Antioxidant Stress and Anti-Inflammation of PPARαon Warm Hepatic Ischemia-Reperfusion Injury

Abstract

Hepatic ischemia-reperfusion (IR) injury is a serious clinical problem. Minimizing the adverse effect of ischemia-reperfusion injury after liver surgery or trauma is an urgent need. It has been proved that besides the effect of regulating the lipid and lipoprotein metabolism, PPARα also undertakes the task of organ protection. In this paper, related literature has been summarized and we come to the conclusion that administration of PPARα agonists can strengthen the antioxidant and anti-inflammation defense system by the upregulation of the expression of antioxidant enzymes and inhibition of NF-κB activity. This may provide a potential clinical treatment for hepatic ischemia-reperfusion injury.

Hippocampal PPARα is a novel therapeutic target for depression and mediates the antidepressant actions of fluoxetine in mice

“…PPARα is a promising therapeutic target for several neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, Huntington disease and amyotrophic lateral sclerosis (Agarwal et al ., 2017; Barbiero et al ., ; D'Orio et al ., ). PPARα activation significantly decreased neuronal death in models of cerebral ischaemia reperfusion and also improved the learning and memory of rodents (Gao and Li, ; Roy et al ., ; Roy et al ., ; Xuan et al ., ). PPARα has been closely implicated in oxidative stress, neuroinflammation, neurogenesis and synaptic plasticity (Gao and Li, ; Roy et al ., ; Fidaleo et al ., ; Pérez‐Martín et al ., ).…”

“…PPARα activation significantly decreased neuronal death in models of cerebral ischaemia reperfusion and also improved the learning and memory of rodents (Gao and Li, ; Roy et al ., ; Roy et al ., ; Xuan et al ., ). PPARα has been closely implicated in oxidative stress, neuroinflammation, neurogenesis and synaptic plasticity (Gao and Li, ; Roy et al ., ; Fidaleo et al ., ; Pérez‐Martín et al ., ). This study provides another aspect of PPARα function.…”

“…Recently, PPARα has been found to be involved in the CNS besides in fatty acid catabolism. PPARα can modulate antioxidant responses, neurotransmission, neuroinflammation, neurogenesis (Gao and Li, ; Fidaleo et al ., ; Esmaeili et al ., ; Pérez‐Martín et al ., ). Roy et al .…”

Shinzami Korean purple‐fleshed sweet potato extract prevents ischaemia–reperfusion‐induced liver damage in rats

“…In the initial phase of an I/R injury, Kupffer cells are activated and produce reactive oxygen free radicals . These free radicals and ROS disrupt cellular homeostasis and cause mitochondrial dysfunction in adjacent hepatocytes . The formation of free radicals may initiate a cascade of cell damage and necrosis/apoptosis .…”

“…20 These free radicals and ROS disrupt cellular homeostasis and cause mitochondrial dysfunction in adjacent hepatocytes. 21 The formation of free radicals may initiate a cascade of cell damage and necrosis/apoptosis. 22 An accumulation of ROS results in intense necrotic death of cells.…”