Inhibition by Hop Bract Polyphenols of Cellular Adherence and Water-insoluble Glucan Synthesis of Mutans Streptococci

Tagashira, Motoyuki; Uchiyama, Koichi; Yoshimura, Tomoaki; Shirota, M; Uemitsu, Nobuo

doi:10.1271/bbb.61.332

Cited by 77 publications

(66 citation statements)

References 7 publications

(7 reference statements)

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“…In vivo rat studies of the extract from Lentinus edodes, the most popular edible mushroom in Japan (18), showed an inhibitory effect on water-insoluble glucan formation by glucosyltransferase. A similar effect has been described for apple procyanidins in vitro (19) and for hop bract high molecular weight components (20). Cacao mass extract displayed cariostatic activity in vitro and in animal experiments (21).…”

Section: Introductionsupporting

confidence: 74%

Antibacterial Activity of Red and White Wine against Oral Streptococci

Daglia

Papetti

Grisoli

et al. 2007

J. Agric. Food Chem.

108

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Wine contains a number of biologically active compounds with beneficial effects on human health. The antibacterial action of commercial red and white wines against oral streptococci responsible for caries development and against S. pyogenes responsible for pharyngitis was studied. Its postcontact effect against S. mutans was also studied. Both wines displayed activity. The compounds responsible for such activities were succinic, malic, lactic, tartaric, citric, and acetic acid. The synthetic mixtures of the organic acids tested at the concentrations found in wine had greater antibacterial activity than the beverages, indicating that in wine they are inhibited by other components. Wine polyphenols displayed no activity against oral streptococci or S. pyogenes. Findings show that wine is active against oral streptococci and S. pyogenes and suggest that it enhances oral health.

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Section: Introductionsupporting

confidence: 74%

Antibacterial Activity of Red and White Wine against Oral Streptococci

Daglia

Papetti

Grisoli

et al. 2007

J. Agric. Food Chem.

108

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show abstract

“…Hop extracts and/or compounds have been reported to be "active" or the equivalent by the authors of the given studies in the following assays: various antioxidant and/or chemoprevention (Gerhäuser et al, 2002;Gerhäuser et al, 2001;Liegeois et al, 2000;Masaki et al, 1995;Oyaizu et al, 1994;Stevens et al, 2002;Tagashira et al, 1995), antimicrobial, particularly against Gram positive bacteria (Grange and Davey, 1990;Langezaal et al, 1992;Matos et al, 2001;Ohsugi et al, 1997;Racz et al, 1980;Simpson and Smith, 1992;Tagashira et al, 1997), and cytotoxicity (Bae et al, 1996;Liu et al, 2001;Miranda et al, 1999;Shipp et al, 1994). Many constituents have been reported from hops (Farnsworth, 2003), among which in addition to the aforementioned estrogenic properties, many have been shown to possess other types of biological activity (Honma et al, 1998;Shipp et al, 1994;Tabata et al, 1998;Tobe et al, 1995;Tobe et al, 1997;Yasukawa et al, 1995) such as potential cancer chemopreventive activity (Gerhäuser et al, 2001a;Miranda et al, 2000a) and suppression of COX-2 gene transcription (Yamamoto et al, 2000).…”

Section: Other Activitiesmentioning

confidence: 99%

The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties

2006

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SummaryAs the population ages, there is an ever-increasing need for therapeutic agents that can be used safely and efficaciously to manage symptoms related to postmenopausal estrogen deficiency. Endogenous estrogens, e.g., 17β-estradiol, of exogenous mammalian origin, e.g., horses, have long been used to manage such symptoms. There are more than twenty different classes of phytochemicals that have demonstrated affinity for human estrogen receptors in vitro. Some studies on exogenous estrogenic substances of botanical origin ("phytoestrogens"), such as standardized formulations of plant extracts with in vitro and in vivo estrogenic activity from soy (Glycine max Merill.) and red clover (Trifolium pratense L.), suggest clinical efficacy. Few clinical data for phytoestrogens other than isoflavonoids are available. In an exhaustive review of the literature through 2003, only two clinical trials were identified that were designed to evaluate the effect of hops (Humulus lupulus L.) on symptoms related to manopause. Folkloric, chemical, and biological literature relating primarily to the use of hops for their estrogenic activity, and two human clinical trials, are reviewed.

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“…Even today, hop is used as a tranquilizer in folk medicine [5]. Xanthohumol (XN), which has a prenylated chalcone structure (Fig.…”

Section: Introductionmentioning

confidence: 99%

In vitro glucuronidation of xanthohumol, a flavonoid in hop and beer, by rat and human liver microsomes

2001

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Xanthohumol (XN) is the major prenylated flavonoid of hop plants and has been detected in beer. Previous studies suggest a variety of potential cancer chemopreventive effects for XN, but there is no information on its metabolism. The aim of this study was to investigate in vitro glucuronidation of XN by rat and human liver microsomes. Using high-performance liquid chromatography, two major glucuronides of XN were found with either rat or human liver microsomes. Release of the aglycone by enzymatic hydrolysis with L L-glucuronidase followed by liquid chromatography/mass spectrometry and nuclear magnetic resonance analysis revealed that these were C-4P P and C-4 monoglucuronides of XN. ß

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Inhibition by Hop Bract Polyphenols of Cellular Adherence and Water-insoluble Glucan Synthesis of Mutans Streptococci

Cited by 77 publications

References 7 publications

Antibacterial Activity of Red and White Wine against Oral Streptococci

Antibacterial Activity of Red and White Wine against Oral Streptococci

The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties

In vitro glucuronidation of xanthohumol, a flavonoid in hop and beer, by rat and human liver microsomes

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