Antioxidants in health and disease

Young, Ian S.

doi:10.1136/jcp.54.3.176

Cited by 1,521 publications

(955 citation statements)

References 131 publications

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“…Many antioxidant molecules as mentioned above are found in the blood (Young and Woodside 2001). Individual antioxidants level or activity indicates the antioxidant characteristics of only one antioxidant, whereas TAC may represent the total antioxidant characteristics of all antioxidants found in the serum.…”

Section: Discussionmentioning

confidence: 99%

“…Blood contains many antioxidant molecules which prevent and/or inhibit harmful free radical reactions (Young and Woodside 2001). Paraoxonase (PON) and arylesterase (ARE), located on high-density lipoprotein (HDL), are among the antioxidants and calcium dependent esterase enzymes.…”

Section: Measurement Of the Total Antioxidant Statusmentioning

confidence: 99%

“…The total antioxidant status of the serum was measured using a novel automated colorimetric method and decrease antioxidant levels; on the other hand, antioxidant defense system can protect cells against potentially detrimental effects of oxidant agents (Weiss 1989;Young and Woodside 2001).…”

Section: Measurement Of the Total Antioxidant Statusmentioning

confidence: 99%

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Decreased Total Antioxidant Response and Increased Oxidative Stress in Behcet's Disease

Işık

Koca

Üstündağ

et al. 2007

Tohoku J. Exp. Med.

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Behcet's disease (BD) is a chronic systemic inflammatory disease. Inflammatory reactions trigger the oxidative stress and oxidants decrease the level of antioxidants. In the present study, we aimed to determine serum oxidative/antioxidative status in patients with BD. Serum antioxidative status was evaluated by measuring total antioxidant capacity (TAC), paraoxonase 1, arylesterase, sulfhydryl groups and ceruloplasmin in patients with BD and in healthy controls. Serum oxidative status was evaluated by measuring total peroxide (TP), lipid hydroperoxides and oxidative stress index (OSI). OSI was calculated by percent ratio of TP to TAC. Serum levels of TAC, sulfhydryl groups and activities of paraoxonase 1, arylesterase, and ceruloplasmin were significantly lower in patients than in controls ( p < 0.001 for all). In contrast, TP, lipid hydroperoxides and OSI values were significantly higher in patients than in controls ( p < 0.001 for all). Further, the level of TAC was negatively correlated with the levels of TP, lipid hydroperoxides and OSI both in the BD (r = −0.578, p < 0.01; r = −0.559, p < 0.01 and r = −0.552, p < 0.01, respectively) and the control groups (r = −0.469, p < 0.05; r = −0.351, p < 0.05 and r = −0.391, p < 0.05, respectively). These results indicate that the oxidant parameters increased and antioxidant parameters decreased in patients with BD; therefore, these patients might have been exposed to oxidative stress. We suggest that impaired oxidant/ antioxidant balance should be taken into consideration in the follow-up of patients with BD.

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Section: Discussionmentioning

confidence: 99%

Section: Measurement Of the Total Antioxidant Statusmentioning

confidence: 99%

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Decreased Total Antioxidant Response and Increased Oxidative Stress in Behcet's Disease

Işık

Koca

Üstündağ

et al. 2007

Tohoku J. Exp. Med.

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“…The oxidative stress implicated in the pathology of a number of disorders, such as atherosclerosis, ischemia-reperfusion injury, cancer, malaria, diabetes, inflammatory joint disease, asthma, cardiovascular diseases, cataracts, immune system decline, play a role in neurodegenerative diseases and aging processes (Young and Woodside 2001). Furthermore, nanoparticles are also shown to cause toxicity by increasing concentration of intracellular ROS and decrease in antioxidant level (Singh et al 2009;Hussain et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Toxicity assessment on haemotology, biochemical and histopathological alterations of silver nanoparticles-exposed freshwater fish Labeo rohita

2015

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The increasing use of nano based-products induces the potential hazards from their manufacture, transportation, waste disposal and management processes. In this report, we emphasized the acute toxicity of silver nanoparticles (AgNPs) using freshwater fish Labeo rohita as an aquatic animal model. The AgNPs were synthesized using chemical reduction method and the formation of AgNPs was monitored by UV-Visible spectroscopy analysis. The functional groups, crystaline nature and morphological characterizations were carried out by fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and high resolution transmission electron microscopy (HRTEM) analysis. UV-Vis range was observed at 420 nm and XRD pattern showed that the particles are crystalline nature. HRTEM analysis revealed that the morphology of particles was spherical and size ranges between 50 and 100 nm. This investigation was extended to determine the potential acute toxicity, L. rohita was treated orally with the lethal concentration (LC 50 ) of AgNPs. The antioxidative responses were studied in the three major tissues such as gill, liver and muscle of L. rohita. The results of this investigation showed that increasing the concentration of AgNPs led to bioaccumulation of AgNPs in the major tissues. The haematological parameters showed significant alterations in the treated fish. The histological changes caused by chemically synthesized AgNPs demonstrated the damages in the tissues, primary lamella and blood vessels of L. rohita. The histological study also displayed the formation of vacuolation in liver and muscle when compared with untreated tissues (control) of L. rohita.

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“…A number of enzymes are known to have major antioxidant activity, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione reductase (GR). Antioxidants can be defined as any substance that when present at low concentrations compared to that of an oxidizable substrate, significantly delays or inhibits the oxidation of that substrate [11,12]. Therefore SOD detoxified O 2 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Acetaminophen Effect on Oxidative Stressed Mice by Peroxide Hydrogen

Zoubair¹,

Azzahra²,

Hmimid³

et al. 2013

AJBR

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Acetaminophen (Paracetamol) is among the most commonly used analgesic and antipyretic drugs worldwide, it's often, but anomalously, classified as non-steroidal anti-inflammatory drugs (NSAIDs) in textbooks of pharmacology [1,2]. This study aims to evaluate if paracetamol has an antioxidant effect, relative to its analgesic antipyretic and weak anti-inflammatory activities, or it possesses a cytotoxic potential. Oxidative stress was induced by intraperetoneal injection of peroxide hydrogen (H 2 O 2 ), and then a comparative study is made concerning the activities of the antioxidant enzymes SOD, CAT, and GR as well as lipid peroxidation levels in liver. An increase in SOD, CAT, GR activity and lipid peroxidation in mice treated with H 2 O 2 accompanied by paracetamol; compared to the group treated by vitamin C + H 2 O 2 showed that acetaminophen doesn't show any antioxidant effect. Moreover this study has suggested that acetaminophen induced cytotoxicity in liver mediated by increased oxidative stress and altered redox metabolism. Keywords: acetaminophen (paracetamol), peroxide hydrogen, oxidative stressCite This Article: BENKHASSI Zoubair, LAHLOU Fatima Azzahra, HMIMID Fouzia, LOUTFI Mohammed, BENAJI Brahim, and BOURHIM Noureddine, "Evaluation of Acetaminophen Effect on Oxidative Stressed Mice by Peroxide Hydrogen

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Antioxidants in health and disease

Cited by 1,521 publications

References 131 publications

Decreased Total Antioxidant Response and Increased Oxidative Stress in Behcet's Disease

Decreased Total Antioxidant Response and Increased Oxidative Stress in Behcet's Disease

Toxicity assessment on haemotology, biochemical and histopathological alterations of silver nanoparticles-exposed freshwater fish Labeo rohita

Evaluation of Acetaminophen Effect on Oxidative Stressed Mice by Peroxide Hydrogen

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