Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice

Nan, Yuemin; Wu, Wenjuan; Fu, Na; Liang, Bao-Li; Wang, Rongqi; Li, Liang-Xiao; Zhao, Suxian; Zhao, Jingmin; Yu, Jun

doi:10.1080/00365520903114912

Cited by 90 publications

(65 citation statements)

References 37 publications

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“…Oxidative stress may damage cellular structures via lipid peroxidation of cellular membranes producing toxic metabolites [36] . In this study, vitamin E increased the antioxidant defense (increased activity of SOD and level of GSH) and attenuated the hepatic MDA level, as well as, TNF-α that may underlie the improvement of fructoseinduced metabolic and hepatic disorders by vitamin E that come in agreement with previous reports of Traber and Stevens [7] , and Nan et al [37] .…”

Section: Discussionsupporting

confidence: 81%

Effects of Liraglutide and Vitamin E in Fructose-Induced Metabolic Syndrome in Rats

Geddawy

Hussian²,

Kamel³

et al. 2016

Pharmacology

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Background: Metabolic syndrome (MetS) is a growing worldwide health problem. However, there is yet no effective therapy for MetS. The present work investigated the effect of liraglutide, a synthetic glucagon-like peptide-1 and vitamin E on fructose-induced MetS in rats. Summary: Liraglutide (0.3 mg/kg/day) and vitamin E (100 mg/kg/day) were administered either alone or in combination with high fructose-fed male rats for 6 weeks. Fructose-fed rats developed metabolic disorders assessed by visceral fat index, serum glucose, serum insulin, homeostasis model assessment-insulin resistance and serum lipids profile and hepatic disorders assessed by liver index, serum alanine aminotransferase and aspartate aminotransferase and steatohepatitis in histopathology. This study showed that liraglutide, vitamin E and their combination significantly ameliorated the fructose-induced metabolic and hepatic disorders. Key Messages: These results indicate a potential therapeutic benefit of liraglutide and vitamin E combination in prevention of MetS. Their protective effects might rely on their antioxidant effects as well as on the inhibition of tumor necrosis factor-α.

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Section: Discussionsupporting

confidence: 81%

Effects of Liraglutide and Vitamin E in Fructose-Induced Metabolic Syndrome in Rats

Geddawy

Hussian²,

Kamel³

et al. 2016

Pharmacology

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“…In rats fed a methionine-choline deficient diet (MCD) to induce NASH, α-tocopherol supplementation decreased histologic evidence of liver steatosis, inflammation, and fibrosis, decreased hepatic lipid peroxidation, and restored hepatic glutathione [37]. Likewise, mice fed a MCD and α-tocopherol had lower serum aminotransferase activities and hepatic MDA concurrently with improved histologic scores of hepatic steatosis and necroinflammation [38]. These were also accompanied by a suppression in hepatic nuclear factor kappa B activity, cyclooxygenase (COX)-2 protein levels, and increases in hepatic superoxide dismutase activity.…”

Section: Discussionmentioning

confidence: 99%

Dietary α- and γ-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis

Chung

Yeung

Park

et al. 2010

The Journal of Nutritional Biochemistry

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“…Some cases can progress to NASH and cirrhosis. Oxidative stress plays a key role in the development of NASH [28]. As a result, theoretically, antioxidative should be effective in the treatment of NASH.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of probucol on liver injury induced by carbon tetrachloride in rats

Zhan

Weng

et al. 2011

Hepatol Int

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For the first time, we demonstrated that probucol has protective effect against liver injury in animal experiment. The antioxidant action of probucol may play an important role in its hepatoprotective mechanism. Probucol also can reduce serum cholesterol. Thus, probucol may have the potential use in clinical liver diseases in which oxidative stress may be present, especially for the patients with hypercholesterolemia.

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Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice

Abstract: The present study provides morphological and molecular biological evidence for the protective role of the antioxidant vitamins E and ABT in ameliorating oxidative stress, hepatic apoptosis, and necroinflammation in experimental nutritional steatohepatitis.

Cited by 90 publications

References 37 publications

Effects of Liraglutide and Vitamin E in Fructose-Induced Metabolic Syndrome in Rats

Effects of Liraglutide and Vitamin E in Fructose-Induced Metabolic Syndrome in Rats

Dietary α- and γ-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis

Protective effect of probucol on liver injury induced by carbon tetrachloride in rats

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