Antioxidants: Are We abusing It?

Shrihari, T G; Vasudevan, Vijeev; Kailasam, S; Devaraju, D; Manjunath, V; Jagadish, GR

doi:10.5005/jp-journals-10011-1319

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…The anti-inflammatory property of Cp could have brought down the burning sensation in the mouth and diminished appearance of oral cancerous lesions in Group 1 patients than Group 2 patients [2,27,28]. Thus even though quitting betel quid chewing remains the treatment of choice for premalignant oral lesions, there is a role for antioxidants in the treatment provided they are used and monitored with caution [29].…”

Section: Discussionmentioning

confidence: 99%

A Cytogenetic Study on the Efficacy of Chyawanprash Awaleha as an Antioxidant in Oral Premalignant Cancer

Uma

Kotasthane

2014

Journal of Oral Oncology

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Background. Chyawanprash awaleha (Cp) is an Ayurvedic rasayana formulation and is used as a genoprotective agent.Objective. The present cytogenetic study has been done to investigate the efficacy of Cp against betel quid chewers suffering from oral precancerous lesions through satellite association (SA) assay.Materials and Methods. The frequency of SA was analyzed in 21 betel quid chewing oral precancerous lesions patients and then they were divided into 2 groups. Group 1 consisted of 15 patients, advised to quit betel quid chewing and fed with 20 gms of Cp, twice a day for three months. Group 2 consisted of 6 patients, who refused Cp feed but accepted to quit betel quid chewing. At the end of three months, both groups were assessed cytogenetically.Results. The frequency of SA was statistically significant in both groups, but an elevated mean difference was observed more in Group 1 than in Group 2.Conclusion. The study indicates that betel quid cessation reduces the effect of DNA damage in oral precancerous lesions. But the increased mean difference in SA in Group 1 compared to Group 2 clearly indicates that Cp can further minimize the genotoxic effect caused by mutagenic agents present in betel quid.

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Section: Discussionmentioning

confidence: 99%

A Cytogenetic Study on the Efficacy of Chyawanprash Awaleha as an Antioxidant in Oral Premalignant Cancer

Uma

Kotasthane

2014

Journal of Oral Oncology

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“…It has an anti-inflammatory property by down regulating keytranscription factors of inflammation are NF-KB and STAT-3 mediated regulation of IL-1, IL-6, IL-8, TNF-α, 5-LOX, CXCR-4,COX-2, iNOS proinflammatory genes involved in various inflammatory reactions and cancer. 2,6 Daily recommended dosages: 3mg/kg body weight. 0.5gm and 7.5gm curcumin/daydivided into 3-4 even doses.…”

Section: Anti-inflammatory Dietary Supplements In Prevention Of Diseamentioning

confidence: 99%

Anti-inflammatory dietary supplements in prevention of diseases in geriatric people

Singh

2019

Int J Adv Med

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As our age advances, many changes are seen in our body, such as cellular changes, cardiovascular problems, cerebrovascular diseases, including cancer mediated by inflammation and their mediators such as free radicals (ROS, RNS), cytokines, transcription factors (NF-KB, STAT3) due to altered dietary patterns and digestive disorders. The disease pattern can be suppressed by including anti-inflammatory dietary supplements in our diet to prevent various diseases in geriatric peoples associated with inflammation. Chronic activation of the inflammatory response, defined as inflammation, is the key physio-pathological substrate for anabolic resistance, sarcopenia and frailty in older individuals. Nutrients can theoretically modulate this phenomenon. This article briefs about anti-inflammatory dietary supplements in prevention of diseases associated with inflammation in geriatric people.

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“…And, 25% of cancers are preceded by chronic inflammation such as oral cancer associated with oral potentially malignant lesions and conditions, Crohn's diseases, Prostate cancer, Breast cancer, cervical cancer, and Head and Neck cancer. Chronic inflammation is also considered as seventh hallmark of cancer [1][2][3][4][5]. They have an anti-inflammatory role and CRP(C-reactive protein) level reduction related to strain specific such as Lactobacillus, Bifidobacterium, Saccharomyces, Enterococcus, and E. coli.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Dietary Supplements in Prevention of Diseases

Tg¹

2018

GGS

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Anti-inflammatory dietary supplements in prevention of diseases in geriatric peopleGeriatric patients are prone to many diseases because of altered dietary patterns, reduced immune activity, altered cell proliferation and regeneration, muscle wasting, altered digestive pattern, and bone changes that lead to various complications.Inflammation is preceded by most of all diseases. Hence, our aim is to suppress the inflammation by dietary supplements to prevent diseases for better health of an individual in geriatric peoples. Anti-inflammatory dietary supplements present in the food are Vitamin A, Vitamin C, vitamin E, Omega 3 fatty acids, Vitamin D, probiotics, curcumin [2]. Curcumin is apolyphenol, active component of Turmeric, extracted from the dried Rhizome of the Curcuma Longa plant. It has an anti-inflammatory property by down regulating key transcription factors of inflammation are NF-KB and STAT-3 mediated regulation of IL-1, IL-6, IL-8, TNF-α, 5-LOX, CXCR-4,COX-2, iNOS pro -inflammatory genes involved in various inflammatory reactions and cancer [2,6]. Daily recommended dosages: 3mg/kg body weight. 0.5gm and 7.5gm Curcumin/day-divided into 3-4 even doses. Sources: Made from the Rhizomes of the plant Curcuma Longa. Vitamin A, Vitamin C, Vitamin E are a vitamin, which neutralize the release of free radicals such as ROS, and RNS involved in oxidative stress induced cytokine activation and transcription factor that promotes DNA damage, cell aging, and cell death. They prevent the cell aging and cell death by reduction of inflammation associated with inflammatory conditions and cancer [1,9,10]. Daily recommended dosage of vitamin A is 900mg/day. Sources: Diary products, fish, dark chocolate's, fruits and vegetables such as tomatoes and papaya. Daily recommended dosage of Vitamin C is 90mg/day. Sources: Citrus fruits such as orange, peppers, Dark leafy vegetables, Tomatoes, Broccoli, Papaya, Green peas. Daily recommended dosage of Vitamin E is 14-15mg/day [22.5 IU].

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Antioxidants: Are We abusing It?

Cited by 5 publications

References 21 publications

A Cytogenetic Study on the Efficacy of Chyawanprash Awaleha as an Antioxidant in Oral Premalignant Cancer

A Cytogenetic Study on the Efficacy of Chyawanprash Awaleha as an Antioxidant in Oral Premalignant Cancer

Anti-inflammatory dietary supplements in prevention of diseases in geriatric people

Anti-Inflammatory Dietary Supplements in Prevention of Diseases

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