Antioxidant, α-Amylase and α-Glucosidase Inhibitory Activities and Potential Constituents of Canarium tramdenum Bark

Quan, Nguyen Van; Xuan, Tran Dang; Tran, Hoang-Dung; Thúy, Nguyễn Thị Diệu; Trang, Le Thu; Huong, Can Thu; Andriana, Yusuf; Tuyen, Phung Thi

doi:10.3390/molecules24030605

Cited by 90 publications

(69 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The antioxidant capacities of MA, MB, and the mixture of MA and MB (MAB, 1:1, v/v) were evaluated and compared with tricin by 2,2'-azino-bis radical cation (ABTS•+) decolorization, reducing power, and β-carotene bleaching methods which were described previously by Quan et al [17].…”

Section: Antioxidant Activitiesmentioning

confidence: 99%

Momilactones A, B, and Tricin in Rice Grain and By-Products are Potential Skin Aging Inhibitors

Quan

Thien²,

Khanh

et al. 2019

Foods

Self Cite

View full text Add to dashboard Cite

We previously reported the inhibitory potentials of momilactones A (MA) and B (MB) against key enzymes related to type 2 diabetes and obesity. In this study, antioxidant and anti-skin-aging activities of MA and MB were investigated and compared with tricin, a well-known antioxidant and antiaging flavonoid in rice. MA, MB, and tricin were purified from rice husk by column chromatography and their biological activities were subsequently assayed by in vitro trials. The contents of MA, MB, and tricin of different commercial rice cultivars in Japan were quantified and confirmed by ultra-performance liquid chromatography-electrospray ionization-mass spectrometry (UPLC-ESI-MS) and high-performance liquid chromatography (HPLC) analyses. The antioxidant assays revealed a synergistic activity of the mixture MA and MB (MAB, 1:1, v/v). In addition, in 2,2'-azino-bis (ABTS) assay, IC 50 values of MAB (0.3 mg/mL) and tricin (0.3 mg/mL) was 4-fold and 9-fold greater than that of individual MB (1.3 mg/mL) or MA (2.8 mg/mL), respectively. The in vitro enzymatic assays on pancreatic elastase and tyrosinase indicated that MA and MB were potential to relief skin wrinkles and freckles. In detail, MA exerted higher inhibition on both enzymatic activities (30.9 and 37.6% for elastase and tyrosinase inhibition, respectively) than MB (18.5 and 12.6%) and MAB (32.0 and 19.7%) at a concentration of 2.0 mg/mL. Notably, MA and the mixture MAB exhibited stronger inhibitions on elastase and tyrosinase in comparison with tricin and vanillin. MA, MB, and tricin in rice are potential to develop cosmetics as well as supplements for skin aging treatments.

show abstract

Section: Antioxidant Activitiesmentioning

confidence: 99%

Momilactones A, B, and Tricin in Rice Grain and By-Products are Potential Skin Aging Inhibitors

Quan

Thien²,

Khanh

et al. 2019

Foods

Self Cite

View full text Add to dashboard Cite

show abstract

“…In this research, the DPPH and ABTS assays were conducted to evaluate the antioxidant activities of the samples. The antioxidant property is mainly characterized by phenolic contents that can effortlessly naturalize free radicals [11]. We found that K2 had higher antioxidant activity in both grain and straw than the original cultivar.…”

Section: Discussionmentioning

confidence: 79%

“…The phenolic contents were also increased with the antioxidant activities. Quan et al [11] assumed that phenolics might not be the only contributors toward the antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

“…DPPH assay was carried out based on the method explained by Quan et al [11] with few adjustments. Shortly, 50 µL of the sample extract was added with 50 µL of DPPH solution (500 µM in methanol) and 100 µL of 0.1 M acetate buffer (pH 5.5).…”

