Antioxidants and Electrolyte Profile in Early Pregnancy: In vivo Studies

Iribhogbe, Osede Ignis; Akpamu, U; Emordi, J.E.; Aigbiremol, A.; Nwoke, E.O.; Idinoje, B.

doi:10.3923/ajbmb.2011.82.88

Cited by 5 publications

(2 citation statements)

References 3 publications

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“…TG gains extraordinary position among other parameters as hypertriglyceridemia directly associated with PIH as described in early studies. Estrogen modulates hypertriglyceridemia mainly by hepatic synthesis of triglycerides and higher TG affects endothelial through generation of LDL and VLDL during hypertensive pregnancy status [2,13,[15][16][17][18][19]. During hypertensive phase of pregnancy free fatty acids especially linolenic acid and TG concentrations are detected higher in blood.…”

Section: Discussionmentioning

confidence: 99%

Hypo-magnesium and Hyperlipidemia Responsible for Hypertensive Status of Pregnant Women in Pakistani Population

Parveen

Farooq

Arshad

et al. 2020

JPRI

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Background/ Aim: Pregnancy induced hypertension (PIH) has been a leading cause of maternal mortality worldwide. It could be responsible for several complications like hemodilution, altered lipid metabolism and deficiencies of different minerals in body. Although the causes of Pregnancy induced hypertension (PIH) remains indistinct. The aim of our present study was to evaluate the changes in magnesium serum levels and lipid profile in hypertensive and normotensive pregnant women. Materials and Methods: An analytical case control study comprising 60 individuals was designed. From which 30 normotensive pregnant women served as control group (A) and 30 pregnancy induced hypertensive women served as case group (B). Patients with pre-existing hypertension were excluded. Results: The independent t-test was used for comparison of various parameters between group A and B. Triacylglycerol (TAG) and low density lipoprotein cholesterol (LDL-C) levels were significantly high in PIH (B) as compare to normotensive group (A). Mean serum values of TG were measured as (195.73 ± 70.28 vs 156.27 ± 55.60 mg dL-1) and LDL-C vs control (87.33 ± 37.74 vs 69.45 ± 28.58 mg dL-1) in PIH and normotensive groups respectively. HDL-C in PIH vs Control (47.40±1.12 vs 54.43 ±1.27 mg dL-1) and Mg+2 PIH vs control (1.36±0.07 vs 1.94±0.35 mg dL-1) were measured respectively. High density lipoprotein cholesterol (HDL-C) and magnesium Mg+2 levels were significantly reduced in PIH. Conclusion: The lower serum magnesium levels and abnormal lipids profile may indicate their possible role as risk factors in the development of PIH in pregnant women. Hence initial diagnosis of hypomagnesemia in PIH cases may help in minimizing the complications and development of new cure strategies.

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Section: Discussionmentioning

confidence: 99%

Hypo-magnesium and Hyperlipidemia Responsible for Hypertensive Status of Pregnant Women in Pakistani Population

Parveen

Farooq

Arshad

et al. 2020

JPRI

View full text Add to dashboard Cite

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“…Hypertension, defined by a blood pressure (BP) of 140/90 mm Hg or more, is a universal problem affecting at least 10% of all pregnancies. 1 Half of the pregnant women with hypertension have pre-eclampsia. Hypertensive disorders accounts for up to 40,000 maternal deaths annually.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Serum Calcium and Magnesium in Pre-eclamptic Pregnancies in Third Trimester and its Comparison with Healthy Normotensive Nonpregnant and Pregnant Women and to Evaluate their role in Pregnancy-induced Hypertension

Varma¹,

Sogani²,

Sarkar³

2015

MGM Journal of Medical Sciences

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Background: Despite numerous studies, the etiology of pre eclampsia has not been fully elucidated. The study of serum calcium and serum magnesium is gaining ground in the patho physiology of hypertension.Objective: A comparative study of serum calcium and serum magnesium in women with preeclamptic pregnancy and its comparison with healthy normotensive nonpregnant women and healthy normotensive pregnant women in third trimester. Materials and methods:Serum calcium and serum magnesium were measured in 52 women with preeclampsia in their trimester of pregnancy as patients group, and in 73 healthy normotensive nonpregnant women and 65 healthy normotensive pregnant women as control groups with similar maternal and gestational ages. Preeclamptic group was further divided into two subgroups mild (n = 36) and severe preeclampsia (n = 16). This is the casecontrol hospital based study carried in the Department of Biochemistry, MGM Medical College and associated MY Hospital, Indore, Madhya Pradesh.Results: There were no significant differences among the three groups in age and body mass index (BMI) (p > 0.05) but significantly higher differences in gestational age, systolic and diastolic blood pressure was observed (p < 0.001). When com parison of serum calcium and serum magnesium between healthy normotensive nonpregnant women (9.87 ± 0.6 mg/dl, 2.60 ± 0.3 mg/dl) and healthy normotensive pregnant women was done, the levels were lower in the healthy normotensive preg nant women (9.34 ± 0.49 mg/dl, 2.36 ± 0.13 mg/dl) with sta tistically higher significant difference (p < 0.001). Lower mean values of serum calcium and serum magnesium were found in preeclamptic women (8.82 ± 0.93 mg/dl, 1.74 ± 0.24 mg/dl) than those of healthy normotensive nonpregnant women (9.87 ± 0.6 mg/dl, 2.60 ± 0.3 mg/dl) and healthy normotensive pregnant women (9.34 ± 0.49 mg/dl, 2.36 ± 0.13 mg/dl) in third trimester with statistically higher significant differences (p < 0.001). As compare to mild preeclamptic pregnant women (9.07 ± 0.8 mg/ dl, 1.77 ± 0.24 mg/dl), the levels of serum calcium and serum magnesium in severe preeclamptic pregnant women (8.25 ± 0.97 mg/dl 1.65 ± 0.24 mg/dl) was lower and the difference was significantly higher (p < 0.001). Conclusion:These findings support the hypothesis that hypo calcemia and hypomagnesemia are possible etiologies of preeclampsia and levels of calcium may be more important than magnesium.

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Physiological Response of West African Dwarf Goats to Oral Supplementation with Omega-3-fatty Acid

Okukpe¹,

Adeloye²,

Yousuf³

et al. 2011

Asian J. of Animal Sciences

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Antioxidants and Electrolyte Profile in Early Pregnancy: In vivo Studies

Cited by 5 publications

References 3 publications

Hypo-magnesium and Hyperlipidemia Responsible for Hypertensive Status of Pregnant Women in Pakistani Population

Hypo-magnesium and Hyperlipidemia Responsible for Hypertensive Status of Pregnant Women in Pakistani Population

Comparative Study of Serum Calcium and Magnesium in Pre-eclamptic Pregnancies in Third Trimester and its Comparison with Healthy Normotensive Nonpregnant and Pregnant Women and to Evaluate their role in Pregnancy-induced Hypertension

Physiological Response of West African Dwarf Goats to Oral Supplementation with Omega-3-fatty Acid

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