Antioxidants in dermocosmetology: from the laboratory to clinical application

Abstract

Oxygen situated in cutaneous cells can be activated by light. This makes the integumentary apparatus particularly vulnerable to oxidative damage and is responsible for the immediate cutaneous damage that is the basis of late phenomena, such as photo-induced ageing and tumours. Thus, the cosmetic industry has undertaken research and development into antioxidant-based products able to protect the skin from the effect of pro-oxidizing noxae. This review re-examines both antioxidants suitable for dermatological application and skin care products with antioxidant capacity, as well as the laboratory methods used to evaluate the effects and in vivo efficacy of antioxidants.

Chemoprevention of photocarcinogenesis by lycopene

“…reviews , a positive association between lycopene intake and a prevention of UV‐induced erythema formation and a decreased risk of non‐melanoma skin cancer were reported, respectively. Andreassi has also reviewed studies on humans demonstrating that lycopene is able to protect the skin from the effects of UV‐B rays, especially when associated with vitamins C and E, supporting some results obtained in in vitro studies already mentioned. These protective effects have been attributed to redox reactions of carotenoids that may influence UVR carcinogenesis .…”

“…Andreassi has also reviewed (51) studies on humans demonstrating that lycopene is able to protect the skin from the effects of UV-B rays, especially when associated with vitamins C and E, supporting some results obtained in in vitro studies already mentioned. These protective effects have been attributed to redox reactions of carotenoids that may influence UVR carcinogenesis (51). Other investigators (52,53) have recently demonstrated that lycopene is also be able to reduce photoaged skin.…”

Discovery of oxathiapiprolin, a new oomycete fungicide that targets an oxysterol binding protein

“…13,14 A biochemical approach used a tethered version of isoxazoline 13 to isolate binding proteins by affinity chromatography. One of these was identified by mass spectrometry as an oxysterol binding protein (OSBP).…”

Potential of antioxidant extracts produced by aqueous processing of renewable resources for the formulation of cosmetics

“…The reactive species used in this assays is representative for skin oxidative stress processes (Andreassi and Andreassi, 2004;Polefka et al, 2012). The IC 50 values were 200 µg/mL for the winery byproducts concentrated extract, 1000 for extracts from hydrothermal treatments and 5000 for ethanolic extracts from S. muticum.…”