Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice

Fan, Songtao; Huang, Xiao‐Jun; Wang, Sunan; Li, Chang; Xie, Mingyong; Nie, Shaoping

doi:10.1016/j.fct.2018.05.027

Cited by 28 publications

(5 citation statements)

References 41 publications

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“…MDA is the final product of lipid peroxidation and thus is the most representative product of lipid peroxidation in cells. MDA levels can directly reflect the degree of lipid peroxidation and indirectly reflect the degree of reaction of free radicals [31]. The results revealed that 1‐[( R )‐ethylsulfinyl]sulfanylethane indirectly promoted the production of MDA, indicating that the cells were damaged by oxygen free radicals.…”

Section: Discussionmentioning

confidence: 97%

Antifungal activity of an allicin derivative against Penicillium expansum via induction of oxidative stress

Ding

Tang

et al. 2020

J Basic Microbiol

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The application of natural preservatives has become an attractive method for controlling postharvest decay of fruits and vegetables. Allicin, the main active ingredient of allium plants, has broad‐spectrum antifungal activity. However, the unstable properties of allicin limit its wide application. In this study, 1‐[(R)‐ethylsulfinyl]sulfanylethane, a structurally stable derivative of allicin, was used to explore its antifungal activity and potential mechanism on the expansion of Penicillium expansum. We demonstrated the antifungal activity of 1‐[(R)‐ethylsulfinyl]sulfanylethane through in vitro antifungal experiments. At the concentration is 2 mg/L, 1‐[((R)‐ethylsulfinyl]sulfanyl]ethane can completely inhibit spore germination and mycelial growth, whereas the concentration of allicin needs to reach 16 mg/L. Fungal Biochemical assay indicated that decrease of mitochondrial membrane potential, overgeneration of reactive oxygen species, decrease of adenosine triphosphate and glutathione content, increase of superoxide dismutase, catalase, and malondialdehyde content. The results revealed that 1‐[(R)‐ethylsulfinyl]sulfanylethane induced mitochondrial dysfunction and oxidative stress in P. expansum. Due to its excellent antifungal activity, 1‐[((R)‐ethylsulfinyl]sulfanyl]ethane might be developed as a substitute for fungicides against P. expansum in postharvest fruit storage.

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Section: Discussionmentioning

confidence: 97%

Antifungal activity of an allicin derivative against Penicillium expansum via induction of oxidative stress

Ding

Tang

et al. 2020

J Basic Microbiol

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“…In addition to the more researched fungi reviewed above, there are also other polysaccharides from Hericium erinaceus [ 95 ], Cordyceps sinensis , and Ganoderma atrum [ 96 , 97 ] that have good antioxidant activities. Activating antioxidant enzyme activity prevents mitochondrial-dependent apoptosis and plays a regulatory and protective role in colonic immune disorder and hepatotoxicity.…”

Section: Antioxidant Activity Of Natural Polysaccharidesmentioning

confidence: 99%

Antioxidant Activities of Natural Polysaccharides and Their Derivatives for Biomedical and Medicinal Applications

Bai

Zhou

et al. 2022

Antioxidants

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Many chronic diseases such as Alzheimer’s disease, diabetes, and cardiovascular diseases are closely related to in vivo oxidative stress caused by excessive reactive oxygen species (ROS). Natural polysaccharides, as a kind of biomacromolecule with good biocompatibility, have been widely used in biomedical and medicinal applications due to their superior antioxidant properties. In this review, scientometric analysis of the highly cited papers in the Web of Science (WOS) database finds that antioxidant activity is the most widely studied and popular among pharmacological effects of natural polysaccharides. The antioxidant mechanisms of natural polysaccharides mainly contain the regulation of signal transduction pathways, the activation of enzymes, and the scavenging of free radicals. We continuously discuss the antioxidant activities of natural polysaccharides and their derivatives. At the same time, we summarize their applications in the field of pharmaceutics/drug delivery, tissue engineering, and antimicrobial food additives/packaging materials. Overall, this review provides up-to-date information for the further development and application of natural polysaccharides with antioxidant activities.

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“…Cordyceps militaris is an entomopathogenic filamentous fungus, belonging to division Ascomycota, class Sordariomycetes, order Hypocreales, family Clavicipitaceae. C. militaris has been demonstrated to be beneficial in the treatment of male reproductive problems (Chen et al, 2017), chronic kidney (Zhang et al, 2014;Hong et al, 2015), respiratory (Bai et al, 2020), heart, liver (Cheng et al, 2014;Liu et al, 2014;Fan et al, 2018) and lung diseases (Wang et al, 2016), hyperglycemia, hyperlipidemia, and cancer. Wild C. militaris is generally called Yong Chong Cao in China for its parasitizing within the insect host's body in winter and forming grass-like fruiting bodies by absorbing nutrients from host's body in summer.…”

Section: Introductionmentioning

confidence: 99%

New Insights Into the Biosynthesis of Typical Bioactive Components in the Traditional Chinese Medicinal Fungus Cordyceps militaris

Huang

et al. 2021

Front. Bioeng. Biotechnol.

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Cordyceps militaris, a traditional medicinal ingredient with a long history of application in China, is regarded as a high-value fungus due to its production of various bioactive ingredients with a wide range of pharmacological effects in clinical treatment. Several typical bioactive ingredients, such as cordycepin, D-mannitol, cordyceps polysaccharides, and N6-(2-hydroxyethyl)-adenosine (HEA), have received increasing attention due to their antitumor, antioxidant, antidiabetic, radioprotective, antiviral and immunomodulatory activities. Here, we systematically sorted out the latest research progress on the chemical characteristics, biosynthetic gene clusters and pathways of these four typical bioactive ingredients. This summary will lay a foundation for obtaining low-cost and high-quality bioactive ingredients in large amounts using microbial cell factories in the future.

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Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice

Cited by 28 publications

References 41 publications

Antifungal activity of an allicin derivative against Penicillium expansum via induction of oxidative stress

Antifungal activity of an allicin derivative against Penicillium expansum via induction of oxidative stress

Antioxidant Activities of Natural Polysaccharides and Their Derivatives for Biomedical and Medicinal Applications

New Insights Into the Biosynthesis of Typical Bioactive Components in the Traditional Chinese Medicinal Fungus Cordyceps militaris

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