Antioxidants in Personalized Nutrition and Exercise

Margaritelis, Nikos V.; Paschalis, Vassilis; Theodorou, Anastasios A.; Kyparos, Antonios; Nikolaidis, Michalis G.

doi:10.1093/advances/nmy052

Cited by 63 publications

(66 citation statements)

References 111 publications

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“…Yet, further investigation and critical appraisal of the situations that may warrant vitamin C and E supplementation (i.e., hypovitaminotic cases) in ST are welcome. Of note, recent evidence suggests that antioxidant supplementation can be optimized in exercise contexts when the antioxidant status of each individual is taken into account [53]. Also, the study of different intensities of ST and lower doses of vitamin supplementation combined with the assessment of OS markers and endogenous antioxidant capacity could provide sciencebased information to athletes, coaches, and recreational trainers who want to enhance skeletal muscle adaptations in a long-term basis.…”

Section: Journal Of Sports Medicinementioning

confidence: 99%

The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis

Dutra

Martins

Ribeiro

et al. 2020

Journal of Sports Medicine

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Intense muscle contractile activity can result in reactive oxygen species production in humans. Thus, supplementation of antioxidant vitamins has been used to prevent oxidative stress, enhance performance, and improve muscle mass. In this sense, randomized controlled studies on the effect of vitamin C and E supplementation combined with strength training (ST) on skeletal muscle mass and strength have been conducted. As these studies have come to ambiguous findings, a better understanding of this topic has yet to emerge. The purpose of the present review is to discuss the current knowledge about the effect of vitamin C and E supplementation on muscle mass and strength gains induced by ST. Search for articles was conducted in the following databases: PubMed/Medline, Web of Science, Scopus, Cochrane Central Register of Controlled Trials, and Google Scholar. This work is in line with the recommendations of the PRISMA statement. Eligible studies were placebo-controlled trials with a minimum of four weeks of ST combined with vitamin C and E supplementation. The quality of each included study was evaluated using the Physiotherapy Evidence Database Scale (PEDro). 134 studies were found to be potentially eligible, but only seven were selected to be included in the qualitative synthesis. A meta-analysis of muscle strength was conducted with 3 studies. Findings from these studies indicate that vitamins C and E has no effect on muscle force production after chronic ST. Most of the evidence suggests that this kind of supplementation does not potentiate muscle growth and could possibly attenuate hypertrophy over time.

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Section: Journal Of Sports Medicinementioning

confidence: 99%

The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis

Dutra

Martins

Ribeiro

et al. 2020

Journal of Sports Medicine

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“…For instance, early evidence in human studies suggest that BA supplementation delayed lactate production, but reduce aerobic capacity [21]. Therefore, it is important to investigate if BA or Carnosine supplementation might influences negatively endurance adaptations because of their antioxidant effects [11].…”

Section: Discussionmentioning

confidence: 99%

“…This suggest that other variables (e.g. nutritional status or antioxidant system status) may be influencing this heterogeneity in antioxidant results [11]. For example, no study included in this meta-analysis mentioned that their samples were homogenized for OS or antioxidant status (deficient in oxidant status or not), so future studies with antioxidants supplementation need to homogenize their samples as deficient or not for the antioxidant system [11].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, by identifying these deficiencies in the antioxidant system, supplementation with these substances can help this system to suppress the exacerbate OS induced by PE. Also, future research with BA/carnosine supplementation needs to first check whether its volunteers have antioxidant system deficiencies, as this may affect the rugeness of the study [11].…”

Section: Discussionmentioning

confidence: 99%

“…Recent evidence has suggested that the acute increase in ROS/RNS production during PE is necessary to promote adaptations (e.g., improve athletic performance and VO2max) and the improvement in the antioxidant system itself [9,10]. It is also suggested that the use of exogenous antioxidants may be counterproductive in individuals who already have a balanced oxidant/antioxidant system [11]. However, beta-alanine (BA; a rate-limiting precursor in the synthesis of carnosine) and carnosine supplementation are popular ergogenic aids and also prescribed indiscriminately as antioxidant for athletic population.…”

Section: Introductionmentioning

confidence: 99%

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The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

França¹,

Lira²,

Ruaro³

et al. 2018

Preprint

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The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect BA or carnosine supplementation on Physical exercise (PE)-induced oxidative stress (OS). Before May 2018 we searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young sedentary, recreationally active or athletic participants. After a chronic BA (~30 days) or carnosine (14 days) supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, when compared to placebo, BA/carnosine supplementation increased total antioxidant capacity [TAC; Effect Size (ES) = 0.35, 95% Confidence Interval (CI) 0.06 to 0.65, p = 0.02] and glutathione (GSH; ES = 0.75, 95% CI 0.32 to 1.19, p = 0.0007) concentrations while decreased direct OS markers (ES = −1.19, 95% CI −1.48 to −0.80, p < 0.01) and superoxide dismutase (SOD) activity (ES = −0.58, 95% CI −1.10 to −0.06, p = 0.03). BA or carnosine supplementation did not prevent the increase in indirect OS markers (ES: −0.20, 95% CI −0.59 to 0.20, p = 0.33). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in direct OS species (reactive nitrogen and oxygen species), treatment did not decrease measured values of indirect OS markers (peroxidation or molecule oxidation).

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Correlation analysis between vitamin A, D, and E status with altitude, seasonal variation, and other factors, among children aged 0–6 years in a Chinese population living in the Tibetan plateau of Ganzi prefecture

Huang¹,

Ke²,

Lin³

et al. 2022

Clinical Laboratory Analysis

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Objective We attempted to understand the status of vitamin (Vit) A, D, and E in children aged 0–6 living in the Tibetan plateau areas of Ganzi prefecture, to provide the basis for relevant government departments to carry out physical examinations of these children and to prevent and cure four key diseases (Infantile diarrhea, nutritional anemia, rickets, and infantile pneumonia). Methods Serum retinol and tocopherol levels were detected using high‐performance liquid chromatography (HPLC). Serum levels of 25‐(OH)D were detected by high‐performance liquid chromatography–tandem mass spectrometry (LC–MS). The polynomial logistic regression was used to analyze the effects of age, season, altitude, and gender on Vit A, D, and E levels. Results Vit A and D had the lowest mean serum levels before the age of 1 year and with the most significant deficiency rates. The lowest Vit E levels were seen in the Toddlerhood group. The rates of deficiency and insufficiency were the highest. Vit A, D, and E levels were significantly affected by seasonal changes and were significantly higher in the summer than in any other season. Vit A and D were significantly affected by altitude, and their levels were lowest above 4 km. Conclusion The overall levels of Vit A, D, and E in children aged 0–6 in the Tibetan plateau areas of Ganzi prefecture were lower than those in the plain's areas.

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Antioxidants in Personalized Nutrition and Exercise

Cited by 63 publications

References 111 publications

The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis

The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis

The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

Correlation analysis between vitamin A, D, and E status with altitude, seasonal variation, and other factors, among children aged 0–6 years in a Chinese population living in the Tibetan plateau of Ganzi prefecture

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