The antioxidants activities of the flower-extract were significantly higher than curcumin (in terms of Nitric oxide scavenging activity; p = 0.0028) or ascorbic acid (in terms of 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) assay; p = 0.0022). The damage control by the flower extract can be attributed to the reduction in lipid peroxidation and restoration of catalase activity. In vitro cytotoxicity tests have shown that the flower extract did not affect growth and survivability of the cell lines. It left beyond doubt that a flower of L. speciosa is a reservoir of antioxidant and hepatoprotective agents capable of reversing the damage inflicted by CCl4-intoxication.ConclusionResults from the present study may be used in developing a potential hepato-protective health drink enriched with antioxidants from Lagerstroemia speciosa (L.) Pers.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1495-0) contains supplementary material, which is available to authorized users.

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“…Interest is increasing in the protective biological effects of some natural antioxidants, especially from edible plants, which are candidates for preventing various inflammatory disorders and extending the life span of humans (Unno et al 1997;Yang et. al 1998;Virgili et al 1998;Wakabayashi 1999).…”

Section: Discussionmentioning

confidence: 99%

Effects of Apocynin and Natural Antioxidant from Spinach on Inducible Nitric Oxide Synthase and Cyclooxygenase‐2 Induction in Lipopolysaccharide‐Induced Hepatic Injury in Rat

Lomnitski

Foley

Grossman

et al. 2000

Pharmacology & Toxicology

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Abstract:The immunoreactivity of inducible nitric oxide synthase, and cyclooxygenase-2 was compared among groups of male Wistar rats comprising those injected with lipopolysaccharide following pretreatment with either natural antioxidant from spinach or the antioxidant apocynin, with lipopolysaccharide without pretreatment with antioxidants, with each of the two antioxidants alone, and untreated controls. The grade of staining of both inducible nitric oxide synthase and cyclooxygenase-2 increased with the severity of the inflammatory reaction in the lipopolysaccharide-treated animals, compared to the antioxidant-treated groups. Interpretation of the results of the immunostained tissues indicated that pretreatment with either antioxidant significantly (P∞0.05) attenuated the lipopolysaccharide-stimulated inducible nitric oxide synthase induction. Analysis of the cycloxygenase-2-stained liver samples indicated that the pretreatment with the natural antioxidant NAO significantly (P∞0.05) attenuated lipopolysaccharide-stimulated cycloxygenase-2 induction; whereas, in animals pretreated with apocynin, there was a trend of reduction in the cyclooxygenase-2 expression, but not statistically significant (P±0.05). The negative nitrotyrosine immunoreactivity of the lipopolysaccharide-related hepatic lesions may indicate that there was relatively low interaction between superoxide anions and nitric oxide to form peroxynitrite or that the expression levels of the nitrotyrosine were below the limit of detection. In all treatment groups a positive correlation (P∞0. 05, rΩ0.86) found between the inducible nitric oxide synthase and cyclooxygenase-2 scores suggests a strong relationship between these two parameters. The results indicate the possible therapeutic efficacy of NAO and apocynin in the prevention of liver damage related to clinical endotoxemia known to be associated with oxidative stress.

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Antioxidative Activity of Water Extracts ofLagerstroemia speciosaLeaves

Cited by 35 publications

References 1 publication

Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action

Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action

Radical Scavenging Activities of Lagerstroemia speciosa (L.) Pers. Petal Extracts and its hepato-protection in CCl4-intoxicated mice

Effects of Apocynin and Natural Antioxidant from Spinach on Inducible Nitric Oxide Synthase and Cyclooxygenase‐2 Induction in Lipopolysaccharide‐Induced Hepatic Injury in Rat

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