Dietary α- and γ-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis

Chung, Min‐Yu; Yeung, Steven F; Park, Hea Jin; Volek, Jeff S.; Bruno, Richard S.

doi:10.1016/j.jnutbio.2009.10.006

Cited by 70 publications

(44 citation statements)

References 45 publications

(67 reference statements)

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“…Intestinal-derived bacterial lipopolysaccharide (LPS) has also been implicated in causing progressive liver injury in subjects with fatty liver, with animal models of fatty liver demonstrating increased hepatitis and liver injury after LPS exposure ( 40,41 ). Humans with NASH may be predisposed to LPS-stimulated liver injury related to small bowel bacterial overgrowth and increased intestinal permeability ( 34 ).…”

Section: Heritability Of Hepatic Steatosismentioning

confidence: 99%

Genetic determinants of hepatic steatosis in man

Hooper

Adams

Burnett

2011

Journal of Lipid Research

115

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in childhood in some individuals, with a prevalence of 10% found in an autopsy study of 2-19 year olds from the United States ( 5 ). The prevalence of NAFLD increases with advancing age, with a peak between 40 and 69 years of age ( 2, 6 ).A cut-off of 5.5% hepatic steatosis has been accepted as the threshold to diagnose fatty liver, based on the 95th centile of hepatic fat content in low-risk subjects [normal body mass index (BMI), normal glucose tolerance, lack of excessive alcohol ingestion, and normal liver function tests] ( 1, 7 ). Subjects with NAFLD may have a range of histopathological changes (

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Section: Heritability Of Hepatic Steatosismentioning

confidence: 99%

Genetic determinants of hepatic steatosis in man

Hooper

Adams

Burnett

2011

Journal of Lipid Research

115

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“…Induction of hepatic fibrosis and tumorigenesis in rats by NDMA occur via the activation of CYP 450 enzymes (George et al, 2001;Kasprzyk-Hordern et al, 2005), which adversely affects biochemical and molecular parameters defining liver function (Ahmad et al, 2009;George & Chandrakasan, 2000;Krajka-Kuzniak et al, 2012). Changes in fibrotic liver also include modulation in functions or levels of vitamins, which are important participants during recovery of liver from diseased conditions (Chattopadhyay et al, 2012;Chung et al, 2010;Himmerich et al, 2001). While several published reports dealing with the effects of vitamins C and E in recovery of hepatic disorders are available (Harrison et al, 2003;Kugelmas et al, 2003), the role of vitamin B 12 in alleviating fibrosis is still being debated and needs additional evidence.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B₁₂supplement alleviatesN′-nitrosodimethylamine-induced hepatic fibrosis in rats

Ahmad

Afroz

Gupta

et al. 2014

Pharmaceutical Biology

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Context: Altered vitamin B 12 levels have been correlated with hepatotoxicity; however, further evidence is required to establish its protective role. Objective: To evaluate the effects of vitamin B 12 supplement in protecting N 0 -nitrosodimethylamine (NDMA)-induced hepatic fibrosis in Wistar rats. Materials and methods: Hepatic fibrosis was induced by administering NDMA in doses of 10 mg/kg body weight thrice a week for 21 days. Another group received equal doses (10 mg/kg body weight) of vitamin B 12 subsequent to NDMA treatment. Animals from either group were sacrificed weekly from the start of the treatment along with their respective controls. Progression of hepatic fibrosis, in addition to the effect of vitamin B 12 , was assessed biochemically for liver function biomarkers, liver glycogen, hydroxyproline (HP) and B 12 reserves along with histopathologically by hematoxylin and eosin (H & E) as well immunohistochemical staining for a-SMA expression. Results and discussion: Elevation in the levels of aminotransferases, SALP, total bilirubin and HP was observed in NDMA treated rats, which was concomitant with remarkable depletion in liver glycogen and B 12 reserves (p50.05). Liver biopsies also demonstrated disrupted lobular architecture, collagen amassing and intense fibrosis by NDMA treatment. Immunohistochemical staining showed the presence of activated stellate cells that was dramatically increased up to day 21 in fibrotic rats. Following vitamin B 12 treatment, liver function biomarkers, glycogen contents and hepatic vitamin B 12 reserves were restored in fibrotic rats, significantly. Vitamin B 12 administration also facilitated restoration of normal liver architecture. Conclusion: These findings provide interesting new evidence in favor of protective role for vitamin B 12 against NDMA-induced hepatic fibrosis in rats.

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“…A study carried out on obese mice showed that tocopherol could protect against NAFLD by reducing liver damage, lipid peroxidation and inflammation, without modifying body mass or hepatic steatosis. The mechanisms by which it acts in patients with NAFLD have yet to be defined (55). − N-acetylcysteine increases glutathione levels in the liver protecting it from oxidative stress.…”

Section: Antioxidants and Cytoprotective Agentsmentioning

confidence: 99%

Pathogenesis, diagnosis and treatment of non-alcoholic fatty liver disease

Martín-Domínguez¹,

González-Casas

Mendoza-Jiménez-Ridruejo

et al. 2013

Rev. esp. enferm. dig.

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Non-alcoholic fatty liver disease (NAFLD) includes a broad spectrum of alterations that go from simple steatosis to steatohepatitis and cirrhosis. Type 2 diabetes mellitus (DM-2) and obesity are the principle factors associated to NAFLD. A 20-30 % prevalence in general population has been described. The survival of this type of patient is lower than the general population's, showing a higher incidence of hepatic and cardiovascular complications. The aetiopathogenesis is still unclear, but we know the intervention of different factors that produce fatty-acid accumulation in hepatic parenchyma, causing oxidative stress, oxygen-free radicals and the synthesis of an inflammatory cascade, that determine the progression of this disease from steatosis up to advanced fibrosis.The diagnostic gold-standard is still the liver biopsy, even though the development of newer non-invasive techniques, like serological and imaging (radiology), have opened a new field for research that allows bloodless testing of these patients and better study of the natural history of this disease. Nowadays, there is still no specific treatment for NAFLD. The development of healthy life habits and moderate exercise continue to be the pillars of treatment. Different pharmacological approaches have been studied and applied, such as the control of insulin resistance, lowering cholesterol levels, antioxidants, and other alternatives in experimental trials.

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Dietary α- and γ-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis

Cited by 70 publications

References 45 publications

Genetic determinants of hepatic steatosis in man

Genetic determinants of hepatic steatosis in man

Vitamin B₁₂supplement alleviatesN′-nitrosodimethylamine-induced hepatic fibrosis in rats

Pathogenesis, diagnosis and treatment of non-alcoholic fatty liver disease

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Dietary α- and γ-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis

Cited by 70 publications

References 45 publications

Genetic determinants of hepatic steatosis in man

Genetic determinants of hepatic steatosis in man

Vitamin B12supplement alleviatesN′-nitrosodimethylamine-induced hepatic fibrosis in rats

Pathogenesis, diagnosis and treatment of non-alcoholic fatty liver disease

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Product

Resources

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Vitamin B₁₂supplement alleviatesN′-nitrosodimethylamine-induced hepatic fibrosis in rats