Antioxidative Activity of Hop Bitter Acids and Their Analogues

Tagashira, Motoyuki; Watanabe, Motoshi; Uemitsu, Nobuo

doi:10.1271/bbb.59.740

Cited by 93 publications

(55 citation statements)

References 3 publications

(3 reference statements)

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“…Hop extracts and/or compounds have been reported to be "active" or the equivalent by the authors of the given studies in the following assays: various antioxidant and/or chemoprevention (Gerhäuser et al, 2002;Gerhäuser et al, 2001;Liegeois et al, 2000;Masaki et al, 1995;Oyaizu et al, 1994;Stevens et al, 2002;Tagashira et al, 1995), antimicrobial, particularly against Gram positive bacteria (Grange and Davey, 1990;Langezaal et al, 1992;Matos et al, 2001;Ohsugi et al, 1997;Racz et al, 1980;Simpson and Smith, 1992;Tagashira et al, 1997), and cytotoxicity (Bae et al, 1996;Liu et al, 2001;Miranda et al, 1999;Shipp et al, 1994). Many constituents have been reported from hops (Farnsworth, 2003), among which in addition to the aforementioned estrogenic properties, many have been shown to possess other types of biological activity (Honma et al, 1998;Shipp et al, 1994;Tabata et al, 1998;Tobe et al, 1995;Tobe et al, 1997;Yasukawa et al, 1995) such as potential cancer chemopreventive activity (Gerhäuser et al, 2001a;Miranda et al, 2000a) and suppression of COX-2 gene transcription (Yamamoto et al, 2000).…”

Section: Other Activitiesmentioning

confidence: 99%

The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties

2006

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SummaryAs the population ages, there is an ever-increasing need for therapeutic agents that can be used safely and efficaciously to manage symptoms related to postmenopausal estrogen deficiency. Endogenous estrogens, e.g., 17β-estradiol, of exogenous mammalian origin, e.g., horses, have long been used to manage such symptoms. There are more than twenty different classes of phytochemicals that have demonstrated affinity for human estrogen receptors in vitro. Some studies on exogenous estrogenic substances of botanical origin ("phytoestrogens"), such as standardized formulations of plant extracts with in vitro and in vivo estrogenic activity from soy (Glycine max Merill.) and red clover (Trifolium pratense L.), suggest clinical efficacy. Few clinical data for phytoestrogens other than isoflavonoids are available. In an exhaustive review of the literature through 2003, only two clinical trials were identified that were designed to evaluate the effect of hops (Humulus lupulus L.) on symptoms related to manopause. Folkloric, chemical, and biological literature relating primarily to the use of hops for their estrogenic activity, and two human clinical trials, are reviewed.

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Section: Other Activitiesmentioning

confidence: 99%

The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties

2006

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“…Some of the hop components are bioactive agents. For example, the hop bitter acids have antibiotic l ) and antioxidative 2 ) activities, and hop cones have been reported to contain some bioactive substances which have an estrogen-like activity 3 -5) or a gonadotropin inhibitory activity. 6) Unfortunately, they have not been isolated nor identified in detail, necessitating further investigation on unknown biological activities in hop plants.…”

mentioning

confidence: 99%

Inhibition by Hop Bract Polyphenols of Cellular Adherence and Water-insoluble Glucan Synthesis of Mutans Streptococci

Tagashira

Uchiyama

Yoshimura

et al. 1997

Bioscience, Biotechnology, and Biochemistry

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“…Humulones and lupulones have radical-scavenging and lipid peroxidation inhibitory activity [92]. These effects might contribute to the potent inhibition of bone resorption.…”

Section: Hop Bitter Acids: Alpha-acids and Iso-alpha Acidsmentioning

confidence: 99%

European Journal of Cancer

2007

European Journal of Cancer

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Beer is a complex alcoholic beverage made from barley (malt), hop, water and yeast. Phenolic constituents of beer are derived from malt (70-80%) and hop (20-30%). Structural classes include simple phenols, benzoic-and cinnamic acid derivatives, coumarins, catechins, di-, tri-and oligomeric proanthocyanidins, (prenylated) chalcones and flavonoids as well as alpha-and iso-alphaacids derived from hop. Compounds belonging to different structural classes have distinct profiles of biological activity in in vitro test systems, and in combination might lead to enhanced effects. Scientific evidence has accumulated over the past 10 years pointing to the cancer preventive potential of selected hop-derived beer constituents, i.e., prenylflavonoids including xanthohumol and isoxanthohumol, and hop bitter acids. Chemopreventive activities observed with these compounds relevant to inhibition of carcinogenesis at the initiation, promotion and progression phases, as well as results from in vivo studies on metabolism, bioavailability and efficacy are summarised in this review.

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Antioxidative Activity of Hop Bitter Acids and Their Analogues

Cited by 93 publications

References 3 publications

The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties

The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties

Inhibition by Hop Bract Polyphenols of Cellular Adherence and Water-insoluble Glucan Synthesis of Mutans Streptococci

European Journal of Cancer

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