Section: Dpph Scavenging Assaymentioning

confidence: 99%

“…Additionally, bioactive compounds including antioxidants, phenolics, and momilactones play important roles in human health, pharmaceutical industries, and allelopathy [4,11,12]. Antioxidants effectively inhibit and neutralize free radical reactions by providing hydrogen or electron to the reaction chain [13].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of N-Methyl-N-Nitrosourea Mutation on Physicochemical Properties, Phytochemicals, and Momilactones A and B in Rice

et al. 2019

Self Cite

View full text Add to dashboard Cite

Attempts regarding the improvement and development of novel rice with better quality and higher productivity have been increasing. Among approaches, mutation is a direct alteration on the genome and considered as one of the most beneficial routes to acquire new beneficial traits in rice. An experiment was carried out to explore the effects of N-methyl-N-nitrosourea (MNU) mutation on the antioxidant activities, phytochemical compounds, and momilactones A (MA) and B (MB) in rice. Two rice cultivars, K1 (an original cultivar DT84) and K2 (mutated DT84), were examined. Antioxidant activities, phenolic compounds, and momilactones of the rice grain, husk, and straw portions were measured and quantified. Antioxidant activities were higher in grain and straw of K2, whereas K1 showed greater antioxidant activity in rice husk. Additionally, K2 displayed higher total phenolic contents (TPC) in grain and straw as well as lower of it in the husk, but these variations significantly differed only in the straw portion. An increase in total flavonoid contents (TFC) was observed in the husk of K1, while K2 significantly enhanced TFC in straw. Both MA and MB, two compounds obtaining antidiabetes, anticancer, antimicrobial, antigout, and antiobesity properties, were detected and quantified in grain, husk, and straw of K1 and K2 samples. Generally, the contents of MA were higher than MB in all tested portions of rice crop. MA and MB were higher in straw followed by those in husk and grain, respectively. K2 contained higher amounts of MA and MB in straw and husk, but lower contents in grain compared with those in K1. This study illustrates that MNU mutation can improve grain quality and enhance bioactive compounds in straw, husk, and grain of rice. This approach has the potential to develop functional foods from rice, and therefore help farmers in developing countries to improve value in rice production.

show abstract

Therapeutic properties, biological effects, antiliver cancer, and anticolon cancer effects of some natural compounds: A biochemical approach

Li,

Zhu,

Huang

et al. 2023

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Natural compounds, such as carotenoids, flavonoids, anthocyanins, or terpenoids, are physiologically active components found in plants (pigments), often known as phytochemicals or phytonutrients. The in vitro cytotoxic and anticolon cancer effects of biologically bavachin, bavachinin, artepillin C, and aromadendrin compounds against SW48, SNU‐C1, COLO 205, RKO, LS411N, and SW1417 cancer cell lines were assessed. Results of enzymes and antibacterial, antifungal were in level of micromolar that is good impacts. These natural compounds may be antidiabetic, anticancer, and antibacterial candidates for drug design. IC50 results were obtained between 14–19 and 5–119 µM for α‐amylase and α‐glucosidase, respectively. Good inhibitor Bavachinin was detected for both enzymes (IC50 for α‐amylase: 14.37 µM and IC50 for α‐glucosidase: 5.27 µM). The chemical activities of aromadendrin, artepillin C, bavachin, and bavachinin against pancreatic α‐amylase and α‐glucosidase were assessed by conducting the molecular docking study. The chemical activities of aromadendrin, artepillin C, bavachin, and bavachinin against some of the expressed surface receptor proteins (CD44, CD47, CXCR4, EGFR, folate receptor, HER2, and endothelin receptor) in the mentioned cell lines were investigated using the molecular docking calculations. The results illustrated the atomic‐level properties and potential interactions. These chemicals have high binding affinities to the enzymes and proteins, according to the docking scores. In addition, the compounds formed strong contacts with the enzymes and receptors. Thus, these compounds could be potential inhibitors for enzymes and cancer cells.

show abstract

Antioxidant, α-Amylase and α-Glucosidase Inhibitory Activities and Potential Constituents of Canarium tramdenum Bark

Cited by 90 publications

References 46 publications

Momilactones A, B, and Tricin in Rice Grain and By-Products are Potential Skin Aging Inhibitors

Momilactones A, B, and Tricin in Rice Grain and By-Products are Potential Skin Aging Inhibitors

Efficacy of N-Methyl-N-Nitrosourea Mutation on Physicochemical Properties, Phytochemicals, and Momilactones A and B in Rice

Therapeutic properties, biological effects, antiliver cancer, and anticolon cancer effects of some natural compounds: A biochemical approach

Contact Info

Product

Resources

About